{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:50:24Z","timestamp":1791582624587,"version":"4.3.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Preferred hemodialysis (HD) access is an autologous fistula. Vascular grafts are used in patients with vessels unsuitable to accomplish an arteriovenous fistula (AVF). It is recommended that most current grafts mature in situ for 2\u20133 weeks before being accessed. Graft complications occur because the structure was not designed for the trauma of repeated cannulation. This study graft has a different structure that enables early use. Its design minimizes weeping through the graft walls and is meant to endure repeated access, thus minimizing the use of HD catheters. The purpose of this study was to show that the Flixene\u2122 graft can be safely placed in patients where fistulas have failed and can be cannulated in 24\u201372 hr, while maintaining patency rates similar to other polytetrafluoroethylene (PTFE) grafts on the market. Flixene\u2122 configuration should also reduce the incidence of pseudoaneurysms and seromas. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> A prospective two-center study placed 33 grafts in 33 patients; graft efficacy, post-operative complications, and patency were evaluated. Ease of cannulation and dialysis center complications related to early cannulation were documented. Six month follow-up data was analyzed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Successful access was achieved in all 33 patients within 72 hr (29 patients within 24 hr). Overall primary patency at 6 months was 49%; primary-assisted patency at 6 months was 80%. No pseudoaneurysms or seromas were documented at 6 months. Complications were typical of graft access. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Early cannulation was successful in all patients. Primary and secondary patency rates at 6\u2013months were equivalent to other data reported on PTFE grafts. Flixene\u2122 successfully prevented pseudoaneurysm and seroma formation at 6 months of prospective follow-up. This graft is a better last-resort option for patients who cannot receive a fistula, compared to double-lumen cuffed catheters. <\/jats:p><\/jats:sec>","DOI":"10.5301\/jva.2011.6351","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T12:29:32Z","timestamp":1297340972000},"page":"248-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Early Cannulation Prosthetic Graft (Flixene\u2122) for Arteriovenous Access"],"prefix":"10.1177","volume":"12","author":[{"given":"A. Frederick","family":"Schild","sequence":"first","affiliation":[{"name":"Florida International University Herbert Wertheim College of Medicine, Miami, FL - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl S.","family":"Schuman","sequence":"additional","affiliation":[{"name":"Oregon Surgical Consultants, Portland, OR - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlene","family":"Noicely","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Kaufman","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Gillaspie","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fuller","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Collier","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Ronfeld","sequence":"additional","affiliation":[{"name":"Oregon Surgical Consultants, Portland, OR - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Ravikumaran","family":"Nair","sequence":"additional","affiliation":[{"name":"Florida International University Herbert Wertheim College of Medicine, Miami, FL - USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,9,16]]},"reference":[{"key":"bibr1-JVA.2011.6351","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.04.029"},{"key":"bibr2-JVA.2011.6351","unstructured":"Fistula First National Vascular Access Improvement Initiative. Change package: vascular access for hemodialysis - increasing the incidence and prevalence of AV fistulas. Available at: http:\/\/www.fistulafirst.org\/%5Cconceptlg.htm. 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