{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T06:08:54Z","timestamp":1740809334732,"version":"3.38.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The aim of this work was to assess the effect of statin therapy on inflammatory and fibrinolytic\/endothelial (dys)function markers in end-stage renal disease (ESRD) patients under hemodialysis (HD), according to the type of vascular access. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> This transversal study includes 191 ESRD patients under regular HD, divided into four groups according to vascular access and statin therapy: 87 patients with arteriovenous fistula (AVF) and no statins (AVF-NS), 61 with AVF and statins (AVF-S), 27 with central venous dialysis catheter (CVC) and no statins (CVC-NS) and 16 with CVC and statins (CVC-S). The basic lipid profile and fibrinolytic\/endothelial cell function markers were assessed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Patients with CVC presented significantly higher levels of D-dimers compared with AVF groups. CVC-NS patients also presented the highest IL-6 values, which were significantly higher than those presented by CVC-S patients. AVF-S patients presented significantly higher t-PA and PAI-1 values and lower adiponectin levels compared with AVF-NS. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Our results demonstrate that patients with CVC, particularly those not under statin therapy, present a higher production and turnover of fibrin. We also found that statin therapy decreases inflammation in CVC patients but is associated with a reduction of adiponectin and increased endothelial function marker levels in AVF patients. <\/jats:p><\/jats:sec>","DOI":"10.5301\/jva.5000132","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T11:27:59Z","timestamp":1367580479000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Vascular Access versus the Effect of Statins on Inflammation and Fibrinolysis in Renal Dialysis Patients"],"prefix":"10.1177","volume":"14","author":[{"given":"Maria","family":"do Sameiro Faria","sequence":"first","affiliation":[{"name":"FMC, Dinefro \u2013 Di\u00e1lises e Nefrologia, SA \u2013 Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto, Porto - Portugal"}]},{"given":"Sandra","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Faculdade Farm\u00e1cia, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade do Porto, Porto - Portugal"},{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto - Portugal"}]},{"given":"Petronila","family":"Rocha-Pereira","sequence":"additional","affiliation":[{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto - Portugal"},{"name":"Centro Investiga\u00e7\u00e3o Ci\u00eancias Sa\u00fade (CICS), Universidade Beira Interior, Covilh\u00e3 - Portugal"}]},{"given":"Vasco","family":"Miranda","sequence":"additional","affiliation":[{"name":"FMC, Dinefro \u2013 Di\u00e1lises e Nefrologia, SA \u2013 Portugal"}]},{"given":"Alexandre","family":"Quintanilha","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto, Porto - Portugal"},{"name":"Instituto 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Portugal"}]},{"given":"Alice","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Faculdade Farm\u00e1cia, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade do Porto, Porto - Portugal"},{"name":"Instituto Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto - Portugal"}]}],"member":"179","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"bibr1-jva.5000132","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.1.17"},{"key":"bibr2-jva.5000132","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2002.kid556.x"},{"key":"bibr3-jva.5000132","first-page":"545","volume":"29","year":"2000","journal-title":"Dial 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