{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:45:28Z","timestamp":1775742328466,"version":"3.50.1"},"reference-count":9,"publisher":"American Animal Hospital Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>The purpose of this study was to determine if the presence of histopathologically tumor-free versus nontumor-free margins was prognostic for relapse or tumor-related death in dogs following surgical excision of single or multiple cutaneous mast cell tumors confined to the skin without evidence of metastasis to lymph nodes or other noncutaneous sites. Differences in tumor-related death or frequency of relapse between the two groups were not significant. Failure to achieve histopathological tumor-free margins frequently did not lead to local relapse. All tumor-related deaths occurred following local relapse. The lack of statistical support for an association between prognosis and histopathological tumor-free versus nontumor-free margins may be a result of small sample size.<\/jats:p>","DOI":"10.5326\/0380458","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:23:20Z","timestamp":1410783800000},"page":"458-466","source":"Crossref","is-referenced-by-count":78,"title":["Prognosis Following Surgical Excision of Canine Cutaneous Mast Cell Tumors With Histopathologically Tumor-Free Versus Nontumor-Free Margins: A Retrospective Study of 31 Cases"],"prefix":"10.5326","volume":"38","author":[{"given":"Gina M.","family":"Michels","sequence":"first","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Michels, Knapp, Bonney) and Veterinary Pathobiology (DeNicola, Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah W.","family":"Knapp","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Michels, Knapp, Bonney) and Veterinary Pathobiology (DeNicola, Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis B.","family":"DeNicola","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Michels, Knapp, Bonney) and Veterinary Pathobiology (DeNicola, Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nita","family":"Glickman","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Michels, Knapp, Bonney) and Veterinary Pathobiology (DeNicola, Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patty","family":"Bonney","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Michels, Knapp, Bonney) and Veterinary Pathobiology (DeNicola, Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"R1","series-title":"Sem Vet Med Surg","first-page":"72","volume":"1","year":"1984","unstructured":"Macy DW. Canine and feline mast cell tumors: biologic behavior, diagnosis, and therapy.\n          Sem Vet Med Surg\n          1984;1:72\u201383."},{"key":"R2","series-title":"J Sm Anim Pract","first-page":"27","volume":"14","year":"1973","unstructured":"Bostock DE. The prognosis following surgical removal of mastocytomas in dogs.\n          J Sm Anim Pract\n          1973;14:27\u201340."},{"key":"R3","series-title":"Vet Path","first-page":"469","volume":"21","year":"1984","unstructured":"Patnaik AK, Ehler WY, MacEwen EG. Canine cutaneous mast cell tumors: morphologic grading and survival time in 83 dogs.\n          Vet Path\n          1984;21:469\u2013474."},{"key":"R4","series-title":"Vet Path","first-page":"637","volume":"31","year":"1994","unstructured":"Simoes JPC, Schoning P, Butine M. Prognosis of canine mast cell tumors: a comparison of three methods.\n          Vet Path\n          1994;31:637\u2013647."},{"key":"R5","year":"1996","unstructured":"Vail DM. Mast cell tumors. In: Withrow SJ, MacEwen EG, eds. Small animal clinical oncology. Philadelphia: WB Saunders,\n          1996:192\u2013210."},{"key":"R6","series-title":"J Am Vet Med Assoc","first-page":"936","volume":"193","year":"1988","unstructured":"Turrel JM, Kitchell BE, Miller LM, Theon A. Prognostic factors for radiation treatment of mast cell tumor in 85 dogs.\n          J Am Vet Med Assoc\n          1988;193:936\u2013940."},{"key":"R7","series-title":"Br J Cancer","first-page":"915","volume":"59","year":"1989","unstructured":"Bostock DE, Crocker J, Harris K, Smith P. Nucleolar organiser regions as indicators of postsurgical prognosis in canine spontaneous mast cell tumours.\n          Br J Cancer\n          1989;59:915\u2013918."},{"key":"R8","series-title":"J Am Anim Hosp Assoc","first-page":"71","volume":"38","year":"2002","unstructured":"Weisse C, Shofer FS, Sorenmo K. Recurrence rates and sites for grade II canine cutaneous mast cell tumors following complete surgical excision.\n          J Am Anim Hosp Assoc\n          2002;38:71\u201373."},{"key":"R9","series-title":"Vet Radiol and Ultrasound","first-page":"57","volume":"39","year":"1998","unstructured":"LaDue T, Price GS, Dodge R, Page RL, Thrall DE. Radiation therapy for incompletely resected canine mast cell tumors.\n          Vet Radiol and Ultrasound\n          1998;39:57\u201362."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/38\/5\/article-p458.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/38\/5\/458\/1325428\/0380458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/38\/5\/article-p458.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/38\/5\/article-p458.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:48:09Z","timestamp":1763740089000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/38\/5\/article-p458.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":9,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.5326\/0380458","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}