{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:00:51Z","timestamp":1780574451261,"version":"3.54.1"},"reference-count":19,"publisher":"Baishideng Publishing Group Inc.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Oncol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Multiple primary cancers refer to the presence of two or more distinct malignant tumors in a single individual, either simultaneously or sequentially. The synchronous occurrence of cholangiocarcinoma (CCA) and cervical squamous cell carcinoma (SCC) is extremely rare. This case highlights the diagnostic challenges and significance of a multidisciplinary team in managing complex malignancies involving both the hepatobiliary and gynecologic systems. The 8th edition of the American Joint Committee on Cancer staging system was as follows: T1aN0M0 intrahepatic CCA; the 2018 edition of the International Federation of Gynecology and Obstetrics staging system was stage IB1 cervical SCC.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>A 74-year-old postmenopausal woman (Karnofsky performance status = 80) presented with a one-day history of vaginal bleeding. Cross-sectional imaging (contrast-enhanced computed tomography, liver magnetic resonance imaging, and positron emission tomography\/computed tomography) first demonstrated a single 3-cm lesion in liver segment V and a hypermetabolic cervical mass. Subsequent ultrasound-guided liver biopsy confirmed CCA, whereas cervical biopsy revealed SCC. After multidisciplinary discussion, the patient underwent laparoscopic liver resection. Pelvic external-beam radiotherapy was delivered at 45 grays in 25 fractions (6-megavolt photons) over 5 weeks, followed by high-dose-rate 192Ir intracavitary brachytherapy, at 35 grays in 7 fractions (International Commission on Radiation Units and Measurements A-point). She received eight cycles of systemic therapy with lenvatinib, capecitabine, and camrelizumab. Over a 12-month follow-up, she remained disease-free with no signs of recurrence or metastasis.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Multidisciplinary management offers a promising strategy for treating synchronous complex malignancies with individualized treatment plans.<\/jats:p>","DOI":"10.5306\/wjco.v16.i9.109644","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:59:12Z","timestamp":1758589152000},"source":"Crossref","is-referenced-by-count":3,"title":["Synchronous cholangiocarcinoma and cervical squamous cell carcinoma managed <i>via<\/i> a multidisciplinary approach: A case report"],"prefix":"10.5306","volume":"16","author":[{"given":"Zhi-Jian","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Cong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-Teng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2017-000172"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i17.5764"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1174306"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-243563"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15082368"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1768632"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112607"},{"key":"B8","unstructured":"Scinicariello F, Sato T, Lee CS, Hsu HC, Chan TS, Tyring SK. Detection of human papillomavirus in primary hepatocellular carcinoma. Anticancer Res 1992; 763-766"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9730-z"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.11.014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.11.040"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02250-2"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004429"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1526103"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.21037\/cco-22-109"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.7150\/jca.65074"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1430551"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1308742"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2023-0133"}],"container-title":["World Journal of Clinical Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v16\/i9\/109644.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v16\/i9\/109644.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:59:37Z","timestamp":1758589177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2218-4333\/full\/v16\/i9\/109644.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":19,"journal-issue":{"issue":"9"},"alternative-id":["109644"],"URL":"https:\/\/doi.org\/10.5306\/wjco.v16.i9.109644","relation":{},"ISSN":["2218-4333"],"issn-type":[{"value":"2218-4333","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,24]]}}}