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In this article we describe the occurrence of a postradiotherapy abscopal effect in an 89-year-old patient suffering from a metastatic neuroendocrine large-cell thymic carcinoma, the first case of the abscopal effect related to a thymic carcinoma reported in the literature. Along with the description of this case, we discuss and review the main potential mechanisms of bystander and abscopal effects in solid tumors so as to enable clinicians to identify and control these effects more resourcefully in the age of immunotherapy and stereotactic radiotherapy. <\/jats:p>","DOI":"10.5301\/tj.5000616","type":"journal-article","created":{"date-parts":[[2017,3,18]],"date-time":"2017-03-18T11:16:35Z","timestamp":1489835795000},"page":"217-222","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Review of the Mechanisms Involved in the Abscopal Effect and Future Directions with a Focus on Thymic Carcinoma"],"prefix":"10.1177","volume":"103","author":[{"given":"Paul","family":"Lesueur","sequence":"first","affiliation":[{"name":"Radiotherapy Unit, Centre Fran\u00e7ois Baclesse, Caen - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Laboratory for Research with Accelerated Heavy Ions, Institute of Cellular and Molecular Radiation Biology, CEA-GANIL, Caen - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinu","family":"Stefan","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Centre Fran\u00e7ois Baclesse, Caen - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Habrand","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Centre Fran\u00e7ois Baclesse, Caen - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Lerouge","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Centre Fran\u00e7ois Baclesse, Caen - France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radj","family":"Gervais","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Centre Fran\u00e7ois Baclesse, Caen - France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"issue":"1","key":"bibr1-tj.5000616","first-page":"239","volume":"10","author":"Stewart FW","year":"1952","journal-title":"Tex Rep Biol Med"},{"key":"bibr2-tj.5000616","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195609000-00007"},{"key":"bibr3-tj.5000616","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-26-305-234"},{"key":"bibr4-tj.5000616","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(96)90023-7"},{"key":"bibr5-tj.5000616","unstructured":"O'ReganB HirshbergC Spontaneous remission: an annotated bibliography. 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