{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:02:35Z","timestamp":1761102155362,"version":"3.38.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> The aim of this study was to compare the T lymphocyte subsets of chronic myelogenous leukemia (CML) patients who had a complete cytogenetic response (CCyR) after treatment with imatinib (IM) or homoharringtonine (HHT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> T and Th lymphocyte subsets in CCyR patients treated with HHT (n = 15) or IM (n = 16) were assayed with flow cytometry. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> It was found that there were no differences in T lymphocyte subset proportions at the time of achieving CCyR<jats:sub>0<\/jats:sub> and also no difference in the CD8<jats:sup>+<\/jats:sup>T cell proportions at the 12<jats:sup>th<\/jats:sup> month after CCyR (CCyR<jats:sub>12<\/jats:sub>), between the 2 groups. The values of CD3<jats:sup>+<\/jats:sup>T, CD4<jats:sup>+<\/jats:sup>T, CD8<jats:sup>+<\/jats:sup>T, CD4<jats:sup>+<\/jats:sup>T\/CD8<jats:sup>+<\/jats:sup>T, Th1 and Th2 cells were 54.21% \u00b1 6.12% vs. 44.32% \u00b1 4.85%, 29.83% \u00b1 5.53% vs. 22.27% \u00b1 3.22%, 24.66 \u00b1 4.91 vs. 25.41% \u00b1 5.72%, 1.11 \u00b1 0.23 vs. 0.92 \u00b1 0.19, 10.23% \u00b1 4.24% vs. 8.34% \u00b1 3.45% and 11.12% \u00b1 3.91% vs. 13.67% \u00b1 4.78%, respectively in the HHT group and IM group at CCyR<jats:sub>12<\/jats:sub>, which meant that the proportions of CD3<jats:sup>+<\/jats:sup>T, CD4<jats:sup>+<\/jats:sup>T and Th1 cells and the ratio of CD4<jats:sup>+<\/jats:sup>T to CD8<jats:sup>+<\/jats:sup>T cells were higher and the CD8<jats:sup>+<\/jats:sup>T and Th2 cell proportions were lower in the HHT group than in the IM group. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> HHT has a weaker immunodepression effect on T lymphocyte subsets compared with IM. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000287","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T10:19:11Z","timestamp":1433499551000},"page":"323-327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunological Status of Chronic Myelogenous Leukemia Patients with Complete Cytogenetic Response after Treatment"],"prefix":"10.1177","volume":"101","author":[{"given":"Zhikui","family":"Deng","sequence":"first","affiliation":[{"name":"Hematology Department, Huai'an First People's Hospital, Nanjing Medical University, Huaian, Jiangsu - PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Hematology Department, Huai'an First People's Hospital, Nanjing Medical University, Huaian, Jiangsu - PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-feng","family":"Li","sequence":"additional","affiliation":[{"name":"Hematology Department, Huai'an First People's Hospital, Nanjing Medical University, Huaian, Jiangsu - PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"bibr1-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.319"},{"key":"bibr2-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.10.3074"},{"key":"bibr3-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1007\/BF03006921"},{"issue":"3","key":"bibr4-tj.5000287","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/cncr.25438","volume":"117","author":"Cortes J.","year":"2011","journal-title":"Cancer."},{"key":"bibr5-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2009.2179"},{"key":"bibr6-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2303"},{"key":"bibr7-tj.5000287","doi-asserted-by":"publisher","DOI":"10.2174\/157488810791824485"},{"key":"bibr8-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0302"},{"key":"bibr9-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403933"},{"issue":"12","key":"bibr10-tj.5000287","first-page":"1413","volume":"122","author":"Li Y.F.","year":"2009","journal-title":"Chin Med J (Engl)."},{"key":"bibr11-tj.5000287","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903216838"},{"key":"bibr12-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0805-8"},{"key":"bibr13-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22398"},{"key":"bibr14-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030513"},{"key":"bibr15-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880401)61:7<1441::AID-CNCR2820610727>3.0.CO;2-C"},{"key":"bibr16-tj.5000287","first-page":"555","volume":"22","author":"Su DL","year":"2006","journal-title":"Immunol J."},{"key":"bibr17-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-128397"},{"key":"bibr18-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-007-0629-y"},{"key":"bibr19-tj.5000287","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.52"},{"issue":"1","key":"bibr20-tj.5000287","first-page":"42","volume":"13","author":"Li Y.F.","year":"2004","journal-title":"Leuk Lymphoma(chinese)."}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/tj.5000287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T17:24:46Z","timestamp":1741109086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/tj.5000287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.5301\/tj.5000287"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000287","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"type":"print","value":"0300-8916"},{"type":"electronic","value":"2038-2529"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}