{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:11:51Z","timestamp":1778811111416,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Purpose:<\/jats:title><jats:p> To evaluate the efficacy and safety of hypofractionated radiotherapy (16 Gy in 2 fractions, 1 week apart) in patients with complicated bone metastases and poor performance status. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A prospective single-arm phase II clinical trial was conducted from July 2014 to May 2016. The primary endpoint was pain response as defined in the International Consensus on Palliative Radiotherapy Endpoints. Secondary endpoints included quality of life as measured by quality of life questionnaire (QLQ) PAL-15 and QLQ-BM22 European Organisation for Research and Treatment of Cancer guidelines, pain flare, adverse events, re-irradiation, and skeletal complications. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Fifty patients were enrolled. There were 23 men with a median age of 58 years (range 26-86). Of the 50 patients, 38 had an extraosseous soft tissue component, 18 needed postsurgical radiation, 3 had neuropathic pain, and 3 had an impending fracture in a weight-bearing bone. At 2 months, 33 patients were alive (66%). Four (12.5%) had a complete response and 12 (37.5%) had a partial response. A statistically significant improvement was seen in the functional interference (p = 0.01) and psychosocial aspects (p = 0.03) of the BM22. No patient had spinal cord compression. One patient required surgery for pathologic fracture, and another re-irradiation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Hypofractionated radiotherapy (16 Gy in 2 fractions of 8 Gy 1 week apart) achieved satisfactory pain relief and safety results in patients with complicated bone metastases and poor performance status. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000658","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T13:43:15Z","timestamp":1498830195000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypofractionated radiotherapy for complicated bone metastases in patients with poor performance status: a phase II international trial"],"prefix":"10.1177","volume":"105","author":[{"given":"Mauricio F.","family":"Silva","sequence":"first","affiliation":[{"name":"Radiation Oncology Unit, Hospital de Caridade Astrogildo de Azevedo, Santa Maria, Rio Grande do Sul - Brazil"},{"name":"Radiation Oncology Department, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Porto Alegre, Rio Grande do Sul - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo N.","family":"Marta","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo - Brazil"},{"name":"Department of Radiology and Oncology of University of S\u00e3o Paulo, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP), Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe P.C.","family":"Lisboa","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Porto Alegre, Rio Grande do Sul - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Watte","sequence":"additional","affiliation":[{"name":"Radiology Department, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, Merseyside - United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Trippa","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, \u201cS. Maria\u201d Hospital, Terni - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Maranzano","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, \u201cS. Maria\u201d Hospital, Terni - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neiro W.","family":"da Motta","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Porto Alegre, Rio Grande do Sul - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Popovic","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto - Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan","family":"Ha","sequence":"additional","affiliation":[{"name":"Radiation Oncology Centres, Fraser Coast, Queensland - Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Burmeister","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Princess Alexandra Hospital, Brisbane, Queensland - Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Chow","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto - Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"bibr1-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.5281"},{"key":"bibr2-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.11.026"},{"key":"bibr3-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1586\/era.10.32"},{"issue":"3","key":"bibr4-tj.5000658","first-page":"192","volume":"3","author":"Jones JA","year":"2014","journal-title":"Ann Palliat Med"},{"key":"bibr5-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00128-4"},{"key":"bibr6-tj.5000658","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2012_082"},{"key":"bibr7-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.02.008"},{"key":"bibr8-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.05.028"},{"key":"bibr9-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1160-6"},{"key":"bibr10-tj.5000658","first-page":"357","volume":"35","author":"Harrington KD.","year":"1986","journal-title":"Instr Course Lect"},{"key":"bibr11-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00952-8"},{"key":"bibr12-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910515)67:10<2472::AID-CNCR2820671014>3.0.CO;2-V"},{"key":"bibr13-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00572-G"},{"key":"bibr14-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20633"},{"key":"bibr15-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.09.017"},{"key":"bibr16-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.013"},{"key":"bibr17-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.001"},{"key":"bibr18-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.193"},{"key":"bibr19-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.05.012"},{"key":"bibr20-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.044"},{"key":"bibr21-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2014.11.001"},{"key":"bibr22-tj.5000658","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.129.6.1095"},{"key":"bibr23-tj.5000658","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.3.222"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/tj.5000658","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T22:33:41Z","timestamp":1740782021000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/tj.5000658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.5301\/tj.5000658"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000658","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,8]]}}}