{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:06:20Z","timestamp":1763741180033,"version":"3.45.0"},"reference-count":23,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n                    Echocardiographic studies from 50 dogs with congenital subaortic stenosis were examined. The degree of concentric, left-ventricular hypertrophy as assessed by M-mode measurement demonstrated a positive relationship (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05) to disease severity. However, the clinical utility of these measures is hindered by a large amount of individual variation (r\n                    <jats:sup>2<\/jats:sup>\n                    =0.243 to 0.473). Two-dimensional ultrasound was used to compare the cross-sectional area of the left-ventricular outflow tract to the cross-sectional area of the aortic root. The ratio of these two areas demonstrated a strong inverse relationship (\n                    <jats:italic>P<\/jats:italic>\n                    =0.001; r\n                    <jats:sup>2<\/jats:sup>\n                    =0.778) with disease severity. This ratio provides a method of estimating severity of disease by two-dimensional echocardiography.\n                  <\/jats:p>","DOI":"10.5326\/0380209","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:23:10Z","timestamp":1410783790000},"page":"209-215","source":"Crossref","is-referenced-by-count":17,"title":["Two-Dimensional and M-Mode Echocardiographic Predictors of Disease Severity in Dogs With Congenital Subaortic Stenosis"],"prefix":"10.5326","volume":"38","author":[{"given":"Mark A.","family":"Oyama","sequence":"first","affiliation":[{"name":"Department of Medicine and Epidemiology (Oyama, Thomas), College of Veterinary Medicine, University of California, Davis, California 95616"},{"name":"Cardiology Northwest (Oyama), 10629 Southwest Barbur Boulevard, Portland, Oregon 97219"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William P.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology (Oyama, Thomas), College of Veterinary Medicine, University of California, Davis, California 95616"},{"name":"Cardiology Northwest (Oyama), 10629 Southwest Barbur Boulevard, Portland, Oregon 97219"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"R1","series-title":"Am Heart J","first-page":"324","volume":"92","year":"1976","unstructured":"Pyle RL, Patterson DF, Chacko S. The genetics and pathology of discrete subaortic stenosis in the Newfoundland dog.\n          Am Heart J\n          1976;92:324\u2013334."},{"year":"1994","key":"R2","unstructured":"Weyman AE, Griffin BP. Left ventricular outflow tract: the aortic valve, aorta, and subvalvular outflow tract. In: Weyman AE, ed. Principles and practice of echocardiography. 2nd ed. Philadelphia: Lea & Febiger,\n          1994:498."},{"key":"R3","series-title":"Am J Vet Res","first-page":"192","volume":"55","year":"1994","unstructured":"Lehmkuhl LB, Bonagura JD. Comparison of transducer placement sites for Doppler echocardiography in dogs with subaortic stenosis.\n          Am J Vet Res\n          1994;55:192\u2013198."},{"key":"R4","series-title":"J Am Vet Med Assoc","first-page":"673","volume":"183","year":"1983","unstructured":"Wingfield WE, Boon JA, Miller CW. Echocardiographic assessment of congenital aortic stenosis in dogs.\n          J Am Vet Med Assoc\n          1983;183:673\u2013676."},{"key":"R5","series-title":"J Vet Intern Med","first-page":"423","volume":"8","year":"1994","unstructured":"Kienle RD, Thomas WP, Pion PD. The natural clinical history of canine congenital subaortic stenosis.\n          J Vet Intern Med\n          1994;8:423\u2013431."},{"key":"R6","series-title":"J Vet Intern Med","first-page":"164","volume":"10","year":"1996","unstructured":"Sisson D, Brown W. Pulsed wave Doppler blood flow velocities and transvalvular volume flow estimates in adult male hounds.\n          J Vet Intern Med\n          1996;10:164."},{"key":"R7","series-title":"Am J Cardiol","first-page":"450","volume":"57","year":"1986","unstructured":"Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings.\n          Am J Cardiol\n          1986;57:450\u2013458."},{"key":"R8","series-title":"Am J Cardiol","first-page":"946","volume":"51","year":"1983","unstructured":"Donner R, Carabello BA, Black I, Spann JF. Left ventricular wall stress in compensated aortic stenosis in children.\n          Am J Cardiol\n          1983;51:946\u2013951."},{"key":"R9","series-title":"Am Heart J","first-page":"202","volume":"103","year":"1982","unstructured":"Reichek N, Devereux RB. Reliable estimation of peak left ventricular systolic pressure by M-mode echographic-determined end-diastolic relative wall thickness: identification of severe valvular aortic stenosis in adult patients.\n          Am Heart J\n          1982;103:202\u2013203."