{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:25:47Z","timestamp":1741152347409,"version":"3.38.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,9,7]],"date-time":"2014-09-07T00:00:00Z","timestamp":1410048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p> Sunitinib therapy showed an improvement in survival of patients with metastatic renal cell carcinoma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p> A 51-year-old man, with Eastern Cooperative Oncology Group Score (ECOG) of 0, presented at our Institute in March 2012 for macrohematuria and urinary retention. A computed tomography (CT) scan of the abdomen showed a right renal lesion. The lesion had a diameter of 15 cm and was developing towards the liver, in the absence of cleavage planes between the liver and kidney. A 12 mm finding, suspected as secondary lesion, was detected at the level of the VII hepatic segment. Neoadjuvant chemotherapy with Sunitinib was proposed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The patient underwent a ultrasound-guided biopsy, which confirmed the presence of Clear Cell Carcinoma. The patient began chemotherapy treatment in May 2012 according to the scheme SUNITINIB 50 mg daily for 4 weeks every 6 weeks. After four courses of treatment, according to RECIST criteria for solid tumors, 40% (9 cm vs 15 cm) regression of the primary tumor and 33% (8 mm vs 12 mm) regression of the secondary lesion were observed at a CT scan of the abdomen. In February 2013, Laparoscopic Adrenal-Sparing Radical Nephrectomy was performed. At a follow-up of 3 months, performed with a thorax and abdomen CT scans, there was a complete remission of hepatic secondary lesion and no areas of secondary localization of disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> This case report showed the effectiveness of neoadjuvant chemotherapy with Sunitinib. The use of this chemotherapy agent can change the approach to the management of cRCC. <\/jats:p><\/jats:sec>","DOI":"10.5301\/uro.5000077","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T09:53:59Z","timestamp":1405936439000},"page":"109-113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoadjuvant Sunitinib Effectiveness in T4 Renal Clear Cell Carcinoma: A Case Report"],"prefix":"10.1177","volume":"82","author":[{"given":"Stefano","family":"Ricciardulli","sequence":"first","affiliation":[{"name":"Department of Urology, University G. D'annunzio, Chieti - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Del Biondo","sequence":"additional","affiliation":[{"name":"Department of Urology, San Bassiano Hospital, Bassano del Grappa (Vicenza) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calogero","family":"Cicero","sequence":"additional","affiliation":[{"name":"Department of Radiology, San Bassiano Hospital, Bassano del Grappa (Vicenza) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genesio","family":"Leo","sequence":"additional","affiliation":[{"name":"Department of Pathology, San Bassiano Hospital, Bassano del Grappa (Vicenza) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Zeccolini","sequence":"additional","affiliation":[{"name":"Department of Urology, San Bassiano Hospital, Bassano del Grappa (Vicenza) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Celia","sequence":"additional","affiliation":[{"name":"Department of Urology, San Bassiano Hospital, Bassano del Grappa (Vicenza) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,9,7]]},"reference":[{"key":"bibr1-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2012.03065.x"},{"key":"bibr2-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000110610.61545.ae"},{"key":"bibr3-uro.5000077","first-page":"444","volume":"16","author":"Mizutani Y.","year":"2009","journal-title":"Urol."},{"key":"bibr4-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.05.035"},{"key":"bibr5-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.05.041"},{"key":"bibr6-uro.5000077","first-page":"228","volume":"45","author":"Eisenhauera E.A.","year":"2009","journal-title":"Can."},{"key":"bibr7-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.028"},{"key":"bibr8-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2011.02.003"},{"key":"bibr9-uro.5000077","first-page":"307","volume":"58","author":"Rodriguez Faba O.","year":"2010","journal-title":"Urol."},{"key":"bibr10-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.12.036"},{"key":"bibr11-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24240"},{"key":"bibr12-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.04.018"},{"key":"bibr13-uro.5000077","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.58.95"},{"key":"bibr14-uro.5000077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07660.x"}],"container-title":["Urologia Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/uro.5000077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/uro.5000077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/uro.5000077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T07:35:47Z","timestamp":1741073747000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/uro.5000077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,7]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.5301\/uro.5000077"],"URL":"https:\/\/doi.org\/10.5301\/uro.5000077","relation":{},"ISSN":["0391-5603","1724-6075"],"issn-type":[{"type":"print","value":"0391-5603"},{"type":"electronic","value":"1724-6075"}],"subject":[],"published":{"date-parts":[[2014,9,7]]}}}