{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:48:48Z","timestamp":1769572128324,"version":"3.49.0"},"reference-count":15,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>A 10-week-old, male German shepherd dog was presented with a primary complaint of episodic ptyalism, dysphagia, vomiting, and mandibular salivary gland enlargement. An esophagram with fluoroscopy showed normal pharyngeal and esophageal function; however, upper gastrointestinal endoscopy and cervical ultrasonography revealed a focal circumferential thickening of the midcervical esophageal muscular wall, consistent with esophageal spasm. The puppy responded dramatically and completely to phenobarbital treatment. An unusual syndrome of phenobarbital-responsive hypersialosis was consistent with this dog\u2019s clinical presentation and the finding of apparent esophageal spasm. The pathogenesis of this syndrome is unclear, but it may represent a form of limbic epilepsy or peripheral autonomic dysfunction.<\/jats:p>","DOI":"10.5326\/0400230","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:15:04Z","timestamp":1410783304000},"page":"230-237","source":"Crossref","is-referenced-by-count":10,"title":["Phenobarbital-Responsive Ptyalism, Dysphagia, and Apparent Esophageal Spasm in a German Shepherd Puppy"],"prefix":"10.5326","volume":"40","author":[{"given":"Kristi J.","family":"Gibbon","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706-1102"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren A.","family":"Trepanier","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706-1102"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fern A.","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706-1102"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"R1","year":"2000","unstructured":"Hand MS, Thatcher CD, Remillard RL, et al. Small Animal Clinical Nutrition. 4th ed. Marcline: Wadsworth Publishing,\n          2000:3\u20136."},{"key":"R2","series-title":"J Small Anim Pract","first-page":"416","volume":"41","year":"2000","unstructured":"Stonehewer J, Mackin AJ, Tasker S, et al. Idiopathic phenobarbital-responsive hypersialosis in the dog: an unusual form of limbic epilepsy?\n          J Small Anim Pract\n          2000;41:416\u2013421."},{"key":"R3","series-title":"Vet Rec","first-page":"268","volume":"104","year":"1979","unstructured":"Kelly DF, Lucke VM, Lane JG. Salivary gland necrosis in dogs.\n          Vet Rec\n          1979;104:268."},{"key":"R4","series-title":"Can Vet J","first-page":"562","volume":"32","year":"1991","unstructured":"Mawby DI, Bauer MS, Lloyd-Bauer PM, et al. Vasculitis and necrosis of the mandibular salivary glands and chronic vomiting in a dog.\n          Can Vet J\n          1991;32:562\u2013564."},{"key":"R5","series-title":"New Zeal Vet J","first-page":"69","volume":"40","year":"1992","unstructured":"Cook MM, Guilford WG. Necrotizing sialoadenitis in a wire-haired fox terrier.\n          New Zeal Vet J\n          1992;40:69\u201372."},{"key":"R6","series-title":"J Small Anim Pract","first-page":"549","volume":"33","year":"1992","unstructured":"Chapman BL, Malik R. Phenobarbitone-responsive hypersialism in two dogs.\n          J Small Anim Pract\n          1992;33:549\u2013552."},{"key":"R7","series-title":"J Am Anim Hosp Assoc","first-page":"21","volume":"31","year":"1995","unstructured":"Brooks DG, Hottinger HA, Dunstan RW. Canine necrotizing sialometaplasia: a case report and review of the literature.\n          J Am Anim Hosp Assoc\n          1995;31:21\u201352."},{"key":"R8","series-title":"J Small Anim Pract","first-page":"121","volume":"39","year":"1998","unstructured":"Schroeder H, Berry WL. Salivary gland necrosis in dogs: a retrospective study of 19 cases.\n          J Small Anim Pract\n          1998;39:121\u2013125."},{"key":"R9","series-title":"J Am Vet Med Assoc","first-page":"872","volume":"216","year":"2000","unstructured":"Boydell P, Pike R, Crossley D, et al. Sialadenosis in dogs.\n          J Am Vet Med Assoc\n          2000;216:872\u2013874."},{"key":"R10","series-title":"Vet Path","first-page":"438","volume":"16","year":"1979","unstructured":"Kelly DF, Lucke VM, Lane JG, et al. Histology of salivary gland necrosis in the dog.\n          Vet Path\n          1979;16:438\u2013443."},{"key":"R11","year":"1986","unstructured":"Seifert G, Miehlke A, Haubrich J, et al. Diseases of the Salivary Glands. New York: Thieme Inc.,\n          1986:78\u201384."},{"key":"R12","series-title":"Arch Toxicol","first-page":"394","volume":"60","year":"1987","unstructured":"Holzer P, Beubler E, Dirnhofer R. Barbiturate poisoning and gastrointestinal propulsion.\n          Arch Toxicol\n          1987;60:394\u2013396."},{"key":"R13","series-title":"Dig Dis Sci","first-page":"83","volume":"34","year":"1989","unstructured":"Anderson KO, Dalton CB, Bradley LA, et al. Stress induced alterations of esophageal pressures in healthy volunteers and noncardiac chest pain patients.\n          Dig Dis Sci\n          1989;34:83\u201391."},{"key":"R14","series-title":"Lancet","first-page":"823","volume":"358","year":"2001","unstructured":"Richter JE. Oesophageal motility disorders.\n          Lancet\n          2001;358:823\u2013828."},{"key":"R15","series-title":"J Am Vet Med Assoc","first-page":"37","volume":"15","year":"1979","unstructured":"Breitschwert EB, Breazile JE, Broadhurst JJ. Clinical and electroencephalographic findings associated with ten cases of suspected limbic epilepsy in the dog.\n          J Am Vet Med Assoc\n          1979;15:37\u201350."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/40\/3\/article-p230.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/40\/3\/230\/1329736\/0400230.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/40\/3\/article-p230.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/40\/3\/article-p230.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:51:09Z","timestamp":1763740269000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/40\/3\/article-p230.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":15,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5326\/0400230","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}