{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:44:13Z","timestamp":1787031853508,"version":"build-2736575974"},"reference-count":16,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>A 5-year-old, castrated male mixed-breed dog was presented for paraparesis, ataxia, hyperesthesia, and thrombocytopenia of 5 months\u2019 duration and recurrent seizures during the preceding 2 weeks. Multifocal neurological, ophthalmological, pulmonary, and cardiac diseases were identified. Magnetic resonance imaging and cerebrospinal fluid analysis supported a tentative diagnosis of neoplastic or inflammatory disease. A computed tomography-guided biopsy provided both cytopathological and histopathological evidence of intravascular lymphoma. The disease progressed despite chemotherapy with prednisone, L-asparginase, and vincristine. Postmortem histopathological examinations suggested intravascular lymphoma in the central and peripheral nervous systems as well as in multiple other organ systems. This is the first description of an antemortem diagnosis and treatment of intravascular lymphoma involving the central nervous system of a dog.<\/jats:p>","DOI":"10.5326\/0390090","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:25:46Z","timestamp":1410783946000},"page":"90-96","source":"Crossref","is-referenced-by-count":25,"title":["Intravascular Lymphoma Involving the Central and Peripheral Nervous Systems in a Dog"],"prefix":"10.5326","volume":"39","author":[{"given":"William W.","family":"Bush","sequence":"first","affiliation":[{"name":"Departments of Clinical Studies (Bush, Kapatkin, Vite) and Pathobiology (McManus, Van Winkle), School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliene L.","family":"Throop","sequence":"additional","affiliation":[{"name":"Departments of Clinical Studies (Bush, Kapatkin, Vite) and Pathobiology (McManus, Van Winkle), School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"McManus","sequence":"additional","affiliation":[{"name":"Departments of Clinical Studies (Bush, Kapatkin, Vite) and Pathobiology (McManus, Van Winkle), School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Kapatkin","sequence":"additional","affiliation":[{"name":"Departments of Clinical Studies (Bush, Kapatkin, Vite) and Pathobiology (McManus, Van Winkle), School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Vite","sequence":"additional","affiliation":[{"name":"Departments of Clinical Studies (Bush, Kapatkin, Vite) and Pathobiology (McManus, Van Winkle), School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom J.","family":"Van Winkle","sequence":"additional","affiliation":[{"name":"Departments of Clinical Studies (Bush, Kapatkin, Vite) and Pathobiology (McManus, Van Winkle), School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"R1","year":"1995","unstructured":"Hawkins E. Aspiration pneumonia. In: Bonagura JD, Kirk RW, eds. Kirk\u2019s current veterinary therapy XII. Philadelphia: WB Saunders,\n          1995:915\u2013919."},{"key":"R2","series-title":"Cancer","first-page":"1738","volume":"73","year":"1994","unstructured":"Dermirer T, Dail DH, Aboulafia DM. Four varied cases of intravascular lymphomatosis and a literature review.\n          Cancer\n          1994;73:1738\u20131745."},{"key":"R3","year":"1995","unstructured":"Oglive G, Moore A. Lymphoma. In: Oglive G, Moore A, eds. Managing the veterinary cancer patient. Trenton: Vet Learning Sys,\n          1995: 228\u2013248."},{"key":"R4","series-title":"Vet Pathol","first-page":"204","volume":"33","year":"1996","unstructured":"Caniatti M, Roccabianca P, Scanziani E, Paltinieri S, Moore PF. 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A report of ten patients with central nervous system involvement and a review of the disease process.\n          Adv Exp Med Biol\n          1999;455:249\u2013265."},{"key":"R11","series-title":"J Neuroimaging","first-page":"116","volume":"10","year":"2000","unstructured":"Liow K, Asmar P, Liow M, et al. Intravascular lymphomatosis: contribution of cerebral MRI findings to diagnosis.\n          J Neuroimaging\n          2000;10:116\u2013118."},{"key":"R12","series-title":"J Am Vet Med Assoc","first-page":"918","volume":"204","year":"1994","unstructured":"Kilrain CG, Saik JE, Jeglum KA. Malignant angioendotheliomatosis with retinal detachments in a dog.\n          J Am Vet Med Assoc\n          1994;204:918\u2013921."},{"key":"R13","series-title":"South Med J","first-page":"672","volume":"91","year":"1998","unstructured":"Devlin T, Moll S, Hulette C, Morgenlander JC. Intravascular malignant lymphomatosis with neurologic presentation: factors facilitating antemortem diagnosis.\n          South Med J\n          1998;91:672\u2013676."},{"key":"R14","series-title":"Arch Neurol","first-page":"374","volume":"57","year":"2000","unstructured":"Baumann TP, Hurwitz N, Karamitopolou-Diamantis E, Probst A, Herrmann R, Steck AJ. Diagnosis and treatment of intravascular lymphomatosis.\n          Arch Neurol\n          2000;57:374\u2013377."},{"key":"R15","series-title":"J Neurol Neurosurg Psychiatry","first-page":"403","volume":"67","year":"1999","unstructured":"Nakahara T, Saito T, Muroi A, et al. Intravascular lymphomatosis presenting as an ascending cauda equina: conus medullaris syndrome: remission after biweekly CHOP therapy.\n          J Neurol Neurosurg Psychiatry\n          1999;67:403\u2013406."},{"key":"R16","series-title":"Ann Neurol","first-page":"357","volume":"35","year":"1994","unstructured":"Harris P, Sigman J, Jaeckle K. Intravascular malignant lymphomatosis: amelioration of neurological symptoms with plasmapheresis.\n          Ann Neurol\n          1994;35:357\u2013359."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/39\/1\/article-p90.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/39\/1\/90\/1329948\/0390090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/39\/1\/article-p90.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/39\/1\/article-p90.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:49:23Z","timestamp":1763740163000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/39\/1\/article-p90.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":16,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5326\/0390090","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}