{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:17:41Z","timestamp":1789438661706,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>When advanced, oral squamous cell carcinoma (OSCC) may involve adjacent non-epithelial structures, and the prognosis is worse for bone invasion. Human relaxin-2 is a peptide hormone that has recently been associated with cancer. It can induce human osteoclast differentiation and activation, suggesting a role in tumor-driven osteolysis. This study was a preliminary assessment of the prognostic role of relaxin-2 in surgical specimens of OSCC tissue and adjacent but uninvolved mandibular\/maxillary bone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relaxin-2 immunohistochemical expression and reaction intensity were assessed in tumor and uninvolved adjacent mandibular\/maxillary bone specimens from 23 operated OSCC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All OSCC specimens were positive for relaxin-2. The intensity of its reaction in OSCC correlated significantly with the pattern of the tumor's invasion front (p = 0.02), being higher with the infiltrative pattern. Mean relaxin-2 immunohistochemical expression was higher in patients whose OSCC recurred after treatment than those experiencing no recurrence (81.3% \u00b1 22.6% vs. 59.5% \u00b1 29.7%, respectively). A significant direct association emerged between relaxin-2 expression in OSCC specimens and recurrence rate (p = 0.049).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Relaxin-2 expression in OSCC should be further investigated as a potentially useful marker for identifying patients at higher risk of recurrence, who might benefit from closer follow-up and more aggressive adjuvant therapy. In other oncological settings, increasing evidence of relaxin being produced by cancer cells is prompting efforts to synthesize human relaxin-2 analogs capable of acting as antagonists and limiting tumor growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/jbm.5000219","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T17:39:32Z","timestamp":1466876372000},"page":"324-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Relaxin-2 Expression in Oral Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"31","author":[{"given":"Gino","family":"Marioni","sequence":"first","affiliation":[{"name":"Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Ottaviano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Cappellesso","sequence":"additional","affiliation":[{"name":"Department of Medicine DIMED, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Maxillofacial Surgery Unit, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Marchese-Ragona","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Stritoni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Maxillofacial Surgery Unit, Padua University, Padua - Italy"},{"name":"Maxillofacial Surgery Unit, Treviso Hospital, Treviso - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Zanoletti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Favaretto","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Valentini","sequence":"additional","affiliation":[{"name":"Department of Medicine DIMED, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Apolloni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Maxillofacial Surgery Unit, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Department of Medicine DIMED, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Blandamura","sequence":"additional","affiliation":[{"name":"Department of Medicine DIMED, Padua University, Padua - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,30]]},"reference":[{"issue":"2","key":"bibr1-jbm.5000219","first-page":"87","volume":"65","author":"Torre LA","year":"2015","journal-title":"Global cancer statistics, 2012. 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