{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:44:33Z","timestamp":1738043073951,"version":"3.33.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Aims and Background<\/jats:title><jats:p> To compare 2 multifraction radiotherapy schedules in the palliation of painful bone metastases. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Study Design<\/jats:title><jats:p> We retrospectively analyzed clinical data of 105 patients with a total of 140 painful bone metastases who were treated with 20 Gy in 5 fractions or 30 Gy in 10 fractions. The primary tumors were breast (30%), lung (28%), and prostate (14%). The main sites of irradiation were spine (n = 79) and sacrum or pelvis (n = 39). Pain was graded by patients according to the pain numeric rating scale just before and 1 month after radiotherapy. Pain progression was defined as an increase \u22652 on pain scale after an initial response. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The overall response rate at 1 month was 88.6%. Overall response rate was 89.6% in the 20-Gy arm and 87.3% in the 30-Gy arm (p = 0.669). The rate of complete response was statistically better in patients treated with 30 Gy (p = 0.019). The mean reduction in pain was 3.2 in the 20-Gy group and 3.6 in the 30-Gy group. Pain progression was 6.5% and 1.6%, respectively. The incidence of acute toxicity was statistically significantly higher in the 30-Gy arm (23.8%) than in the 20-Gy arm (2.6%) (p = 0.001). One pathologic fracture of the irradiated bone was observed in the 30-Gy arm. Two lesions, one in each group, were re-irradiated for pain recurrence. Pain progression was found in 6.5% of the irradiated lesions in the 20-Gy arm and in 1.6% in the 30-Gy arm. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> In our series, both regimens achieved high rate of pain relief, although the group treated with higher total dose reported better complete response rate. The 30-Gy arm had a significantly higher rate of acute toxicity. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000286","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T11:49:41Z","timestamp":1429876181000},"page":"318-322","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Multifraction Radiotherapy for Palliation of Painful Bone Metastases: 20 Gy versus 30 Gy"],"prefix":"10.1177","volume":"101","author":[{"given":"Maurizio","family":"Valeriani","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Sant'Andrea Hospital, University \u201cSapienza\u201d, Rome - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Scaringi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sant'Andrea Hospital, University \u201cSapienza\u201d, Rome - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Blasi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Sant'Andrea Hospital, University \u201cSapienza\u201d, Rome - 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