{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T16:23:42Z","timestamp":1768667022527,"version":"3.49.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,3,8]],"date-time":"2015-03-08T00:00:00Z","timestamp":1425772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p> To elucidate whether breast imaging can predict final histologic diagnosis of lesions of uncertain malignant potential diagnosed at ultrasound core needle biopsy (CNB). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> The imaging characteristics (mammography, ultrasound, and magnetic resonance imaging [MRI]) of lesions of uncertain malignant potential in the breast that were obtained by ultrasound CNB were retrospectively analyzed in 87 women. Radiologic characteristics of lesions were compared to definitive histopathologic findings. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Out of 87 breast lesions of uncertain malignant potential, 27 (31%) were diagnosed as papillary lesions, 24 (28%) atypical ductal hyperplasia, 19 (22%) lobular intraepithelial neoplasia, 9 (10%) phyllodes tumors, 3 (3%) radial sclerosing lesions, and 5 (6%) unspecified lesions of uncertain malignant potential. The underestimation rate of malignancy at CNB based on the total number of lesions on final follow-up was 22%. Using multivariate logistic regression, Breast Imaging-Reporting and Data System (BI-RADS) score (odds ratio [OR] = 12.29, p = 0.027) and G\u00f6ttingen MRI scoring system (OR = 8.1, p = 0.008) were found to be independent predictors of malignancy. Receiver operating characteristic analysis showed that G\u00f6ttingen MRI score &gt;3 provides a plausibly good cutoff value with sensitivity of 100 (95% confidence interval [CI] 74%-100%) and specificity of 76% (95% CI 61%-88%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Lesions of uncertain malignant potential classified as BI-RADS 5 and G\u00f6ttingen score 4 or higher are at significantly higher risk of harboring malignancy and therefore should be recommended for surgical excision. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000398","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T11:31:50Z","timestamp":1443785510000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of Breast Imaging in Predicting Outcome of Lesions of Uncertain Malignant Potential (B3) Diagnosed at Core Needle Biopsy"],"prefix":"10.1177","volume":"102","author":[{"given":"Marko","family":"Petrovecki","sequence":"first","affiliation":[{"name":"Department of Radiology, Clinical Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb - Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Marija","family":"Alduk","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb - Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasminka","family":"Jakic-Razumovic","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology, Clinical Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb - Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranka","family":"Stern-Padovan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb - Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinko","family":"Bubic","sequence":"additional","affiliation":[{"name":"Community Health Center East, Zagreb - Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Prutki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb - Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,3,8]]},"reference":[{"key":"bibr1-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.180.2.1648757"},{"key":"bibr2-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.2.7972743"},{"key":"bibr3-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.1.8090927"},{"key":"bibr4-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(05)70201-3"},{"key":"bibr5-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200104000-00009"},{"key":"bibr6-tj.5000398","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.155.5.2120967"},{"key":"bibr7-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm481"},{"key":"bibr8-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03786.x"},{"key":"bibr9-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2010.12.003"},{"key":"bibr10-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25801"},{"key":"bibr11-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1308\/003588412X13171221498460"},{"key":"bibr12-tj.5000398","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2003.10.008"},{"key":"bibr13-tj.5000398","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.2.9242745"},{"key":"bibr14-tj.5000398","unstructured":"ACR Breast Imaging Reporting and Data System, Breast Imaging Atlas. 5th ed. 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