{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T06:09:48Z","timestamp":1740895788666,"version":"3.38.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Hepatosplenic T-cell lymphoma (HSTL) is a rare extranodal and systemic lymphoma derived from cytotoxic T cells usually of \u03b3\u03b4 T cell receptor type. It is characterized by primary extranodal disease with typical sinusoidal infiltration of liver, spleen, and bone marrow by medium-sized lymphoid cells. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p> A 29-year-old man, with no significant prior medical history, presented with fever and massive splenomegaly. A diagnosis of HSTL was established by histologic examination and immunohistochemistry. Staging workup demonstrated bone marrow involvement by lymphoma. In addition, the patient was found to have hepatitis B infection. The association of these 2 entities has been described rarely. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Hepatosplenic T-cell lymphoma is a distinct T cell lymphoma associated with an aggressive clinical course, a poor response to conventional treatment, and an exceedingly high mortality rate. An association of HSTL with hepatitis B as seen in the present case is exceedingly rare, with few cases reported in the literature. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000445","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T17:51:06Z","timestamp":1445363466000},"page":"S61-S64","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatosplenic T-Cell Lymphoma with Coexistent Hepatitis B Infection: A Rare Clinicopathologic Entity"],"prefix":"10.1177","volume":"102","author":[{"given":"Fouzia","family":"Siraj","sequence":"first","affiliation":[{"name":"National Institute of Pathology (ICMR), New Delhi - India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Dalal","sequence":"additional","affiliation":[{"name":"National Institute of Pathology (ICMR), New Delhi - India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afaq A.","family":"Khan","sequence":"additional","affiliation":[{"name":"JLNM Hospital, Srinagar, Kashmir - India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepali","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology, AIIMS, New Delhi - India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"bibr1-tj.5000445","first-page":"298","volume-title":"World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissue","author":"Gaulard P","year":"2008","edition":"4"},{"issue":"6","key":"bibr2-tj.5000445","first-page":"991","volume":"14","author":"Weidmann E","year":"2000","journal-title":"A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia"},{"key":"bibr3-tj.5000445","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1675"},{"key":"bibr4-tj.5000445","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00804.x"},{"key":"bibr5-tj.5000445","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.11.2213.2213"},{"issue":"9","key":"bibr6-tj.5000445","first-page":"1453","volume":"10","author":"Jonveaux P","year":"1996","journal-title":"Leukemia"},{"key":"bibr7-tj.5000445","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2009.87"},{"key":"bibr8-tj.5000445","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21748"},{"issue":"3","key":"bibr9-tj.5000445","first-page":"215","volume":"44","author":"Ozaki S","year":"1998","journal-title":"J Med Invest"},{"issue":"4","key":"bibr10-tj.5000445","first-page":"288","volume":"15","author":"Leung VK","year":"2009","journal-title":"Hong Kong Med J"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/tj.5000445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T03:18:23Z","timestamp":1740885503000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/tj.5000445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":10,"journal-issue":{"issue":"2_suppl","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.5301\/tj.5000445"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000445","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"type":"print","value":"0300-8916"},{"type":"electronic","value":"2038-2529"}],"subject":[],"published":{"date-parts":[[2016,11]]}}}