{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:36:24Z","timestamp":1778769384549,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Malignant pleural mesothelioma (MPM) is a relatively rare tumor, with the epithelioid type occurring more frequently. Several biomarkers have been suggested for screening and early diagnosis of MPM. Currently, high levels of soluble mesothelin-related peptides (SMRP), plasma osteopontin (pOPN) and vimentin have been reported in patients with MPM as promising markers for diagnosis, but their clinical use in monitoring is still discussed. The aim of our study was to evaluate the usefulness of these substances as markers of the clinical response to treatment in patients suffering from epithelioid mesothelioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>219 serum samples from 56 patients were collected during follow-up and the clinical response to therapy was recorded. Percentage differences between 2 consecutive measurements of SMRP, osteopontin and vimentin (\u0394 markers) by means of commercially available kits were correlated with changes in the clinical course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\u0394 SMRP, \u0394 pOPN and \u0394 vimentin showed statistically significant differences between the disease categories stable disease, partial response and disease progression (p = 0.0001, p = 0.035 and p = 0.0025 for SMRP, pOPN and vimentin, respectively). Moreover, contingency table analysis showed statistically significant differences between clinical response and \u0394 of each marker clustered into 3 groups (&lt;-20%, between -20% and +20%, &gt;+20%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The time course of \u0394 SMRP and \u0394 vimentin was strongly associated with disease status, and so was the time course of pOPN, albeit to a lesser extent. These markers appear to be particularly effective in cases of partial response and disease progression, while their possible use in stable disease should be better investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/jbm.5000229","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T08:49:49Z","timestamp":1474361389000},"page":"126-131","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Serum Mesothelin, Osteopontin and Vimentin: Useful Markers for Clinical Monitoring of Malignant Pleural Mesothelioma"],"prefix":"10.1177","volume":"32","author":[{"given":"Alessandra","family":"Bonotti","sequence":"first","affiliation":[{"name":"Occupational and Preventive Medicine Unit, University Hospital of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Simonini","sequence":"additional","affiliation":[{"name":"Occupational and Preventive Medicine Unit, University Hospital of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Pantani","sequence":"additional","affiliation":[{"name":"Occupational and Preventive Medicine Unit, University Hospital of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Giusti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Donadio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosa","family":"Mazzoni","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Chella","sequence":"additional","affiliation":[{"name":"Pulmonary Unit, University Hospital of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Marconi","sequence":"additional","affiliation":[{"name":"Pulmonary Unit, University Hospital of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolino","family":"Ambrosino","sequence":"additional","affiliation":[{"name":"Auxilium Vitae, Volterra, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Lucchi","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department, University of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Mussi","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department, University of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Cristaudo","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudy","family":"Foddis","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"bibr1-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj912"},{"key":"bibr2-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690105"},{"key":"bibr3-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00000811"},{"key":"bibr4-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70149-8"},{"issue":"1","key":"bibr5-jbm.5000229","first-page":"181","volume":"52","author":"Chang K.","year":"1992","journal-title":"Cancer Res"},{"key":"bibr6-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14794-0"},{"key":"bibr7-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.03.020"},{"issue":"1","key":"bibr8-jbm.5000229","first-page":"87","volume":"63","author":"Grigoriu B.D.","year":"2008","journal-title":"Thorax"},{"key":"bibr9-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200511-1789OC"},{"key":"bibr10-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0629"},{"key":"bibr11-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.9944"},{"key":"bibr12-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182272294"},{"key":"bibr13-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201300052"},{"key":"bibr14-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.4.1122"},{"key":"bibr15-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh059"},{"key":"bibr16-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.079327"},{"key":"bibr17-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1477"},{"key":"bibr18-jbm.5000229","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1125OC"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/jbm.5000229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/jbm.5000229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/jbm.5000229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:59:28Z","timestamp":1777492768000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/jbm.5000229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.5301\/jbm.5000229"],"URL":"https:\/\/doi.org\/10.5301\/jbm.5000229","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}