{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:54:40Z","timestamp":1773899680662,"version":"3.50.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Aims and Background<\/jats:title><jats:p> The time of lung cancer screening may provide the ideal setting to discuss and initiate a smoking cessation plan that includes pharmacologic aids. No studies to date have fully investigated the potential effectiveness of such combined approach. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We prospectively evaluated the biochemically verified 1-year continuous abstinence rate from smoking of 187 persistent smokers enrolled within the Multicentric Italian Lung Detection Trial (MILD), who received a pharmacologic aid to quit smoking with varenicline along with behavioral counseling. The propensity of study subjects to succeed in smoking cessation was also monitored. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> At 12 months, the continuous abstinence rate from smoking was achieved in 37 out of 187 patients (19.8%), with a propensity to succeed in smoking cessation for the assisted attempt equal to 1.43, as compared to an unassisted MILD patient. At the end of the third month of therapy, 48.7% of subjects showed a continuous abstinence rate, while only 33.7% of patients were abstinent from smoking at 6 months. At baseline, the subgroup of MILD participants who were originally allocated to lung tomography showed higher smoking intensity than those allocated to no screening. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> A combined smoking cessation intervention can be implemented with satisfactory results within a lung cancer screening program; this preliminary observation needs to be replicated in a prospective investigation. Clinicians should consider that lung cancer screening may be falsely reassuring for persistent smokers; therefore it should always be coupled with a smoking cessation program. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000282","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T15:06:39Z","timestamp":1428073599000},"page":"306-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["A Combined Smoking Cessation Intervention within a Lung Cancer Screening Trial: A Pilot Observational Study"],"prefix":"10.1177","volume":"101","author":[{"given":"Paolo","family":"Pozzi","sequence":"first","affiliation":[{"name":"Tobacco Control Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Munarini","sequence":"additional","affiliation":[{"name":"Tobacco Control Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bravi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy"},{"name":"Department of Clinical Sciences and Community Health, University of Milan, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy"},{"name":"Department of Clinical Sciences and Community Health, University of Milan, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Boffi","sequence":"additional","affiliation":[{"name":"Tobacco Control Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugo","family":"Pastorino","sequence":"additional","affiliation":[{"name":"Unit of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"bibr1-tj.5000282","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"bibr2-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)06093-6"},{"key":"bibr3-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"bibr4-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2001.0935"},{"key":"bibr5-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11813"},{"key":"bibr6-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21045"},{"key":"bibr7-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.102475"},{"key":"bibr8-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.133751"},{"issue":"44","key":"bibr9-tj.5000282","first-page":"1513","volume":"60","author":"Centers for Disease Control and Prevention (CDC)","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"bibr10-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31822e59b3"},{"key":"bibr11-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5521"},{"key":"bibr12-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00035410"},{"key":"bibr13-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.10.011"},{"key":"bibr14-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2008.04.009"},{"key":"bibr15-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.1.47"},{"key":"bibr16-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.1.56"},{"key":"bibr17-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328351e1b6"},{"key":"bibr18-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"bibr19-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"bibr20-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.281.6238.484"},{"key":"bibr21-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.3.758"},{"key":"bibr22-tj.5000282","first-page":"3551","volume-title":"Encyclopedia of Biostatistics","volume":"5","author":"Rosenbaum P.R.","year":"1998"},{"key":"bibr23-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.20079"},{"key":"bibr24-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2004.00995.x"},{"key":"bibr25-tj.5000282","first-page":"CD009329","volume":"5","author":"Cahill K.","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"bibr26-tj.5000282","first-page":"CD009670","volume":"12","author":"Stead L.F.","year":"2012","journal-title":"Cochrane Database Syst Rev."},{"key":"bibr27-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02646.x"},{"key":"bibr28-tj.5000282","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100048108"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/tj.5000282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T14:08:49Z","timestamp":1738073329000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/tj.5000282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,4]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.5301\/tj.5000282"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000282","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,4]]}}}