{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:27:09Z","timestamp":1760898429366,"version":"3.38.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is an exceedingly rare entity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> The clinical records of two patients with primary carcinoma ex-pleomorphic adenoma of the parapharyngeal space surgically treated at two different centers were retrospectively analyzed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Despite ultrasound-guided fine-needle aspiration cytology and magnetic resonance imaging, the correct diagnosis was preoperatively missed in both cases. Excision was obtained through a transcervical-transparotid approach in 1 case and a minimally-invasive endoscopic-assisted transcervical approach in the other. Definitive histology was consistent with intracapsular carcinoma ex-pleomorphic adenoma. Adjuvant radiotherapy was performed in the case with macroscopic malignant degeneration; both patients are alive and free from disease 36 months after surgery. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is a rare disease, and definitive diagnosis may be challenging. Surgery is the mainstay of treatment, but adjuvant radiotherapy also may be required in the presence of specific risk factors. <\/jats:p><\/jats:sec>","DOI":"10.5301\/tj.5000688","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T13:13:46Z","timestamp":1510924426000},"page":"S73-S77","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Intracapsular Carcinoma Ex-Pleomorphic Adenoma of the Parapharyngeal Space: Report of Two Cases and Review of the Literature"],"prefix":"10.1177","volume":"103","author":[{"given":"Remo","family":"Accorona","sequence":"first","affiliation":[{"name":"Unit of Otorhinolaryngology \u2013 Head and Neck Surgery, University of Brescia, Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Departmente of Otorhinolaryngology, S. Raffaele \u201cVita e Salute\u201d School of Medicine, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Farina","sequence":"additional","affiliation":[{"name":"Unit of Radiology, University of Brescia, Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology \u2013 Head and Neck Surgery, University of Brescia, Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bussi","sequence":"additional","affiliation":[{"name":"Departmente of Otorhinolaryngology, S. Raffaele \u201cVita e Salute\u201d School of Medicine, Milan - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology \u2013 Head and Neck Surgery, University of Brescia, Brescia - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"doi-asserted-by":"publisher","key":"bibr1-TJ.5000688","DOI":"10.1016\/j.otc.2007.10.012"},{"doi-asserted-by":"publisher","key":"bibr2-TJ.5000688","DOI":"10.1016\/j.oraloncology.2014.02.007"},{"doi-asserted-by":"publisher","key":"bibr3-TJ.5000688","DOI":"10.1002\/lary.25077"},{"doi-asserted-by":"publisher","key":"bibr4-TJ.5000688","DOI":"10.1007\/s00405-015-3545-5"},{"doi-asserted-by":"publisher","key":"bibr5-TJ.5000688","DOI":"10.1007\/s00428-015-1887-4"},{"doi-asserted-by":"publisher","key":"bibr6-TJ.5000688","DOI":"10.3174\/ajnr.A1412"},{"doi-asserted-by":"publisher","key":"bibr7-TJ.5000688","DOI":"10.1259\/bjr.20140685"},{"doi-asserted-by":"publisher","key":"bibr8-TJ.5000688","DOI":"10.1097\/MOO.0000000000000134"},{"doi-asserted-by":"publisher","key":"bibr9-TJ.5000688","DOI":"10.1017\/S0022215114002965"},{"doi-asserted-by":"publisher","key":"bibr10-TJ.5000688","DOI":"10.1245\/s10434-016-5356-3"},{"doi-asserted-by":"publisher","key":"bibr11-TJ.5000688","DOI":"10.1002\/hed.23940"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/TJ.5000688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/TJ.5000688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T11:07:32Z","timestamp":1741000052000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/TJ.5000688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":11,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.5301\/TJ.5000688"],"URL":"https:\/\/doi.org\/10.5301\/tj.5000688","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"type":"print","value":"0300-8916"},{"type":"electronic","value":"2038-2529"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}