{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T04:10:52Z","timestamp":1750392652297,"version":"3.41.0"},"reference-count":49,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Oncol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>The prognosis for acute myeloid leukemia (AML) remains poor, underscoring the need for a deeper understanding of its underlying molecular mechanisms.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To assess the significance of SOX11  gene expression in the clinical features, response to treatment, and survival outcomes of adult patients with AML.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>This retrospective study enrolled 102 adults with AML. SOX11  gene expression in bone marrow samples was measured using real-time PCR. Data were correlated to the patients\u2019 clinical features, response to treatment, and survival rates.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>Increased SOX11  expression was significantly associated with the presence of the FLT3-ITD  mutation (P  &lt; 0.001), the FAB-M2 subtype (P  = 0.008), and cytogenetic abnormalities (P  = 0.011). However, no significant association was found between SOX11 expression and other clinical laboratory parameters, complete remission, disease-free survival, or overall survival.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>SOX11  expression may serve as a marker to identify specific subsets of AML patients who could benefit from intensive targeted chemotherapy.<\/jats:p>","DOI":"10.5306\/wjco.v16.i6.107271","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T01:05:19Z","timestamp":1750381519000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance of the transcription factor (SOX11) expression in the bone marrow of acute myeloid leukemia patients"],"prefix":"10.5306","volume":"16","author":[{"given":"Rania S","family":"Abdel Aziz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enas M","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhamid M","family":"Fouad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona S","family":"Abdellateif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Elfishawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000536152"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-024-01503-y"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-08000-0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.03.004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.11.001"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.06.016"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1008"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58970-z"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.15.6635-6644.2004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.09.026"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1177\/1758835919853449"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7437"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4149\/311_151029N552"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0718-3"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.008474"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3296-3"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-015-0219-7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0067"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-187"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3083-1"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.141"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1615"},{"key":"B23","unstructured":"Chang L, Yuan Z, Shi H, Bian Y, Guo R. miR-145 targets the SOX11 3'UTR to suppress endometrial cancer growth. 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