{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T06:06:58Z","timestamp":1738044418708,"version":"3.33.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The purpose of this study was to investigate the clinical outcomes and prognostic factors of concurrent chemoradiotherapy (CCRT) for locally recurrent biliary tract cancer (BTC) after curative surgical resection. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We performed a retrospective cohort study of patients with locally recurrent BTC treated with CCRT between October 2004 and December 2013. The study included and analyzed 42 patients with a history of curative-intent surgical resection of confirmed adenocarcinoma originating from the biliary tract. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The median time to recurrence after surgery was 16.1 months (range, 4.5-77.8 months). Median follow-up after CCRT was 26.9 months (range, 5.2-81.9) with no grade 3 or higher gastrointestinal toxicities. Analysis of the first site of failure showed local progression (LP) developed in 20 patients (47.6%); among these, 16 (38.1%) had isolated LP. The median values were 15.8 months (range, 1.7-81.7) for LP-free survival (LPFS), 10.6 months (range, 1.7 - 81.7) for progression-free survival (PFS) and 41.2 months (range, 5.2-81.9) for overall survival (OS). Multivariate analysis showed that the level of pre-CCRT carbohydrate antigen (CA) 19-9 and the chemotherapy regimen were significant prognostic factors for LPFS and PFS; pT stage was the only significant prognostic factor for OS. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> CCRT for locally recurrent BTC showed promising outcomes as a salvage modality, but LP was still frequent. The pre-CCRT CA 19-9 level and the chemotherapy regimen were prognostic factors for LPFS and PFS. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000666","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T14:03:20Z","timestamp":1500041000000},"page":"345-352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes of Salvage Chemoradiotherapy for Locally Recurrent Biliary Tract Cancer"],"prefix":"10.1177","volume":"103","author":[{"given":"Jeong Il","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"},{"name":"Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hoon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Oh","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Suk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Wook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Woong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Seok","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul - Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"doi-asserted-by":"publisher","key":"bibr1-tj.5000666","DOI":"10.3322\/caac.21332"},{"doi-asserted-by":"publisher","key":"bibr2-tj.5000666","DOI":"10.1097\/01.sla.0000251366.62632.d3"},{"doi-asserted-by":"publisher","key":"bibr3-tj.5000666","DOI":"10.1097\/01.pas.0000160978.77833.d7"},{"doi-asserted-by":"publisher","key":"bibr4-tj.5000666","DOI":"10.1097\/01.sla.0000150166.94732.88"},{"doi-asserted-by":"publisher","key":"bibr5-tj.5000666","DOI":"10.1002\/cncr.11699"},{"doi-asserted-by":"publisher","key":"bibr6-tj.5000666","DOI":"10.3857\/roj.2014.32.2.63"},{"doi-asserted-by":"publisher","key":"bibr7-tj.5000666","DOI":"10.1016\/j.ijrobp.2006.05.061"},{"doi-asserted-by":"publisher","key":"bibr8-tj.5000666","DOI":"10.3857\/roj.2014.32.3.163"},{"doi-asserted-by":"publisher","key":"bibr9-tj.5000666","DOI":"10.1007\/s00534-011-0494-2"},{"doi-asserted-by":"publisher","key":"bibr10-tj.5000666","DOI":"10.1016\/S0360-3016(02)02845-6"},{"doi-asserted-by":"publisher","key":"bibr11-tj.5000666","DOI":"10.1016\/j.ijrobp.2008.07.008"},{"doi-asserted-by":"publisher","key":"bibr12-tj.5000666","DOI":"10.3857\/roj.2015.33.4.337"},{"doi-asserted-by":"publisher","key":"bibr13-tj.5000666","DOI":"10.3857\/roj.2015.33.4.265"},{"doi-asserted-by":"publisher","key":"bibr14-tj.5000666","DOI":"10.1200\/JCO.2015.61.3778"},{"doi-asserted-by":"publisher","key":"bibr15-tj.5000666","DOI":"10.1245\/s10434-008-9998-7"},{"doi-asserted-by":"publisher","key":"bibr16-tj.5000666","DOI":"10.1097\/01.coc.0000245467.97180.78"},{"doi-asserted-by":"publisher","key":"bibr17-tj.5000666","DOI":"10.1016\/S0360-3016(99)00472-1"},{"doi-asserted-by":"publisher","key":"bibr18-tj.5000666","DOI":"10.1097\/SLA.0000000000000827"},{"doi-asserted-by":"publisher","key":"bibr19-tj.5000666","DOI":"10.1245\/s10434-014-4146-z"},{"doi-asserted-by":"publisher","key":"bibr20-tj.5000666","DOI":"10.1016\/j.radonc.2009.11.004"},{"doi-asserted-by":"publisher","key":"bibr21-tj.5000666","DOI":"10.1016\/j.radonc.2010.03.013"},{"doi-asserted-by":"publisher","key":"bibr22-tj.5000666","DOI":"10.1200\/JCO.2014.60.2219"},{"issue":"12","key":"bibr23-tj.5000666","first-page":"6901","volume":"35","author":"Abrams M.J.","year":"2015","journal-title":"Anticancer Res."},{"doi-asserted-by":"publisher","key":"bibr24-tj.5000666","DOI":"10.2478\/raon-2013-0065"},{"doi-asserted-by":"publisher","key":"bibr25-tj.5000666","DOI":"10.1093\/jnci\/djv248"},{"doi-asserted-by":"publisher","key":"bibr26-tj.5000666","DOI":"10.1634\/theoncologist.12-2-152"},{"doi-asserted-by":"publisher","key":"bibr27-tj.5000666","DOI":"10.1002\/med.20159"},{"doi-asserted-by":"publisher","key":"bibr28-tj.5000666","DOI":"10.1186\/1471-2407-10-564"},{"doi-asserted-by":"publisher","key":"bibr29-tj.5000666","DOI":"10.1186\/1471-2407-11-188"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/tj.5000666","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/tj.5000666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T02:44:37Z","timestamp":1738032277000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/tj.5000666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.5301\/tj.5000666"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000666","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"type":"print","value":"0300-8916"},{"type":"electronic","value":"2038-2529"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}