{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:20:31Z","timestamp":1771946431753,"version":"3.50.1"},"reference-count":11,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>Five adult Samoyed dogs from two unrelated litters were diagnosed with diabetes mellitus. Two full-sibling male dogs (Family A) were raised in the same household. The other three dogs, two female and one male, were also full siblings (Family B) raised in different households. All five dogs developed polyuria and polydipsia and demonstrated fasting hyperglycemia and glucosuria. Diabetes mellitus was diagnosed in all five dogs and responded to appropriate therapy with insulin. The occurrence of insulin-dependent diabetes mellitus in multiple, closely related Samoyed dogs suggests a familial predisposition in this breed.<\/jats:p>","DOI":"10.5326\/0380235","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:23:10Z","timestamp":1410783790000},"page":"235-238","source":"Crossref","is-referenced-by-count":10,"title":["Familial Insulin-Dependent Diabetes Mellitus in Samoyed Dogs"],"prefix":"10.5326","volume":"38","author":[{"given":"Susan E.","family":"Kimmel","sequence":"first","affiliation":[{"name":"Sections of Medicine (Kimmel, Ward, Hess) and Medical Genetics (Henthorn), Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia R.","family":"Ward","sequence":"additional","affiliation":[{"name":"Sections of Medicine (Kimmel, Ward, Hess) and Medical Genetics (Henthorn), Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula S.","family":"Henthorn","sequence":"additional","affiliation":[{"name":"Sections of Medicine (Kimmel, Ward, Hess) and Medical Genetics (Henthorn), Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecka S.","family":"Hess","sequence":"additional","affiliation":[{"name":"Sections of Medicine (Kimmel, Ward, Hess) and Medical Genetics (Henthorn), Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"R1","series-title":"J Am Anim Hosp Assoc","first-page":"189","volume":"1","year":"1965","unstructured":"Anderson NV. Diseases of the canine pancreas.\n          J Am Anim Hosp Assoc\n          1965;1:189\u2013194."},{"key":"R2","series-title":"J Am Vet Med Assoc","first-page":"521","volume":"197","year":"1977","unstructured":"Ling GV, Lowenstein LJ, Pulley LT, Kaneko JJ. Diabetes mellitus in the dogs: a review of initial evaluation, immediate and long-term management and outcome.\n          J Am Vet Med Assoc\n          1977;197:521\u2013530."},{"key":"R3","series-title":"J Am Vet Med Assoc","first-page":"1414","volume":"216","year":"2000","unstructured":"Hess RS, Kass PH, Ward CR. Breed distribution of diabetes mellitus in dogs admitted to a tertiary care facility.\n          J Am Vet Med Assoc\n          2000;216:1414\u20131417."},{"key":"R4","series-title":"Am J Vet Res","first-page":"428","volume":"49","year":"1988","unstructured":"Kramer JW, Klaassen JK, Baskin DG, et al. Inheritance of diabetes mellitus in keeshond dogs.\n          Am J Vet Res\n          1988;49:428\u2013431."},{"key":"R5","series-title":"Am J Vet Res","first-page":"465","volume":"43","year":"1982","unstructured":"Marmor M, Willeberg P, Glickman LT, Priester WA, Cypess RH, Hurvitz AI. Epizootiologic patterns of diabetes mellitus in dogs.\n          Am J Vet Res\n          1982;43:465\u2013470."},{"key":"R6","series-title":"Brit Med J","first-page":"627","volume":"671","year":"1969","unstructured":"Gamble DR, Kinsley MJ, Fitzgerald MG, Bolton R, Taylor KW. Viral antibodies in diabetes mellitus.\n          Brit Med J\n          1969;671:627\u2013630."},{"key":"R7","series-title":"N Eng J Med","first-page":"1173","volume":"300","year":"1979","unstructured":"Yoon JW, Austin M, Onodera T, Notkins AL. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis.\n          N Eng J Med\n          1979;300:1173\u20131179."},{"key":"R8","series-title":"Diabetologia","first-page":"1235","volume":"40","year":"1997","unstructured":"Haverkos HW. Could the aetiology of IDDM be multifactorial?\n          Diabetologia\n          1997;40:1235\u20131240."},{"key":"R9","series-title":"Fed Proc","first-page":"1091","volume":"41","year":"1982","unstructured":"Williams MD, Padgett GA, Schall WD, et al. Etiology of diabetes mellitus in a colony of dogs (abstr).\n          Fed Proc\n          1982;41:1091."},{"key":"R10","series-title":"Endocrine J","first-page":"605","volume":"43","year":"1996","unstructured":"Ikegami H, Ogihara T. Genetics of insulin-dependent diabetes mellitus.\n          Endocrine J\n          1996;43:605\u2013613."},{"key":"R11","series-title":"Diabetes Metab","first-page":"291","volume":"22","year":"1996","unstructured":"Rotig A, Bonnefont J-P, Munnich A. Mitochondrial diabetes mellitus.\n          Diabetes Metab\n          1996;22:291\u2013298."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/38\/3\/article-p235.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/38\/3\/235\/1328998\/0380235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/38\/3\/article-p235.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/38\/3\/article-p235.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:47:25Z","timestamp":1763740045000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/38\/3\/article-p235.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":11,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5326\/0380235","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}