{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:34:38Z","timestamp":1777790078788,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2015,4]]},"abstract":"\n Background<\/jats:title>\n Carbohydrate antigen (CA) 19-9 is used as a clinical tumor marker of pancreatic cancer; recent studies report that CA 19-9 is also associated with changes in blood glucose levels. The aim of the present study was to investigate the relationship between serum CA 19-9 levels and early-phase insulin secretion in nondiabetic individuals.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We enrolled 269 normoglycemic participants and 172 prediabetic participants who had undergone the 75-g oral glucose tolerance test during their annual health examination. Insulin secretion was estimated using the disposition index (DI) [(\u0394insulin\n (0-30 min)<\/jats:sub>\n \/\u0394glucose\n (0-30 min)<\/jats:sub>\n \u00d7 (1\/HOMA-IR)], which is an adjusted measure of relationship between \u03b2-cell sensitivity and insulin sensitivity.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Serum CA 19-9 level was significantly higher in the prediabetic participants than in the normoglycemic participants. Simple linear regression analysis showed a negative correlation between CA 19-9 levels and DI for all participants and prediabetic participants (r = -0.126, p = 0.009, and r = -0.189, p = 0.002, respectively). However, in the normoglycemic participants, CA 19-9 levels did not correlate with DI. For all participants, and prediabetic subjects, multivariate linear regression analysis revealed that serum CA 19-9 levels were one of the independent predictors of DI (adjusted \u03b2 = -0.098, p = 0.025, and adjusted \u03b2 = -0.177, p = 0.004, respectively).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Serum CA 19-9 levels significantly correlate with early-phase insulin secretion in the prediabetic individuals. Our results indicate that CA 19-9 may be involved in the endocrine function of pancreas.<\/jats:p>\n <\/jats:sec>","DOI":"10.5301\/jbm.5000130","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T06:49:31Z","timestamp":1421304571000},"page":"169-173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Relation between CA 19-9 level and Early-Phase Insulin Secretion in Normoglycemic and Prediabetic Subjects"],"prefix":"10.1177","volume":"30","author":[{"given":"Masanori","family":"Shimodaira","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Iida Municipal Hospital, Nagano - Japan"},{"name":"Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Niwa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Iida Municipal Hospital, Nagano - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Iida Municipal Hospital, Nagano - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuhiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Iida Municipal Hospital, Nagano - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norinao","family":"Hanyu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Iida Municipal Hospital, Nagano - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo - Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"bibr1-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.10.004"},{"key":"bibr2-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31802dd094"},{"issue":"6","key":"bibr3-jbm.5000130","first-page":"641","volume":"19","author":"Pines E","year":"1995","journal-title":"Gastroenterol Clin Biol"},{"key":"bibr4-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.3.744"},{"key":"bibr5-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181f0e2a0"},{"key":"bibr6-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.25.278"},{"key":"bibr7-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2011.00179.x"},{"issue":"11","key":"bibr8-jbm.5000130","first-page":"4820","volume":"42","author":"Atkinson BF","year":"1982","journal-title":"Cancer Res"},{"key":"bibr9-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.3.302"},{"key":"bibr10-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S011"},{"key":"bibr11-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"bibr12-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2179"},{"key":"bibr13-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2170"},{"key":"bibr14-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"bibr15-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/745189"},{"key":"bibr16-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i40.5357"},{"key":"bibr17-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1177\/172460089601100405"},{"key":"bibr18-jbm.5000130","author":"Kim SH","year":"2013","journal-title":"Endocrine"},{"key":"bibr19-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.2337\/diab.34.10.980"},{"key":"bibr20-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(00)80020-7"},{"key":"bibr21-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602619"},{"key":"bibr22-jbm.5000130","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.007"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/jbm.5000130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/jbm.5000130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/jbm.5000130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:59:06Z","timestamp":1777492746000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/jbm.5000130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.5301\/jbm.5000130"],"URL":"https:\/\/doi.org\/10.5301\/jbm.5000130","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}