{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:32:36Z","timestamp":1777789956554,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purposes<\/jats:title>\n                    <jats:p>Obesity is associated with an increased risk of colorectal cancer (CRC), and ghrelin (GHRL) and resistin (RETN) are thought to be related to obesity. Our aim was to investigate whether GHRL and RETN gene variants are associated with CRC risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>All 414 subjects, including 197 cases with CRC and 217 controls, were genotyped for the GHRL (rs26802) and RETN (rs1862513) or -420C&gt;G gene variants using the PCR-RFLP method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings indicated that the RETN -420C&gt;G \u201cCC\u201d genotype, compared with the \u201cGG\u201d and \u201cGC\u201d genotypes, was a marker of decreased CRC susceptibility; the difference remained significant after adjustment for age, BMI, gender, smoking status, NSAID use, and family history of CRC (p=0.020; OR=0.52, 95% CI=0.30-0.90). Furthermore, after adjustment for confounding factors, the -420C&gt;G \u201cCC\u201d genotype, compared with the \u201cGG\u201d genotype, was associated with a decreased risk for CRC (p=0.044; OR=0.53, 95% CI=0.29-0.98). In addition, no significant difference was observed for the GHRL (rs26802) gene variant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To our knowledge, this is the first study suggesting that the RETN -420C&gt;G \u201cCC\u201d genotype is a marker of decreased CRC susceptibility. This observation is relevant from a scientific perspective and deserves further investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/jbm.5000079","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T08:00:00Z","timestamp":1416211200000},"page":"233-238","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Resistin -420C&gt;G Promoter Variant and Colorectal Cancer Risk"],"prefix":"10.1177","volume":"29","author":[{"given":"Touraj","family":"Mahmoudi","sequence":"first","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khatoon","family":"Karimi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maral","family":"Arkani","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Farahani","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Qom University of Medical Sciences, Qom - Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Vahedi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran - Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Dabiri","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Semnan University of Medical Sciences, Semnan - Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Nobakht","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Semnan University of Medical Sciences, Semnan - Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asadollah","family":"Asadi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil - 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