{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:05:55Z","timestamp":1775019955150,"version":"3.50.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Pulmonary toxicity is a well-known complication observed with several anticancer drugs. Docetaxel, a taxane chemotherapy drug widely used in the treatment of many types of solid tumors including non-small cell lung cancer (NSCLC), rarely causes infiltrative pneumonitis. The exact mechanism by which docetaxel develops this side effect is not well understood; probably it is produced by type I and IV hypersensitivity responses. Here we describe 2 cases of infiltrative pneumonitis induced by docetaxel as second-line chemotherapy in advanced NSCLC. <\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p> Two patients with advanced NSCLC were treated with weekly docetaxel as second-line chemotherapy. After 3 courses of chemotherapy, restaging computed tomography (CT) of the chest revealed bilateral diffuse ground-glass opacities with a peribronchial distribution possibly indicative of hypersensitivity pneumonitis. No evidence of pulmonary embolus or pleural effusion was found. Fiberoptic bronchoscopy showed normal bronchi without lymphangitis; biopsies showed interstitial fibrosis without tumor cells. Bronchial tissue laboratory tests for fungi or bacilli were negative. No malignant cells were found at bronchoalveolar lavage. The patients were given high-dose corticosteroid therapy with prednisone 0.7 mg per kilogram per day. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> After 1 month of therapy, contrast-enhanced chest CT showed complete disappearance of the pulmonary changes in both patients. Spirometry and blood gas analysis revealed complete recovery of pulmonary function. The patients continued their oncological follow-up program. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Pulmonary injury is a rare adverse event during docetaxel chemotherapy. Prompt treatment with high-dose corticosteroids is needed to avoid worsening of respiratory performance. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000275","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T11:49:41Z","timestamp":1429876181000},"page":"e92-e95","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["A Commentary on Interstitial Pneumonitis Induced by Docetaxel: Clinical Cases and Systematic Review of the Literature"],"prefix":"10.1177","volume":"101","author":[{"given":"Giovenzio","family":"Genestreti","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology, AUSL Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Di Battista","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, AUSL Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Trisolini","sequence":"additional","affiliation":[{"name":"Department of Pneumology, AUSL Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Denicol\u00f2","sequence":"additional","affiliation":[{"name":"Department of Radiology, AUSL Rimini, Cervesi Hospital, Cattolica, Rimini - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirca","family":"Valli","sequence":"additional","affiliation":[{"name":"Department of Pathology, AUSL Rimini, Infermi Hospital, Rimini - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi Arcangelo","family":"Lazzari-Agli","sequence":"additional","affiliation":[{"name":"Department of Pneumology, AUSL Rimini, Ceccarini Hospital, Riccione - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Dal Piaz","sequence":"additional","affiliation":[{"name":"Department of Radiology, AUSL Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"De Biase","sequence":"additional","affiliation":[{"name":"Department of Medicine, Anatomic Pathology Unit, AUSL Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bartolotti","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, AUSL Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, AUSL Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba A.","family":"Brandes","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, AUSL Bologna, Bologna - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"bibr1-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.5.1649"},{"key":"bibr2-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008226416896"},{"issue":"2","key":"bibr3-tj.5000275","first-page":"199","volume":"15","author":"Etienne B.","year":"1998","journal-title":"Rev Mal Respir."},{"key":"bibr4-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.2071"},{"key":"bibr5-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10263"},{"key":"bibr6-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-007-0106-4"},{"key":"bibr7-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1159\/000200015"},{"issue":"1","key":"bibr8-tj.5000275","first-page":"103","volume":"39","author":"Komaki C.","year":"2012","journal-title":"Gan To Kagaku Ryoho."},{"issue":"3","key":"bibr9-tj.5000275","first-page":"1103","volume":"32","author":"Tamiya A.","year":"2012","journal-title":"Anticancer Res."},{"key":"bibr10-tj.5000275","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2012.53.5.371"},{"key":"bibr11-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1177\/1078155211429384"},{"key":"bibr12-tj.5000275","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.750734"},{"key":"bibr13-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-010-0058-4"},{"key":"bibr14-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.4.1031"},{"key":"bibr15-tj.5000275","doi-asserted-by":"publisher","DOI":"10.1177\/030089161309900325"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/tj.5000275","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T18:43:50Z","timestamp":1741113830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/tj.5000275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.5301\/tj.5000275"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000275","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}