{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:50:49Z","timestamp":1770472249986,"version":"3.49.0"},"reference-count":65,"publisher":"Baishideng Publishing Group Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Oncol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Dissection of the right paraesophageal lymph node (RPELN) in managing papillary thyroid carcinoma remains a contentious issue. This meta-analysis assesses previously established and novel risk factors associated with RPELN metastasis.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate previously established and novel risk factors associated with RPELN metastasis in patients with papillary thyroid carcinoma papillary thyroid carcinoma through a comprehensive meta-analysis.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>We searched MEDLINE (via  PubMed), ScienceDirect, Scopus and EMBASE up to December 2024. Studies were assessed using the Newcastle-Ottawa Scale. Statistical analysis was conducted with RevMan version 5.4, using the Q -test and I 2-test for heterogeneity. Sensitivity was evaluated with the leave-one-out method, and publication bias with the Egger regression test and funnel plot.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Of 2444 articles retrieved, 26 were included in our meta-analysis with 16427 patients. The RPELN metastasis rate was 12.98% [95% confidence interval (CI): 12.46%-13.50%]. The pooled results suggested that age &lt; 55 years [odds ratio (OR) = 1.71, 95%CI: 1.35-2.16, P  &lt; 0.00001], sex (OR = 0.60, 95%CI: 0.54-0.67, P  &lt; 0.00001), tumor size 1 cm (OR = 3.37, 95%CI: 2.69-4.21, P  &lt; 0.00001), multifocality (OR = 1.81, 95%CI: 1.49-2.20, P  &lt; 0.00001), capsular invasion (OR = 2.94, 95%CI: 2.05-4.20, P  &lt; 0.00001), vascular invasion (OR = 2.16, 95%CI: 1.56-2.99, P  &lt; 0.00001), extra-thyroid extension (OR = 3.30, 95%CI: 1.82-5.98, P  &lt; 0.0001), central lymph node metastasis (OR = 7.77, 95%CI: 4.73-12.76, P  &lt; 0.00001), lateral lymph node metastasis (OR = 6.94, 95%CI: 6.11-7.89, P  &lt; 0.00001), Hashimoto thyroiditis (OR = 0.79, 95%CI: 0.69-0.92, P  = 0.002), micro-calcifications (OR = 2.29, 95%CI: 1.20-4.37, P  = 0.01), and echogenicity (OR = 0.62, 95%CI: 0.40-0.98, P  = 0.04) should be considered with RPELN metastasis.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>The male &lt; 55, tumor size &gt; 1 cm, multifocality, capsular and vascular invasion, extrathyroidal extension, lymph node metastasis, and Hashimoto thyroiditis were significantly associated with RPELN metastasis and should be carefully assessed during dissection.<\/jats:p>","DOI":"10.5306\/wjco.v16.i11.110792","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:52:58Z","timestamp":1763693578000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological predictors of right para esophageal lymph node metastasis in papillary thyroid carcinoma: A systematic review and meta-analysis"],"prefix":"10.5306","volume":"16","author":[{"given":"Mirza Muhammad Hadeed","family":"Khawar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Hanan","family":"Abid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Bilal A","family":"Cheema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneeb","family":"Khawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneeba","family":"Shaukat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Huzaifa A","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneeb","family":"Saifullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimsha","family":"Noureen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza Aka","family":"Khail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Akram","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Abbas","family":"Khokhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.1743"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.20471\/acc.2020.59.s1.08"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.117691"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-1440"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071625"},{"key":"B6","unstructured":"Surveillance, Epidemiology, and End Results Program.   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