{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:04:17Z","timestamp":1780113857761,"version":"3.54.0"},"reference-count":14,"publisher":"Japan Society of Plastic and Reconstructive Surgery","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPRS"],"published-print":{"date-parts":[[2026,5,27]]},"DOI":"10.53045\/jprs.2025-0027","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:07:14Z","timestamp":1755036434000},"page":"208-213","source":"Crossref","is-referenced-by-count":0,"title":["Successful Management of Neonatal Purpura Fulminans Caused by Congenital Protein C Deficiency: A Case Report"],"prefix":"10.53045","volume":"5","author":[{"given":"Makiko","family":"Shiraishi","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Osaka Women's and Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Osaka Women's and Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31107","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Goldenberg NA, Manco-Johnson MJ. Protein C deficiency. Haemophilia. 2008 Nov; 14 (6): 1214-21.","DOI":"10.1111\/j.1365-2516.2008.01838.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Mahasandana C, Suvatte V, Chuansumrit A, et al. Homozygous protein S deficiency in an infant with purpura fulminans. J Pediatr. 1990 Nov; 117 (5): 750-3.","DOI":"10.1016\/S0022-3476(05)83335-9"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Manco-Johnson MJ, Abshire TC, Jacobson LJ, et al. Severe neonatal protein C deficiency: prevalence and thrombotic risk. J Pediatr. 1991 Nov; 119 (5): 793-8.","DOI":"10.1016\/S0022-3476(05)80305-1"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dahlb\u00e4ck B. Advances in understanding pathogenic mechanisms of thrombophilic disorders. Blood. 2008 Jul; 112 (1): 19-27.","DOI":"10.1182\/blood-2008-01-077909"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Sakata T, Okamoto A, Mannami T, et al. Protein C and antithrombin deficiency are important risk factors for deep vein thrombosis in Japanese. J Thromb Haemost. 2004 Mar; 2 (3): 528-30.","DOI":"10.1111\/j.1538-7836.2004.00603.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Dahlb\u00e4ck B. The protein C anticoagulant system: inherited defects as basis for venous thrombosis. Thromb Res. 1995 Jan; 77 (1): 1-43.","DOI":"10.1016\/0049-3848(94)00138-4"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Cooper PC, Pavlova A, Moore GW, et al. Recommendations for clinical laboratory testing for protein C deficiency, for the subcommittee on plasma coagulation inhibitors of the ISTH. J Thromb Haemost. 2020 Feb; 18 (2): 271-7.","DOI":"10.1111\/jth.14667"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Ichiyama M, Ohga S, Ochiai M, et al. Age-specific onset and distribution of the natural anticoagulant deficiency in pediatric thromboembolism. Pediatr Res. 2016 Jan; 79 (1-1): 81-6.","DOI":"10.1038\/pr.2015.180"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ohga S, Ishiguro A, Takahashi Y, et al. Protein C deficiency as the major cause of thrombophilias in childhood. Pediatr Int. 2013 Jun; 55 (3): 267-71.","DOI":"10.1111\/ped.12102"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Inoue H, Terachi SI, Uchiumi T, et al. The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene. Pediatr Blood Cancer. 2017 Jul; 64 (7): 10.1002\/pbc.26404.","DOI":"10.1002\/pbc.26404"},{"key":"11","unstructured":"11. Marlar RA, Montgomery RR, Broekmans AW. Diagnosis and treatment of homozygous protein C deficiency. Report of the Working Party on Homozygous Protein C deficiency of the Subcommittee on Protein C and Protein S, International Committee on Thrombosis and Haemostasis. J Pediatr. 1989 Apr; 114 (4 Pt 1): 528-34."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ohga S, Kang D, Kinjo T, et al. Paediatric presentation and outcome of congenital protein C deficiency in Japan. Haemophilia. 2013 May; 19 (3): 378-84.","DOI":"10.1111\/hae.12097"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Price VE, Ledingham DL, Kr\u00fcmpel A, et al. Diagnosis and management of neonatal purpura fulminans. Semin Fetal Neonatal Med. 2011 Dec; 16 (6): 318-22.","DOI":"10.1016\/j.siny.2011.07.009"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hattenbach LO, Beeg T, Kreuz W, et al. Ophthalmic manifestation of congenital protein C deficiency. J AAPOS. 1999 Jun; 3 (3): 188-90.","DOI":"10.1016\/S1091-8531(99)70066-2"}],"container-title":["Journal of Plastic and Reconstructive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jprs\/5\/3\/5_2025-0027\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:31:29Z","timestamp":1780111889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jprs\/5\/3\/5_2025-0027\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.53045\/jprs.2025-0027","relation":{},"ISSN":["2436-259X"],"issn-type":[{"value":"2436-259X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"article-number":"2025-0027"}}