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In the last two decades a deeper understanding of mesothelioma carcinogenesis and invasiveness mechanisms has prompted research efforts to test new agents in patients with malignant pleural mesothelioma, but the results have been modest. Attractive preclinical data disappointed in subsequent experimental phases. Other promising agents failed to improve patient outcomes due to high toxicity. Interesting suggestions have come from preliminary data on immunotherapy. Several trials are ongoing and the results are eagerly awaited. The aim of this review is to discuss the most recent news on systemic therapy for advanced malignant pleural mesothelioma. <\/jats:p>","DOI":"10.5301\/tj.5000436","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T17:51:06Z","timestamp":1445363466000},"page":"18-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Systemic Approach to Malignant Pleural Mesothelioma: What News of                     Chemotherapy, Targeted Agents and Immunotherapy?"],"prefix":"10.1177","volume":"102","author":[{"given":"Diego","family":"Signorelli","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Fondazione\r                IRCCS Istituto Nazionale dei Tumori, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Macerelli","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fondazione\r    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