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EML4\u2013 ALK translocations are rare events associated with specific clinicopathological features, such as never or light smoking history, young age and adenocarcinoma with signet ring or acinar histology. Reports suggest ALK gene arrangements are mutually exclusive with EGFR and KRAS mutations. To the best of to our knowledge, this is the first case report of a patient with concurrent KRAS mutation and ALK translocation. This patient had an excellent response to crizotinib, suggesting that the ALK translocation was the oncogenic driver.<\/jats:p>","DOI":"10.5301\/jbm.5000127","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T06:49:31Z","timestamp":1421304571000},"page":"254-257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Lung adenocarcinoma with Concurrent KRAS Mutation and ALK Rearrangement Responding to Crizotinib: Case Report"],"prefix":"10.1177","volume":"30","author":[{"given":"Saul","family":"Campos-Gomez","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, State Oncology Center, ISSEMyM, Toluca - M\u00e9xico"},{"name":"Department of Medical Oncology, National Institute of Medical Science and Nutrition Salvador Zubiran, Distrito Federal - M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Lara-Guerra","sequence":"additional","affiliation":[{"name":"Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas M. 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