{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:12:15Z","timestamp":1789373535550,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background and aims<\/jats:title><jats:p> The p73 gene has different isoforms with opposing anti- and pro-apoptotic functions. The pro-apoptotic activities are inhibited by overexpression of the dominant \u0394Np73 isoform. The aim of this study was to detect the expression of the TAp73 and \u0394Np73 isoforms in Egyptian patients with malignant lymphoid neoplasms. Their expression was analyzed by quantitative RT-PCR. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> The study included 30 B-NHL patients, 24 T-NHL patients, 16 ALL patients, 18 CLL patients, 22 patients with reactive lymphoid hyperplasia, and 6 healthy control subjects. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> ALL and CLL patients expressed both isoforms at higher levels compared to lymphoma patients. Higher expression of TAp73 was found in both B-NHL and T-NHL (around 4-fold and 16-fold, respectively) in comparison to \u0394Np73 (2-fold and 14-fold, respectively). In CLL patients both isoforms showed higher expression levels in comparison to normal peripheral blood lymphocytes controls: nearly 27-fold for TAp73 and 233-fold for \u0394Np73. All ALL patients showed higher expression of both studied isoforms than controls (9-fold for TAp73 and 386-fold for \u0394Np73). The highest \u0394Np73 expression along with a higher \u0394Np73\/TAp73 ratio (67-fold) was found in ALL patients compared with CLL patients (21-fold). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> A considerable number of lymphoma patients lacked the expression of either or both isoforms, while all lymphoid leukemia patients expressed both isoforms. The expression pattern differences of p73 isoforms may reflect differences in the biology of these malignancies. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000506","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T11:28:52Z","timestamp":1461324532000},"page":"268-271","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["TAp73 and \u0394Np73 Relative Expression in Egyptian Patients with Lymphoid Neoplasms"],"prefix":"10.1177","volume":"103","author":[{"given":"Mona Salah Al-Din","family":"Hamdy","sequence":"first","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo - Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab Ali","family":"El-Saadany","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo - 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