{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:53:03Z","timestamp":1778932383793,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T00:00:00Z","timestamp":1436486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Purpose<\/jats:title> A lengthy healing and maturation period follows standard surgical preparation of a permanent arteriovenous access, often requiring or extending use of a venous catheter (VC) for hemodialysis. The InterGraft\u2122 Anastomotic Connector System was developed for minimally invasive anastomosis of an arteriovenous graft (AVG). The venous and arterial InterGraft\u2122 connectors are designed to provide optimized flow dynamics and may result in reduction of AVG stenosis. This pilot study evaluated placement procedure success, patency and safety of the InterGraft\u2122 connectors. <\/jats:p><\/jats:sec>Methods<\/jats:title> Nine AVGs were implanted in nine patients currently receiving dialysis with a VC. The study allowed use of both connectors (n = 5) or use of the venous connector with a sutured arterial anastomosis (n = 4). Monthly ultrasound examinations were performed throughout the six-month follow-up. AVG angiography was performed at five months. Endpoints included procedure success (acceptable graft flow at end of procedure, without significant bleeding or need for emergent surgery), patency, and device-related major adverse events. <\/jats:p><\/jats:sec>Results<\/jats:title> Procedure success was attained in all patients. AVGs were used for dialysis within 17 days, on average, and VCs were removed. Three patients exited the study early for reasons unrelated to the InterGraft\u2122 connectors. The remaining six patients had patent grafts: two with assisted and four with unassisted patency. AVG flow rates were greater than 1 L\/minute. No dilatations or aneurysms were observed by angiography. There were no device-related major adverse events. <\/jats:p><\/jats:sec>Conclusions<\/jats:title> The InterGraft\u2122 connectors can be safely and successfully used for AVG anastomoses, with acceptable near-term patency. Further clinical evaluation is warranted. <\/jats:p><\/jats:sec>","DOI":"10.5301\/jva.5000481","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T10:44:57Z","timestamp":1444387497000},"page":"111-117","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcatheter Anastomosis Connector System for Vascular access Graft Placement: Results from a First-in-human Pilot Study"],"prefix":"10.1177","volume":"17","author":[{"given":"Adrian","family":"Ebner","sequence":"first","affiliation":[{"name":"Italian Hospital, Asuncion - Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Ross","sequence":"additional","affiliation":[{"name":"Regional Medical Center, Orangeburg, South Carolina - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy M.","family":"Setum","sequence":"additional","affiliation":[{"name":"Phraxis, Inc., Saint Paul, Minnesota - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Kallok","sequence":"additional","affiliation":[{"name":"Phraxis, Inc., Saint Paul, Minnesota - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander S.","family":"Yevzlin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Wisconsin, Madison, Wisconsin - USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,10]]},"reference":[{"key":"bibr1-jva.5000481","unstructured":"National Kidney Foundation. 2006 Updates Clinical Practice Guidelines and Recommendations. Clinical practice guidelines for vascular access. Guideline 2 - Selection and Placement of Hemodialysis Access. Available at: https:\/\/www.kidney.org\/sites\/default\/files\/docs\/12-50-0210_jag_dcp_guidelines-va_oct06_sectionc_ofc.pdf. Accessed September 29, 2015."},{"key":"bibr2-jva.5000481","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32834b33c4"},{"key":"bibr3-jva.5000481","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.18.2164"},{"key":"bibr4-jva.5000481","doi-asserted-by":"publisher","DOI":"10.1177\/112972980901000301"},{"key":"bibr5-jva.5000481","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2010.07.004"}],"container-title":["The Journal of Vascular Access"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/jva.5000481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/jva.5000481","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/jva.5000481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T17:12:52Z","timestamp":1740762772000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/jva.5000481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,10]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.5301\/jva.5000481"],"URL":"https:\/\/doi.org\/10.5301\/jva.5000481","relation":{},"ISSN":["1129-7298","1724-6032"],"issn-type":[{"value":"1129-7298","type":"print"},{"value":"1724-6032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,10]]}}}