{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:38:59Z","timestamp":1741066739081,"version":"3.38.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Scanty data exist on the role of personal medical conditions, except for gallstones, and family history of cancer on the risk of biliary tract cancers (BTC). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We analyzed this issue using data from two Italian case-control studies, including 159 cases of BTC and 795 matched hospital controls. Odds ratios (ORs) of BTC and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression models. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Gallstones were associated with a 2-fold excess risk of BTC (95% CI 1.24-3.45). No significant associations were observed with other conditions investigated, including diabetes (OR 1.15, 95% CI 0.63-2.11), hypertension (OR 0.65, 95% CI 0.39-1.11), hyperlipidemia (OR 0.61, 95% CI 0.31-1.21), allergy (OR 0.64, 95% CI 0.29-1.40), gastroduodenal ulcer (OR 0.52, 95% CI 0.24-1.12), hepatitis (OR 2.02, 95% CI 0.35-11.67), benign thyroid diseases (OR 1.16, 95% CI 0.56-2.40), hysterectomy (OR 1.19, 95% CI 0.53-2.68), unilateral oophorectomy (OR 1.75, 95% CI 0.44-6.93), and bilateral oophorectomy (OR 2.48, 95% CI 0.79-7.82). We found an excess risk of BTC in relation to family history of any cancer (OR 1.52, 95% CI 1.03-2.24) and family history of gallbladder cancer (OR 3.83, 95% CI 0.59-24.75). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The present study confirms a strong association between BTC and history of gallstones, and provides further evidence of a positive association with family history of cancer. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000397","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T11:31:50Z","timestamp":1443785510000},"page":"252-257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Medical Conditions, Family History of Cancer, and the Risk of Biliary Tract Cancers"],"prefix":"10.1177","volume":"102","author":[{"given":"Valentina","family":"Rosato","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Mario Negri Institute for Pharmacological Research, IRCCS, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bosetti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mario Negri Institute for Pharmacological Research, IRCCS, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dal Luigino","family":"Maso","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute IRCCS, Aviano (Pordenone) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Montella","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology, National Cancer Institute \u201cG. 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