},{"key":"R10","series-title":"Am J Cardiol","first-page":"896","volume":"53","year":"1984","unstructured":"Motro M, Schneeweiss A, Shem-Tov A, et al. Two-dimensional echocardiography in discrete subaortic stenosis.\n          Am J Cardiol\n          1984;53:896\u2013898."},{"key":"R11","series-title":"Circulation","first-page":"854","volume":"67","year":"1983","unstructured":"DePace NL, Ren JF, Iskandrian AS, Kotler MN, Hakki AH, Segal BL. Correlation of echocardiographic wall stress and left ventricular pressure and function in aortic stenosis.\n          Circulation\n          1983;67:854\u2013859."},{"key":"R12","series-title":"J Am Coll Cardiol","first-page":"1685","volume":"33","year":"1999","unstructured":"Schunkert H, Brockel U, Hengstenberg C, et al. Familial predisposition of left ventricular hypertrophy.\n          J Am Coll Cardiol\n          1999;33:1685\u20131691."},{"key":"R13","series-title":"Circulation","first-page":"1099","volume":"86","year":"1992","unstructured":"Carroll JD, Carroll EP, Feldman T, et al. Sex-associated differences in left ventricular function in aortic stenosis of the elderly.\n          Circulation\n          1992;86:1099\u20131107."},{"key":"R14","series-title":"Eur J Cardiothorac Surg","first-page":"24","volume":"15","year":"1999","unstructured":"Bech-Hanssen O, Wallentin I, Houltz E, et al. Gender differences in patients with severe aortic stenosis: impact on preoperative left ventricular geometry and function, as well as early postoperative morbidity and mortality.\n          Eur J Cardiothorac Surg\n          1999;15:24\u201330."},{"key":"R15","series-title":"Arzneimittelforschung","first-page":"612","volume":"41","year":"1991","unstructured":"Takemori E, Hasegawa Y, Katahira J, Nakao K, Inukai T. Effect of benazepril hydrochloride on cardiac hypertrophy in spontaneously hypertensive rats.\n          Arzneimittelforschung\n          1991;41:612\u2013615."},{"key":"R16","series-title":"J Mol Med","first-page":"867","volume":"75","year":"1997","unstructured":"Schunkert H. Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease.\n          J Mol Med\n          1997;75:867\u2013875."},{"key":"R17","series-title":"Curr Opin Cardiol","first-page":"347","volume":"12","year":"1997","unstructured":"Ruzicka M, Leenen FH. Update on local cardiac renin-angiotensin system.\n          Curr Opin Cardiol\n          1997;12:347\u2013353."},{"key":"R18","series-title":"Clin Cardiol","first-page":"711","volume":"15","year":"1992","unstructured":"Gilbert BW. ACE inhibitors and regression of left ventricular hypertrophy.\n          Clin Cardiol\n          1992;15:711\u2013714."},{"key":"R19","series-title":"J Am Coll Cardiol","first-page":"494","volume":"34","year":"1999","unstructured":"Karjalainen J, Kujala UM, Stolt A, et al. Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes.\n          J Am Coll Cardiol\n          1999;34:494\u2013499."},{"key":"R20","series-title":"Am J Cardiol","first-page":"1315","volume":"77","year":"1996","unstructured":"Gharavi AG, Lipkowitz MS, Diamond JA, et al. Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension.\n          Am J Cardiol\n          1996;77:1315\u20131319."},{"key":"R21","series-title":"J Heart Valve Dis","first-page":"S132","volume":"4","year":"1995","unstructured":"Carabello BA. The relationship of left ventricular geometry and hypertrophy to left ventricular function in valvular heart disease.\n          J Heart Valve Dis\n          1995;4 Suppl 2:S132\u2013S138."},{"key":"R22","series-title":"Cardiol","first-page":"291","volume":"81","year":"1992","unstructured":"Kannel WB, Cobb J. Left ventricular hypertrophy and mortality\u2014results from the Framingham study.\n          Cardiol\n          1992;81:291\u2013298."},{"key":"R23","series-title":"N Engl J Med","first-page":"1561","volume":"322","year":"1990","unstructured":"Levy D, Garrison RJ, Savage DD, et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study.\n          N Engl J Med\n          1990;322:1561\u20131566."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/38\/3\/article-p209.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/38\/3\/209\/1329110\/0380209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/38\/3\/article-p209.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/38\/3\/article-p209.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:47:02Z","timestamp":1763740022000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/38\/3\/article-p209.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":23,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5326\/0380209","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"type":"print","value":"0587-2871"},{"type":"electronic","value":"1547-3317"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}