{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:31:55Z","timestamp":1740893515119,"version":"3.38.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p> The aim of the study is to evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) treatment in patients with local prostate cancer recurrence after radiotherapy. <\/jats:p><jats:p> From February 2009 to June 2010, 14 patients with prostate cancer recurrence after radiotherapy were selected for HIFU treatment; all patients had a positive TRUS-guided biopsy and the absence of distant metastases was confirmed by computer tomography, PET choline or bone scintigraphy We classified all patients in 3 groups using D'Amico's classification: 4 patients high risk (PSA &gt; 20 ng\/ml - 8 \u2264 Gleason Score \u226410 \u2013 clinical stage \u2265T2c), 8 patients intermediate risk (10 &lt; PSA \u226420 ng\/ml - Gleason Score=7 \u2013 clinical stage=T2b), and 2 patients low risk (PSA \u226410 ng\/ml - Gleason Score\u22646 \u2013 clinical stage=T1c-T2a). Progression was defined using Stuttgart definition (PSA&gt;PSAnadir+1.2ng\/ml) or after adjuvant therapy introduction. All complications were recorded. Of the 14 patients selected, 12 patients underwent HIFU treatments; 2 patients were excluded because of rectal strictures induced by radiotherapy. At a mean 13 months\u2019 follow-up, biochemical success rate was obtained in 1 of the high risk patients and in 5 of the low and intermediate risk patients; 1 man died for a disease not correlated with prostate cancer recurrence. Complications included urinary tract infection, acute urinary retentions, urethral strictures and light stress incontinence. <\/jats:p><jats:p> In our experience salvage HIFU is a safe treatment option for local relapse after radiotherapy; its efficacy depends on a careful patient selection. <\/jats:p>","DOI":"10.5301\/ru.2011.8523","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T15:06:20Z","timestamp":1311087980000},"page":"180-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["High-Intensity Focused Ultrasound (HIFU): Our Experience in the Treatment of Prostate Cancer Relapsing after Radiotherapy"],"prefix":"10.1177","volume":"78","author":[{"given":"Luca","family":"Giovanessi","sequence":"first","affiliation":[{"name":"Cattedra e Divisione di Urologia, Spedali Civili di Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Peroni","sequence":"additional","affiliation":[{"name":"Cattedra e Divisione di Urologia, Spedali Civili di Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Mirabella","sequence":"additional","affiliation":[{"name":"Cattedra e Divisione di Urologia, Spedali Civili di Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Vismara","family":"Fugini","sequence":"additional","affiliation":[{"name":"Cattedra e Divisione di Urologia, Spedali Civili di Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Zani","sequence":"additional","affiliation":[{"name":"Cattedra e Divisione di Urologia, Spedali Civili di Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Cosciani","family":"Cunico","sequence":"additional","affiliation":[{"name":"Cattedra e Divisione di Urologia, Spedali Civili di Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Simeone","sequence":"additional","affiliation":[{"name":"Cattedra e Divisione di Urologia, Spedali Civili di Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,7,19]]},"reference":[{"key":"bibr1-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi098"},{"key":"bibr2-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00637-4"},{"key":"bibr3-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02977-2"},{"key":"bibr4-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200109000-00017"},{"key":"bibr5-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90945-0"},{"key":"bibr6-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.1.230"},{"key":"bibr7-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.137"},{"key":"bibr8-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00784-2"},{"key":"bibr9-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.01.002"},{"key":"bibr10-RU.2011.8523","first-page":"1","volume":"108","author":"Chavrier F.","year":"2000","journal-title":"Jaloust JOL AM"},{"key":"bibr11-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08518.x"},{"key":"bibr12-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08355.x"},{"key":"bibr13-RU.2011.8523","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.04.091"}],"container-title":["Urologia Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/RU.2011.8523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/RU.2011.8523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T08:11:27Z","timestamp":1740816687000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/RU.2011.8523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.5301\/RU.2011.8523"],"URL":"https:\/\/doi.org\/10.5301\/ru.2011.8523","relation":{},"ISSN":["0391-5603","1724-6075"],"issn-type":[{"type":"print","value":"0391-5603"},{"type":"electronic","value":"1724-6075"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}