{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:47:06Z","timestamp":1761562026309,"version":"3.38.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p> Multiple myeloma is the second most common hematological neoplasm that also affects young patients. The progression-free survival after autologous stem cell transplant has improved with the introduction of several novel agents such as lenalidomide, which may, however, increase the risk of adverse events. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Abdominal plain x-ray and magnetic resonance imaging (MRI) without intravenous contrast material showed left-sided and splenic flexure acute ischemic colitis with reperfusion phenomena. Continuous intravenous infusion of unfractionated heparin was given with metronidazole and meropenem and the patient improved within a few days. MRI performed 15 days later confirmed complete recovery of ischemic colitis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> To our knowledge there have been no previously reported cases of ischemic colitis during lenalidomide therapy as a single agent in relapsed or refractory multiple myeloma, in particular promptly diagnosed by MRI. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000392","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T11:31:50Z","timestamp":1443785510000},"page":"S110-S112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Ischemic Colitis Diagnosed by Magnetic Resonance Imaging during Lenalidomide Treatment in a Patient with Relapsed Multiple Myeloma"],"prefix":"10.1177","volume":"102","author":[{"given":"Susanna","family":"Guerrini","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bucalossi","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant and Cellular Therapy Unit, Azienda Ospedaliera Universitaria Senese, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevada","family":"Cioffi Squitieri","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco G.","family":"Mazzei","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Volterrani","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Mazzei","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"bibr1-tj.5000392","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.156134"},{"key":"bibr2-tj.5000392","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.76a.08089"},{"key":"bibr3-tj.5000392","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405062"},{"key":"bibr4-tj.5000392","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.2.r99ma28381"},{"key":"bibr5-tj.5000392","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/895248"},{"issue":"11","key":"bibr6-tj.5000392","first-page":"435","volume":"103","author":"Mazzei MA","year":"2012","journal-title":"Recenti Prog Med"},{"key":"bibr7-tj.5000392","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e31823b4465"},{"key":"bibr8-tj.5000392","doi-asserted-by":"publisher","DOI":"10.1186\/2036-7902-5-S1-S6"},{"key":"bibr9-tj.5000392","doi-asserted-by":"publisher","DOI":"10.1186\/2036-7902-5-S1-S7"},{"key":"bibr10-tj.5000392","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i8.1256"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/tj.5000392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T15:08:11Z","timestamp":1741014491000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/tj.5000392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":10,"journal-issue":{"issue":"2_suppl","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.5301\/tj.5000392"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000392","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"type":"print","value":"0300-8916"},{"type":"electronic","value":"2038-2529"}],"subject":[],"published":{"date-parts":[[2016,11]]}}}