{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:57:12Z","timestamp":1784030232449,"version":"3.55.0"},"reference-count":29,"publisher":"Baishideng Publishing Group Inc.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Oncol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Metastatic colorectal cancer (mCRC) treatment has been evolving and increasingly driven by tumor biology and gene expression analysis. Rechallenge with epidermal growth factor receptor (EGFR) inhibitors (anti-EGFR) represents a promising strategy for patients with RAS wild-type (RAS-wt) mCRC and circulating tumor DNA has emerged as a potential selection strategy. Herein, we report the case of a RAS-wt mCRC patient who had a successful response to cetuximab rechallenge.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>Our patient was diagnosed with stage IV RAS-wt, microsatellite-stable rectosigmoid junction adenocarcinoma. He was started on first-line treatment with FOLFIRI and cetuximab and achieved partial response, allowing for a left hepatectomy (R0), followed by post-operative chemotherapy and an anterior resection; progression-free survival (PFS) of 16 months was obtained. Due to hepatic and nodal relapse, second-line treatment with FOLFOX and bevacizumab was started with partial response; metastasectomy was performed (R0), achieving a PFS of 11 months. After a 15 months anti-EGFR-free interval, FOLFIRI and cetuximab were reintroduced upon disease progression, again with partial response and a PFS of 16 months. Following extensive hepatic relapse, cetuximab was reintroduced and a marked clinical and analytical improvement was seen, after only one cycle. RAS-wt status was confirmed on circulating tumor DNA. The patient\u2019s overall survival exceeded 5 years.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Our case provides real-world data to support cetuximab rechallenge in later lines of RAS-wt mCRC treatment.<\/jats:p>","DOI":"10.5306\/wjco.v15.i9.1232","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:45:57Z","timestamp":1724892357000},"page":"1232-1238","source":"Crossref","is-referenced-by-count":1,"title":["Successful cetuximab rechallenge in metastatic colorectal cancer: A case report"],"prefix":"10.5306","volume":"15","author":[{"given":"Alexandra","family":"Guedes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Cust\u00f3dio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Capela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"B1","unstructured":"World Health Organization.   Colorectal cancer. [cited 10 January 2024]. Available from: https:\/\/www.iarc.who.int\/cancer-type\/colorectal-cancer\/"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2018.81072"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21601"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15051473"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.12.019"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v16.i1.234"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0106"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01115"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/932932"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10040499"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305275"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60613-2"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.3797"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01140-9"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy281.095"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw235"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805019"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nm0715-827b"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.6116"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr623"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v11.i11.959"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.852583"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3133-8"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.5080"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy149.006"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.946850"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v14.i9.1654"}],"container-title":["World Journal of Clinical Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v15\/i9\/1232.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v15\/i9\/1232.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:47:10Z","timestamp":1724892430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v15\/i9\/1232.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":29,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.5306\/wjco.v15.i9.1232","relation":{},"ISSN":["2218-4333"],"issn-type":[{"value":"2218-4333","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,24]]}}}