{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:09:19Z","timestamp":1791058159880,"version":"4.1.0"},"reference-count":49,"publisher":"American Animal Hospital Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p>\n                    <jats:italic>Bartonella vinsonii<\/jats:italic>\n                    (\n                    <jats:italic>B. vinsonii<\/jats:italic>\n                    ) subspecies\n                    <jats:italic>berkhoffii<\/jats:italic>\n                    is a recently recognized cause of endocarditis, myocarditis, and granulomatous disease in dogs. In an effort to elucidate other potential disease manifestations, the case records of 24 dogs that were seroreactive to\n                    <jats:italic>B. vinsonii<\/jats:italic>\n                    (\n                    <jats:italic>berkhoffii<\/jats:italic>\n                    ) antigens were studied retrospectively. Diagnoses included immune-mediated hemolytic anemia, neutrophilic or granulomatous meningoencephalitis, neutrophilic polyarthritis, cutaneous vasculitis, and uveitis. Repeated\n                    <jats:italic>B. vinsonii<\/jats:italic>\n                    (\n                    <jats:italic>berkhoffii<\/jats:italic>\n                    ) antibody titers became negative after treatment. This study indicates that a diverse spectrum of disease manifestations and clinicopathological abnormalities can be detected in dogs that are seroreactive to\n                    <jats:italic>B. vinsonii<\/jats:italic>\n                    (\n                    <jats:italic>berkhoffii<\/jats:italic>\n                    ) antigens.\n                  <\/jats:p>","DOI":"10.5326\/0400092","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:15:04Z","timestamp":1410783304000},"page":"92-101","source":"Crossref","is-referenced-by-count":66,"title":["Clinicopathological Abnormalities and Treatment Response in 24 Dogs Seroreactive to Bartonella vinsonii (berkhoffii) Antigens"],"prefix":"10.5326","volume":"40","author":[{"given":"Edward B.","family":"Breitschwerdt","sequence":"first","affiliation":[{"name":"Departments of Clinical Sciences (Breitschwerdt, Blann, Mun\u0303ana, Davidson, Jackson) and Farm Animal Health and Resource Management (Stebbins), College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 and the Department of Small Animal Medicine and Surgery (Willard), Texas A&M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasandra R.","family":"Blann","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences (Breitschwerdt, Blann, Mun\u0303ana, Davidson, Jackson) and Farm Animal Health and Resource Management (Stebbins), College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 and the Department of Small Animal Medicine and Surgery (Willard), Texas A&M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Stebbins","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences (Breitschwerdt, Blann, Mun\u0303ana, Davidson, Jackson) and Farm Animal Health and Resource Management (Stebbins), College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 and the Department of Small Animal Medicine and Surgery (Willard), Texas A&M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen R.","family":"Mun\u0303ana","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences (Breitschwerdt, Blann, Mun\u0303ana, Davidson, Jackson) and Farm Animal Health and Resource Management (Stebbins), College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 and the Department of Small Animal Medicine and Surgery (Willard), Texas A&M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences (Breitschwerdt, Blann, Mun\u0303ana, Davidson, Jackson) and Farm Animal Health and Resource Management (Stebbins), College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 and the Department of Small Animal Medicine and Surgery (Willard), Texas A&M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary A.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences (Breitschwerdt, Blann, Mun\u0303ana, Davidson, Jackson) and Farm Animal Health and Resource Management (Stebbins), College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 and the Department of Small Animal Medicine and Surgery (Willard), Texas A&M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Willard","sequence":"additional","affiliation":[{"name":"Departments of Clinical Sciences (Breitschwerdt, Blann, Mun\u0303ana, Davidson, Jackson) and Farm Animal Health and Resource Management (Stebbins), College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 and the Department of Small Animal Medicine and Surgery (Willard), Texas A&M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"R1","series-title":"Microbes Infect","first-page":"1193","volume":"2","year":"2000","unstructured":"Karem KL, Paddock CD, Regnery RL. 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Isolation of a new subspecies, Bartonella vinsonii subsp. arupensis from a cattle rancher: identity with isolates found in conjunction with Borrelia burgdorferi and Babesia microti among naturally infected mice.\n          J Clin Micro\n          1999;37:2598\u20132601."},{"key":"R17","series-title":"J Clin Microbiol","first-page":"154","volume":"33","year":"1995","unstructured":"Breitschwerdt EB, Kordick DL, Malarkey DE, et al. Endocarditis in a dog due to infection with a novel Bartonella subspecies.\n          J Clin Microbiol\n          1995;33:154\u2013160."},{"key":"R18","series-title":"J Clin Microbiol","first-page":"3618","volume":"37","year":"1999","unstructured":"Breitschwerdt EB, Atkins CE, Brown TT, et al. Bartonella vinsonii subspecies berkhoffii and related members of the alpha subdivision of the Proteobacteria in dogs with cardiac arrhythmias, endocarditis, or myocarditis.\n          J Clin Microbiol\n          1999;37:3618\u20133626."