{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:52:20Z","timestamp":1761519140503,"version":"3.33.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,4,12]],"date-time":"2015-04-12T00:00:00Z","timestamp":1428796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Urologia"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p> Male patients with congenital adrenal hyperplasia (CAH) may develop bilateral testicular adrenal rest tumours (TARTs). These tumours, in most cases, regress with glucocorticoid therapy and their histological differentiation from Leydig-cell tumors is quite difficult. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p> The aim of this study was to differentiate the histological and clinical features of the TARTs from those of the Leydig-cell tumours. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> The authors report a case of bilateral Leydig-cell tumour associated with giant bilateral adrenal myelolipoma in a male with adrenogenital syndrome who was submitted to a bilateral orchiectomy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Testicular neoplasia continue to grow despite adequate hormonal treatment and a bilateral orchiectomy was performed. The histopathological examination of the specimen ultimately confirmed the diagnosis of bilateral Leydig-cell tumour. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> This case shows the importance of all the relevant examinations, blood chemistry analysis, and instrumental tests in the differential diagnosis of TARTs and other testicular tumours. <\/jats:p><\/jats:sec>","DOI":"10.5301\/uro.5000162","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T09:49:51Z","timestamp":1450086591000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Leydig Cell Tumour and Giant Adrenal Myelolipoma Associated with                     Adrenogenital Syndrome: A Case Report with a Review of the                     Literature"],"prefix":"10.1177","volume":"83","author":[{"given":"Vincenzo M.","family":"Altieri","sequence":"first","affiliation":[{"name":"Department of Urology, Romolo Hospital,\r                Rocca di Neto (Crotone) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Altieri","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University\r                \u201cCattolica del Sacro Cuore\u201d, Rome - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Castellucci","sequence":"additional","affiliation":[{"name":"Department of Urology, Humanitas Gavazzeni\r                Hospital, Bergamo - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Alba","sequence":"additional","affiliation":[{"name":"Department of Urology, Romolo Hospital,\r                Rocca di Neto (Crotone) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bottone","sequence":"additional","affiliation":[{"name":"Department of Urology, Romolo Hospital,\r                Rocca di Neto (Crotone) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Fragal\u00e0","sequence":"additional","affiliation":[{"name":"Department of Urology, Romolo Hospital,\r                Rocca di Neto (Crotone) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Mirone","sequence":"additional","affiliation":[{"name":"Urology Division, University Federico II of\r                Naples, Naples - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Urology, Romolo Hospital,\r                Rocca di Neto (Crotone) - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,4,12]]},"reference":[{"issue":"3","key":"bibr1-uro.5000162","first-page":"487","volume":"34","author":"Plaut A","year":"1958","journal-title":"Am J Pathol"},{"key":"bibr2-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199602000-00066"},{"issue":"5","key":"bibr3-uro.5000162","first-page":"665","volume":"73","author":"Olsson CA","year":"1973","journal-title":"Surgery"},{"key":"bibr4-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.9.707"},{"issue":"5","key":"bibr5-uro.5000162","first-page":"338","volume":"314","author":"Umpierrez MB","year":"1997","journal-title":"Am J Med Sci"},{"issue":"2","key":"bibr6-uro.5000162","first-page":"71","volume":"3","author":"Daneshmand S","year":"2006","journal-title":"Urol J"},{"issue":"7","key":"bibr7-uro.5000162","first-page":"503","volume":"12","author":"Rutgers JL","year":"1988","journal-title":"A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders. Am J Surg Pathol"},{"key":"bibr8-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1210\/endo-26-3-385"},{"key":"bibr9-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8090"},{"key":"bibr10-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0201"},{"issue":"3","key":"bibr11-uro.5000162","first-page":"378","volume":"18","author":"Mesiano S","year":"1997","journal-title":"Endocr Rev"},{"key":"bibr12-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112989"},{"key":"bibr13-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800309"},{"key":"bibr14-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199501000-00010"},{"key":"bibr15-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.09.007"},{"key":"bibr16-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70099-9"},{"issue":"12","key":"bibr17-uro.5000162","first-page":"4583","volume":"92","author":"Martinez-Aguayo A","year":"2007","journal-title":"Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia. J Clin Endocrinol Metab"},{"key":"bibr18-uro.5000162","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1311"},{"key":"bibr19-uro.5000162","first-page":"pp4","author":"Albers P","year":"2011","journal-title":"In: European Association of Urology Guidelines"}],"container-title":["Urologia Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/uro.5000162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.5301\/uro.5000162","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/uro.5000162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T10:56:44Z","timestamp":1728471404000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/uro.5000162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,12]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.5301\/uro.5000162"],"URL":"https:\/\/doi.org\/10.5301\/uro.5000162","relation":{},"ISSN":["0391-5603","1724-6075"],"issn-type":[{"type":"print","value":"0391-5603"},{"type":"electronic","value":"1724-6075"}],"subject":[],"published":{"date-parts":[[2015,4,12]]}}}