{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:47:39Z","timestamp":1738043259774,"version":"3.33.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Aims and Background<\/jats:title><jats:p> The aim of this report was to describe the way in which a rare and niche disease like ampulla of Vater carcinoma (AVC) was treated in real-world clinical practice. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Study Design<\/jats:title><jats:p> A retrospective analysis of consecutive patients with a diagnosis of AVC treated at our medical oncology unit between August 2004 and August 2013 was performed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> We evaluated 8 consecutive patients with a median age of 60 years (range 56\u201384). At the last follow-up, 4 patients were alive without evidence of disease and 4 patients had died. The median follow-up time was 21.51 months (range 1\u2013100.43), the median overall survival 23.19 months (range 7.07\u2013102.2), and the median disease-free survival 18.26 months (range 0\u2013102.2). Six patients underwent surgery, which consisted of pylorus-preserving pancreaticoduodenectomy, R0 in all cases. Tumor histology was adenocarcinoma in all patients. Two patients presented with locally advanced disease. Only 1 patient presented with metastases while 3 patients subsequently developed metastases. Two patients received chemotherapy for metastatic disease; in both cases disease progression was observed at the first disease evaluation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> We can consider AVC as a pathology niche and pancreaticoduodenectomy as the effective treatment for these patients. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000267","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T11:49:41Z","timestamp":1429876181000},"page":"e75-e78","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ampulla of Vater Carcinoma in Real-World Clinical Practice: A Case Series"],"prefix":"10.1177","volume":"101","author":[{"given":"Jacopo","family":"Giuliani","sequence":"first","affiliation":[{"name":"Department of Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (Verona) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Piacentini","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (Verona) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bonetti","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mater Salutis Hospital, ASL 21 della Regione Veneto, Legnago (Verona) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"bibr1-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2007.9016"},{"key":"bibr2-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21374"},{"key":"bibr3-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.01.030"},{"key":"bibr4-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21390"},{"key":"bibr5-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0099-4"},{"key":"bibr6-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-1995-8"},{"key":"bibr7-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.12.003"},{"key":"bibr8-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090316"},{"key":"bibr9-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1414.024"},{"key":"bibr10-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/719459"},{"key":"bibr11-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-005-1067-z"},{"issue":"5","key":"bibr12-tj.5000267","first-page":"645","volume":"105","author":"Sharp K.W.","year":"1989","journal-title":"Surgery."},{"key":"bibr13-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-007-1279-5"},{"key":"bibr14-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.7352"},{"volume-title":"Surveillance, Epidemiology, and End Results (SEER) Survival Monograph: Cancer survival among adults\u2014US SEER program, 1988\u20132001.","year":"2007","author":"Key C.","key":"bibr15-tj.5000267"},{"volume-title":"Surveillance, Epidemiology, and End Results (SEER) Survival Monograph: Cancer survival among adults\u2014US SEER program, 1988\u20132001.","year":"2007","author":"Key C.","key":"bibr16-tj.5000267"},{"key":"bibr17-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh351"},{"key":"bibr18-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.7145"},{"key":"bibr19-tj.5000267","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70301-1"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/tj.5000267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T21:30:50Z","timestamp":1738013450000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/tj.5000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.5301\/tj.5000267"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000267","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"type":"print","value":"0300-8916"},{"type":"electronic","value":"2038-2529"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}