{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:35:25Z","timestamp":1777790125958,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The excision repair cross-complementation group 2 (ERCC2) ATP-dependent helicase is an essential member of the DNA repair pathway. It has been observed to be differentially expressed in different cancers, which shows its involvement in carcinogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In the present study we have tried to determine the association of expression patterns of this gene with head and neck carcinogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We first carried out a systematic review of the available studies on the role of ERCC2 in head and neck cancer (HNC). In order to test the hypothesis that the expression patterns of XPD\/ERCC2 play a critical role in HNC pathogenesis, we then conducted a population based case-control study on 81 head and neck tumor samples and adjacent normal-tissue control samples. Reverse transcriptase polymerase chain reaction (RT-PCR) and quantitative polymerase chain reaction (qPCR) were used to assess ERCC2 deregulation at the mRNA level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Expression analysis showed that the ERCC2 expression level was significantly upregulated (p&lt;0.05) in HNC tissues compared with adjacent normal tissues. Furthermore, the expression pattern of ERCC2 was correlated with the expression pattern of Ki-67 and a significant correlation (r = 0.230, p&lt;0.03) was observed between ERCC2 and Ki-67. Spearman's correlation also showed a significant correlation between ERCC2 expression and tumor stage (r = 0.271, p&lt;0.02) and grade (r = 0.228, p&lt;0.02) of HNC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that deregulation of ERCC2 in HNC has the potential to predict a more aggressive cancer phenotype and may be considered a possible biomarker for improved diagnosis and prognosis of HNC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/jbm.5000186","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T04:49:34Z","timestamp":1450068574000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Increased Expression of ERCC2 Gene in Head and Neck Cancer is Associated with Aggressive Tumors: A Systematic Review and Case-Control Study"],"prefix":"10.1177","volume":"31","author":[{"given":"Maryam","family":"Zafeer","sequence":"first","affiliation":[{"name":"Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS Institute of Information Technology, Islamabad - Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishrat","family":"Mahjabeen","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS Institute of Information Technology, Islamabad - Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood Akhtar","family":"Kayani","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Epigenetics Research Group, Department of Biosciences, COMSATS Institute of Information Technology, Islamabad - Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,2,28]]},"reference":[{"key":"bibr1-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29189"},{"issue":"2","key":"bibr2-jbm.5000186","first-page":"49","volume":"11","author":"Moore MA","year":"2010","journal-title":"Asian Pac J Cancer Prev"},{"key":"bibr3-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10143"},{"key":"bibr4-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23848"},{"issue":"1","key":"bibr5-jbm.5000186","first-page":"19","volume":"6","author":"Arora S","year":"2012","journal-title":"Mol Med Rep"},{"key":"bibr6-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00036"},{"issue":"3","key":"bibr7-jbm.5000186","first-page":"783","volume":"29","author":"Akram S","year":"2013","journal-title":"Pak J Med Sci"},{"key":"bibr8-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200511000-00004"},{"key":"bibr9-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2014010130"},{"key":"bibr10-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140700"},{"issue":"3","key":"bibr11-jbm.5000186","first-page":"145","volume":"11","author":"Klement RJ","year":"2014","journal-title":"Cancer Biol Med"},{"key":"bibr12-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.3390\/cancers6031597"},{"key":"bibr13-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.23.10457"},{"key":"bibr14-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040131"},{"key":"bibr15-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1111\/php.12387"},{"key":"bibr16-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1038\/srep04894"},{"key":"bibr17-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S66291"},{"key":"bibr18-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-9-15"},{"key":"bibr19-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.6.2747"},{"key":"bibr20-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1256-3"},{"key":"bibr21-jbm.5000186","author":"Spivak G","journal-title":"DNA Repair (Amst)"},{"key":"bibr22-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12114"},{"key":"bibr23-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-9-15"},{"key":"bibr24-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.10.032"},{"key":"bibr25-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-014-9745-0"},{"key":"bibr26-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2014-6-1-23-34"},{"key":"bibr27-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2012.01.003"},{"key":"bibr28-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1080\/15287390701290725"},{"key":"bibr29-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-011-0253-7"},{"key":"bibr30-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3310-1"},{"key":"bibr31-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0300-2"},{"key":"bibr32-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/ges074"},{"key":"bibr33-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1067"},{"key":"bibr34-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.3.821"},{"key":"bibr35-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-4-9"},{"issue":"1","key":"bibr36-jbm.5000186","first-page":"25","volume":"29","author":"De Petrini M","year":"2006","journal-title":"New Microbiol"},{"key":"bibr37-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.12.2219"},{"key":"bibr38-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.9.1084"},{"key":"bibr39-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.01.015"},{"key":"bibr40-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0162"},{"key":"bibr41-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2005.06.002"},{"key":"bibr42-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.08.010"},{"key":"bibr43-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi280"},{"issue":"6","key":"bibr44-jbm.5000186","first-page":"294","volume":"50","author":"Bau DT","year":"2007","journal-title":"Chin J Physiol"},{"key":"bibr45-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1911"},{"key":"bibr46-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2006.0537"},{"key":"bibr47-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22547"},{"key":"bibr48-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0252"},{"key":"bibr49-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1080\/15287390801988160"},{"key":"bibr50-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-104"},{"key":"bibr51-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24442"},{"key":"bibr52-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1007\/BF03208865"},{"key":"bibr53-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.1.42"},{"key":"bibr54-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.08.009"},{"key":"bibr55-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.03.004"},{"key":"bibr56-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0224-x"},{"key":"bibr57-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.09.001"},{"key":"bibr58-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.476"},{"key":"bibr59-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-1993-8"},{"key":"bibr60-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.02.043"},{"key":"bibr61-jbm.5000186","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10231"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/jbm.5000186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/jbm.5000186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/jbm.5000186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:59:17Z","timestamp":1777492757000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/jbm.5000186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.5301\/jbm.5000186"],"URL":"https:\/\/doi.org\/10.5301\/jbm.5000186","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}