},{"key":"R19","series-title":"J Vet Intern Med","first-page":"37","volume":"14","year":"2000","unstructured":"Pappalardo BL, Brown T, Gookin JL, et al. Granulomatous disease associated with Bartonella infection in 2 dogs.\n          J Vet Intern Med\n          2000;14:37\u201342."},{"key":"R20","series-title":"J Clin Microbiol","first-page":"2631","volume":"37","year":"1999","unstructured":"Kordick SK, Breitschwerdt ED, Hegarty BC, et al. Coinfection with multiple tick-borne pathogens in a walker hound kennel in North Carolina.\n          J Clin Microbiol\n          1999;37:2631\u20132638."},{"key":"R21","series-title":"J Clin Microbiol","first-page":"2645","volume":"36","year":"1998","unstructured":"Breitschwerdt EB, Hegarty BC, Hancock SI. Sequential evaluation of dogs naturally infected with Ehrlichia canis, Ehrlichia chaffeensis, Ehrlichia equi, Ehrlichia ewingii, or Bartonella vinsonii.\n          J Clin Microbiol\n          1998;36:2645\u20132651."},{"key":"R22","series-title":"Am J Vet Res","first-page":"467","volume":"58","year":"1997","unstructured":"Pappalardo BL, Correa MT, York CC, et al. Epidemiologic evaluation of the risk factors associated with exposure and seroreactivity to Bartonella vinsonii in dogs.\n          Am J Vet Res\n          1997;58:467\u2013471."},{"key":"R23","series-title":"Vet Parasitol","first-page":"133","volume":"74","year":"1998","unstructured":"Baneth G, Breitschwerdt EB, Hegarty BC, et al. A survey of tick-borne bacteria and protozoa in naturally exposed dogs from Israel.\n          Vet Parasitol\n          1998;74:133\u2013142."},{"key":"R24","series-title":"J Am Vet Med Assoc","first-page":"480","volume":"219","year":"2001","unstructured":"Honadel TE, Chomel BB, Yamamoto K, et al. Seroepidemiology of Bartonella vinsonii subsp. berkhoffii exposure among healthy dogs.\n          J Am Vet Med Assoc\n          2001;219:480\u2013484."},{"key":"R25","series-title":"J Am Vet Med Assoc","first-page":"1092","volume":"218","year":"2001","unstructured":"Hinrichsen VL, Whitworth UG, Breitschwerdt EB, et al. Assessing the association between the geographic distribution of deer ticks and seropositivity rates to various tick-transmitted disease organisms in dogs.\n          J Am Vet Med Assoc\n          2001;218:1092\u20131097."},{"key":"R26","series-title":"J Clin Microbiol","first-page":"4193","volume":"38","year":"2000","unstructured":"Chang C, Kasten RW, Chomel BB, et al. Coyotes (Canis latrans) as the reservoir for a human pathogenic Bartonella species: molecular epidemiology of Bartonella vinsonii subsp. berkhoffii infection in coyotes from central coastal California.\n          J Clin Microbiol\n          2000;38:4193\u20134200."},{"key":"R27","series-title":"Vet Immunol Immunopathol","first-page":"125","volume":"83","year":"2001","unstructured":"Pappalardo BL, Brown TT, Tompkins M, et al. Immunopathology of Bartonella vinsonii (berkhoffii) in experimentally infected dogs.\n          Vet Immunol Immunopathol\n          2001;83:125\u2013147."},{"key":"R28","series-title":"J Clin Microbiol","first-page":"2215","volume":"37","year":"1999","unstructured":"Schouls LM, Van De Pol I, Rijpkema SGT, et al. Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks.\n          J Clin Microbiol\n          1999;37:2215\u20132222."},{"key":"R29","series-title":"J Clin Microbiol","first-page":"1221","volume":"39","year":"2001","unstructured":"Chang CC, Chomel BB, Kasten RW, et al. Molecular evidence of Bartonella spp. in questing adult Ixodes pacificus ticks in California.\n          J Clin Microbiol\n          2001;39:1221\u20131226."},{"key":"R30","series-title":"Am J Vet Res","first-page":"815","volume":"26","year":"1965","unstructured":"Ewing SA, Buckner RG. Manifestations of babesiosis, ehrlichiosis and combined infections in the dog.\n          Am J Vet Res\n          1965;26:815\u2013828."},{"key":"R31","series-title":"J Am Vet Med Assoc","first-page":"465","volume":"186","year":"1985","unstructured":"Greene CE, Burgdorfer W, Cavagnolo R, et al. 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Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease.\n          J Am Vet Med Assoc\n          2003;222:47\u201351."},{"key":"R47","series-title":"Antimicrob Agents Chemoth","first-page":"2448","volume":"41","year":"1997","unstructured":"Kordick DL, Papich MG, Breitschwerdt EB. Efficacy of enrofloxacin or doxycycline for treatment of Bartonella henselae or Bartonella clarridgeiae infection in cats.\n          Antimicrob Agents Chemoth\n          1997;41:2448\u20132455."},{"key":"R48","series-title":"Antimicrob Agents Chemotherap","first-page":"2387","volume":"39","year":"1995","unstructured":"Maurin M, Gasquet S, Ducco C, et al. MICs of 28 antibiotic compounds for 14 Bartonella (formerly Rochalimaea) isolates.\n          Antimicrob Agents Chemotherap\n          1995;39:2387\u20132391."},{"key":"R49","series-title":"Antimicrob Agents and Chemotherapy","first-page":"1391","volume":"44","year":"2000","unstructured":"Rolain J-M, Maurin M, Bryskier A, et al. In vitro activities of telithromycin (HMR 3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis.\n          Antimicrob Agents and Chemotherapy\n          2000;44:1391\u20131393."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/40\/2\/article-p92.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/40\/2\/92\/1330385\/0400092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/40\/2\/article-p92.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/40\/2\/article-p92.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:50:34Z","timestamp":1763740234000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/40\/2\/article-p92.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":49,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5326\/0400092","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}