{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:15:13Z","timestamp":1790986513746,"version":"4.1.0"},"reference-count":20,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>A 6-year-old, male Labrador retriever was presented for lameness of the right forelimb. The lameness occurred 5 years after the dog was surgically treated for osteochondritis dissecans (OCD) of the caudal right humeral head. Radiographs revealed an expansile, osteolytic lesion occupying the entire caudal half of the right humeral head, and biopsy confirmed the diagnosis of osteosarcoma. Forelimb amputation was performed. Histopathology of the lesion and associated articular cartilage revealed neoplastic osteoblasts extensively infiltrating the marrow space adjacent to scar tissue associated with the previous OCD lesion. This is the first report of an epiphyseal osteosarcoma in the area of a previous OCD lesion in a dog.<\/jats:p>","DOI":"10.5326\/0400246","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:15:04Z","timestamp":1410783304000},"page":"246-249","source":"Crossref","is-referenced-by-count":9,"title":["Osteosarcoma of the Humeral Head Associated With Osteochondritis Dissecans in a Dog"],"prefix":"10.5326","volume":"40","author":[{"given":"Bradford J.","family":"Holmberg","sequence":"first","affiliation":[{"name":"Departments of Small Animal Clinical Sciences (Holmberg, Farese) and Pathobiology (Taylor, Uhl), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Farese","sequence":"additional","affiliation":[{"name":"Departments of Small Animal Clinical Sciences (Holmberg, Farese) and Pathobiology (Taylor, Uhl), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Taylor","sequence":"additional","affiliation":[{"name":"Departments of Small Animal Clinical Sciences (Holmberg, Farese) and Pathobiology (Taylor, Uhl), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Uhl","sequence":"additional","affiliation":[{"name":"Departments of Small Animal Clinical Sciences (Holmberg, Farese) and Pathobiology (Taylor, Uhl), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"R1","series-title":"J Natl Cancer Inst","first-page":"307","volume":"40","year":"1968","unstructured":"Dorn CR, Taylor DON, Schneider R, et al. 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Osteosarcoma eight years after total hip arthroplasty.\n          Vet Surg\n          1996;25:70\u201374."},{"key":"R14","series-title":"J Bone Joint Surg Am","first-page":"1849","volume":"12","year":"1997","unstructured":"Bahk WJ, Brien EW, Mirra JM. Osteosarcoma associated with osteochondritis dissecans.\n          J Bone Joint Surg Am\n          1997;12:1849\u20131853."},{"key":"R15","series-title":"Vet Clin North Am Small Anim Pract","first-page":"17","volume":"28","year":"1998","unstructured":"Ekman S, Carlson CS. The pathophysiology of osteochondrosis.\n          Vet Clin North Am Small Anim Pract\n          1998;28:17\u201332."},{"key":"R16","year":"1972","unstructured":"Jaffe HL. Certain disorders of individual epiphyses, apophyses, and epiphysoid bones. In: Jaffe HL, ed. Metabolic, Degenerative, and Inflammatory Diseases of Bones and Joints. 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