{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:46:21Z","timestamp":1762004781718,"version":"3.38.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Transperineal prostate biopsy (STPB) is associated with an improved cancer detection rate and an increase in anterior and apical prostate cancers compared to standard transrectal biopsy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> A total of 48 men with at least two sets of prior prostate biopsies underwent transrectal ultrasound-guided STPB. Prostate rebiopsy indications were serum prostate-specific antigen (PSA) levels greater than 2.5 ng\/mL and\/or abnormal digital rectal examination and\/or presence of high-grade prostatic intraepithelial neoplasia (HGPIN; \u22652 cores) or atypical small acinar proliferation (ASAP) at previous biopsies. The procedure was performed at dorsal lithotomy position under general anesthesia using a perineal 0.5 cm brachytherapy template attached to the transrectal ultrasound probe. Specimens from each zone were sent separately for pathological examination. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Mean PSA level at STPB was 15.9 ng\/mL (range 4.03 to 59.57). An average of 54.5 cores was obtained. Prostate adenocarcinoma was detected in 15 of 48 (31%) patients. Mean percentage of malignant cores was 11.9%. Multivariate logistic regression analysis revealed that age and presence of ASAP or HGPIN at previous biopsies were independent predictors of prostate cancer (p&lt;0.05). No major complications, including sepsis and severe urinary or rectal bleeding, were observed in any of the patients. Five patients (10%) developed acute urinary retention after the procedure requiring urethral catheterization. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Considerable number of patients with negative multiple biopsies were diagnosed with prostate cancer. STPB is a well-tolerated procedure with minimal morbidity, which can be considered for the diagnosis of prostate cancer in patients with previous negative biopsies. <\/jats:p><\/jats:sec>","DOI":"10.5301\/uro.5000159","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T10:02:29Z","timestamp":1452247349000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictors of Prostate Cancer in Ultrasound-Guided Transperineal Saturation Biopsy in Turkish Men with Multiple Prior Negative Biopsies"],"prefix":"10.1177","volume":"83","author":[{"given":"Sertac","family":"Yazici","sequence":"first","affiliation":[{"name":"Department of Urology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Kiziloz","sequence":"additional","affiliation":[{"name":"Department of Urology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Cansu","family":"Bozaci","sequence":"additional","affiliation":[{"name":"Department of Urology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek Ertoy","family":"Baydar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Del Biondo","sequence":"additional","affiliation":[{"name":"Department of Urology, San Bassiano Hospital, Bassano del Grappa (Vicenza) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haluk","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of Urology, Hacettepe University School of Medicine, Ankara - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"bibr1-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38663-9"},{"issue":"1","key":"bibr2-uro.5000159","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-5347(05)67995-5","volume":"163","author":"Presti JC","year":"2000","journal-title":"J Urol"},{"key":"bibr3-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.05.033"},{"key":"bibr4-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05801.x"},{"key":"bibr5-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2005.01041.x"},{"key":"bibr6-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08744.x"},{"issue":"1","key":"bibr7-uro.5000159","first-page":"61","volume":"59","author":"Heidenreich A","year":"2011","journal-title":"Part 1: screening, diagnosis, and treatment of clinically localised disease Eur Urol"},{"key":"bibr8-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2009.46"},{"issue":"5","key":"bibr9-uro.5000159","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0022-5347(05)65652-2","volume":"166","author":"Djavan B","year":"2001","journal-title":"J Urol"},{"issue":"5","key":"bibr10-uro.5000159","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/S0022-5347(01)67444-5","volume":"153","author":"Ellis WJ","year":"1995","journal-title":"J Urol"},{"key":"bibr11-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1177\/107327481001700402"},{"key":"bibr12-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06728.x"},{"key":"bibr13-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00211-9"},{"key":"bibr14-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.01.049"},{"key":"bibr15-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64051-7"},{"key":"bibr16-uro.5000159","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.11.024"},{"issue":"9","key":"bibr17-uro.5000159","first-page":"886","volume":"89","author":"Bott SR","year":"2002","journal-title":"Anterior prostate cancer: is it more difficult to diagnose? 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