{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:28:25Z","timestamp":1788449305103,"version":"build-2803163510"},"reference-count":18,"publisher":"Baishideng Publishing Group Inc.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Oncol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Herlyn-Werner-Wunderlich (HWW) syndrome is a rare M\u00fcllerian duct anomaly, characterized by a combination of urogenital abnormalities. The occurrence of primary cervico-vaginal carcinomas in patients with HWW syndrome is exceptionally rare, posing significant challenges for screening, early diagnosis, and effective management.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>We report a rare case of primary clear cell carcinoma of the vagina complicated in a 40-year-old woman with HWW syndrome. The patient presented with irregular vaginal bleeding for 4 years. On gynecological examination, an oblique vaginal septum was suspected. Surgical resection of the vaginal septum revealed a communicating fistula and a tumor on the left vagina and the left side of the septum, which was confirmed as clear cell carcinoma. One month later, she underwent a radical hysterectomy, vaginectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection. Due to significant side effects, she completed only one course of chemotherapy. A year later, lung metastasis was detected and continued to grow. A thoracoscopic wedge resection of the right upper lobe was performed 4 years after the initial surgery. We also conducted a systemic review of the literature on primary cervical or vaginal carcinoma in HWW syndrome to explore this rare entity.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Cervico-vaginal adenocarcinomas in patients with HWW syndrome are occult, and require early surgical intervention and regular imaging surveillance.<\/jats:p>","DOI":"10.5306\/wjco.v15.i10.1359","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T01:40:42Z","timestamp":1727574042000},"page":"1359-1365","source":"Crossref","is-referenced-by-count":3,"title":["Vaginal clear cell adenocarcinoma in Herlyn-Werner-Wunderlich syndrome: A case report"],"prefix":"10.5306","volume":"15","author":[{"given":"Xian-Gao","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12489"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.149208"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det081"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv048"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(16)39008-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2017.65640"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2690-y"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.09.009"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2017.12.024"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.7150\/jca.30486"},{"key":"B11","unstructured":"Zeeshan-ud-din, Ahsan A. Vaginal clear cell adenocarcinoma with associated M\u00fcllerian duct anomalies, renal agenesis and situs inversus: report of a case with no known in-utero exposure with diethyl stilboestrol. J Pak Med Assoc 2009; 59: 568-570"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01178.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13867"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13528"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197104222841604"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2012.05.004"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01136"}],"container-title":["World Journal of Clinical Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v15\/i10\/1359.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v15\/i10\/1359.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T01:41:20Z","timestamp":1727574080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v15\/i10\/1359.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":18,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.5306\/wjco.v15.i10.1359","relation":{},"ISSN":["2218-4333"],"issn-type":[{"value":"2218-4333","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,24]]}}}