{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:45:10Z","timestamp":1771667110806,"version":"3.50.1"},"reference-count":16,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>An 18-month-old, intact female German shepherd dog was presented for evaluation of severe, frank hemorrhage from the vulva. A complete blood count, serum biochemical analysis, and urinalysis supported acute hemorrhage. Abdominal radiographs were unremarkable. Abdominal ultrasound demonstrated that the uterine body and cranial vaginal lumen were fluid-filled and contained hyperechoic, polypoid masses that were suspected to be blood clots. Exploratory laparotomy revealed a mildly enlarged uterus with a diffuse, cystic endometrium; significant amounts of blood and blood clots within the lumen; and several focal accumulations of yellow fluid presumed to be a purulent exudate. Histopathology confirmed severe, cystic, endometrial hyperplasia and pyometra complex.<\/jats:p>","DOI":"10.5326\/0380085","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:22:32Z","timestamp":1410783752000},"page":"85-89","source":"Crossref","is-referenced-by-count":14,"title":["Severe Hematometra in a Dog With Cystic Endometrial Hyperplasia\/Pyometra Complex"],"prefix":"10.5326","volume":"38","author":[{"given":"Mark T.","family":"Troxel","sequence":"first","affiliation":[{"name":"VCA South Shore Animal Hospital, 595 Columbian Street, South Weymouth, Massachusetts 02190"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelyn M.","family":"Cornetta","sequence":"additional","affiliation":[{"name":"VCA South Shore Animal Hospital, 595 Columbian Street, South Weymouth, Massachusetts 02190"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen F.","family":"Pastor","sequence":"additional","affiliation":[{"name":"VCA South Shore Animal Hospital, 595 Columbian Street, South Weymouth, Massachusetts 02190"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori E.","family":"Hartzband","sequence":"additional","affiliation":[{"name":"VCA South Shore Animal Hospital, 595 Columbian Street, South Weymouth, Massachusetts 02190"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Besancon","sequence":"additional","affiliation":[{"name":"VCA South Shore Animal Hospital, 595 Columbian Street, South Weymouth, Massachusetts 02190"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"R1","year":"1996","unstructured":"Feldman EC, Nelson RW. Cystic endometrial hyperplasia\/pyometra complex. In: Feldman EC, Nelson RW, eds. Canine and feline endocrinology and reproduction. Philadelphia: WB Saunders,\n          1996:605\u2013618."},{"key":"R2","series-title":"Sem Vet Med Surg","first-page":"21","volume":"10","year":"1995","unstructured":"Threlfall WR. Diagnosis and medical management of pyometra.\n          Sem Vet Med Surg\n          1995;10:21\u201329."},{"key":"R3","series-title":"Vet Rec","first-page":"659","volume":"143","year":"1998","unstructured":"Dhaliwal GK, Wray C, Noakes DE. Uterine bacterial flora and uterine lesions in bitches with cystic endometrial hyperplasia (pyometra).\n          Vet Rec\n          1998;143:659\u2013661."},{"key":"R4","series-title":"Sem Vet Med Surg","first-page":"7","volume":"9","year":"1994","unstructured":"Root CR, Spaulding KA. Diagnostic imaging in companion animal theriogenology.\n          Sem Vet Med Surg\n          1994;9:7\u201327."},{"key":"R5","series-title":"J Am Vet Med Assoc","first-page":"1557","volume":"189","year":"1986","unstructured":"Meyers-Wallen VN, Goldschmidt MH, Flickenger GL. Prostaglandin F2\u03b1 treatment of canine pyometra.\n          J Am Vet Med Assoc\n          1986;189:1557\u20131561."},{"key":"R6","series-title":"J Am Vet Med Assoc","first-page":"899","volume":"191","year":"1982","unstructured":"Nelson RW, Feldman EC, Stabenfeldt GH. Treatment of canine pyometra and endometritis with prostaglandin F2\u03b1.\n          J Am Vet Med Assoc\n          1982;191:899\u2013903."},{"key":"R7","series-title":"Therio","first-page":"11","volume":"4","year":"1975","unstructured":"Arbeiter VK. The use of progestins in the treatment of persistent uterine hemorrhage in the postpartum bitch and cow: a clinical report.\n          Therio\n          1975;4:11\u201313."},{"key":"R8","series-title":"J Reprod Fertil Suppl","first-page":"471","volume":"47","year":"1993","unstructured":"Dickie MB, Arbeiter VK. Diagnosis and therapy of subinvolution of placental sites in the bitch.\n          J Reprod Fertil Suppl\n          1993;47:471\u2013475."},{"key":"R9","series-title":"J Am Anim Hosp Assoc","first-page":"437","year":"1998","unstructured":"Padgett SL, Stokes JE, Tucker RL, et al. Hematometra secondary to anticoagulant rodenticide toxicity.\n          J Am Anim Hosp Assoc\n          1998:437\u2013439."},{"key":"R10","series-title":"Arq Bras Med Vet Zootoc","first-page":"13","volume":"46","year":"1994","unstructured":"Malm C, Ferreira HI, Nascimento EF, et al. Clinical and histopathological study of ovarian and uterine alterations of bitches under ovario-hysterectomy. 1-Granulosa cell tumors.\n          Arq Bras Med Vet Zootoc\n          1994;46:13\u201318."},{"key":"R11","series-title":"Vet Med","first-page":"734","volume":"92","year":"1997","unstructured":"Gotthelf LN. An unusual case of recurrent hematuria.\n          Vet Med\n          1997;92:734\u2013736."},{"key":"R12","series-title":"J Am Vet Med Assoc","first-page":"447","volume":"185","year":"1984","unstructured":"Wheeler SL, Weingand KW, Thrall MA, et al. Persistent uterine and vaginal hemorrhage in a beagle with factor VII deficiency.\n          J Am Vet Med Assoc\n          1984;185:447\u2013448."},{"key":"R13","series-title":"Indian Vet J","first-page":"879","volume":"68","year":"1991","unstructured":"Joshi BP, Humor A. Prepubertal metrorrhagia in bitches: a case study.\n          Indian Vet J\n          1991;68:879\u2013880."},{"key":"R14","series-title":"J Sm Anim Pract","first-page":"235","volume":"37","year":"1996","unstructured":"Arnold S, Hubler M, Hauser B, et al. Uterine serosal inclusion cysts in a bitch.\n          J Sm Anim Pract\n          1996;37:235\u2013237."},{"key":"R15","series-title":"Vet Med","first-page":"460","volume":"94","year":"1999","unstructured":"Couto CG. Managing thrombocytopenia in dogs and cats.\n          Vet Med\n          1999;94:460\u2013465."},{"key":"R16","series-title":"Comp Cont Ed","first-page":"13","volume":"14","year":"1992","unstructured":"Meyers KM, Wardhop KJ, Meinkoth J. Canine von Willebrand\u2019s disease: pathobiology, diagnosis, and short-term treatment.\n          Comp Cont Ed\n          1992;14:13\u201321."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/38\/1\/article-p85.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/38\/1\/85\/1330236\/0380085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/38\/1\/article-p85.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/38\/1\/article-p85.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:47:29Z","timestamp":1763740049000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/38\/1\/article-p85.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":16,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5326\/0380085","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}