{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:07:11Z","timestamp":1780106831378,"version":"3.54.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Aims and Background<\/jats:title><jats:p> In this retrospective analysis, we evaluated the use of stereotactic body radiation therapy in the management of adrenal metastases from non-small cell lung cancer and report our single center experience. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Study design<\/jats:title><jats:p> Fifteen non-small cell lung cancer patients (9 male, 6 female) with 17 adrenal metastases referred to Gulhane Military Medical Academy Radiation Oncology Department were treated using active breathing control-guided stereotactic body radiation therapy between December 2009 and October 2013. Dose per fraction was 10 Gy to deliver a total dose of 30 Gy over 3 consecutive days for all metastatic adrenal lesions. The mean gross tumor volume was 28.4 cc (range 6.6-101.5) and mean planning target volume was 57.4 cc (range 16.5-143.8). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> At a median follow-up of 16 months, local control was 86.7% and overall survival was 33.3%. Median disease-free survival was 10 months. Treatment response according to RECIST was categorized as complete response in 3 patients (20%), partial response in 5 patients (33.3%), stable disease in 5 patients (33.3%), and progressive disease in 2 patients (13.3%). Most common acute toxicity was grade 1 nausea (n = 7) and grade 1 fatigue (n = 12). There was no case of grade \u22653 acute or late toxicity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Stereotactic body radiation therapy offers a safe and efficacious management strategy for adrenal metastases from non-small cell lung cancer by providing excellent local control with negligible treatment related toxicity. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000222","type":"journal-article","created":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T10:50:43Z","timestamp":1424688643000},"page":"98-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Evaluation of Stereotactic Body Radiation Therapy in the Management of Adrenal Metastases from Non-Small Cell Lung Cancer"],"prefix":"10.1177","volume":"101","author":[{"given":"Hakan","family":"Gamsiz","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Gulhane Military Medical Academy, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Beyzadeoglu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gulhane Military Medical Academy, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Sager","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gulhane Military Medical Academy, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcuk","family":"Demiral","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gulhane Military Medical Academy, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferrat","family":"Dincoglan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gulhane Military Medical Academy, Ankara - 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