{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:13:42Z","timestamp":1792199622412,"version":"4.4.0"},"reference-count":57,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>A 6-year-old, spayed female rottweiler was presented for facial enlargement from swelling of the maxilla and mandible. The dog was fed a homemade diet deficient in calcium and vitamin D, suggesting that rubber jaw syndrome was a secondary nutritional disorder. Radiographic and tomodensitometric examinations revealed diffuse bone resorption in the skull. The plasma parathormone concentration was high, and serum 25-hydroxycholecalciferol concentration was low. Based on these findings, nutritional calcium and vitamin D deficiency associated with secondary hyperparathyroidism was diagnosed. Dietary correction resulted in clinical and biological improvement, with an increase in skull mineralization.<\/jats:p>","DOI":"10.5326\/0430052","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:04:42Z","timestamp":1410782682000},"page":"52-60","source":"Crossref","is-referenced-by-count":36,"title":["Unusual Case of Osteopenia Associated With Nutritional Calcium and Vitamin D Deficiency in an Adult Dog"],"prefix":"10.5326","volume":"43","author":[{"given":"Pauline","family":"de Fornel-Thibaud","sequence":"first","affiliation":[{"name":"Internal Medicine Unit (de Fornel-Thibaud, Escoffier-Chateau, Rosenberg), the Nutrition Unit (Blanchard), and the Radiology Unit (Begon), National Veterinary School of Alfort, Maisons-Alfort, France; the"},{"name":"Veterinary Anticancer Center (Segond, Delisle), Maisons-Alfort, France; and the"},{"name":"Vet France Laboratory (Guetta), Parc d\u2019activite\u0301 du Val de Seine 17, alle\u0301e JB Preux, BP 18 Alfortville, 94141 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u0301raldine","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit (de Fornel-Thibaud, Escoffier-Chateau, Rosenberg), the Nutrition Unit (Blanchard), and the Radiology Unit (Begon), National Veterinary School of Alfort, Maisons-Alfort, France; the"},{"name":"Veterinary Anticancer Center (Segond, Delisle), Maisons-Alfort, France; and the"},{"name":"Vet France Laboratory (Guetta), Parc d\u2019activite\u0301 du Val de Seine 17, alle\u0301e JB Preux, BP 18 Alfortville, 94141 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Escoffier-Chateau","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit (de Fornel-Thibaud, Escoffier-Chateau, Rosenberg), the Nutrition Unit (Blanchard), and the Radiology Unit (Begon), National Veterinary School of Alfort, Maisons-Alfort, France; the"},{"name":"Veterinary Anticancer Center (Segond, Delisle), Maisons-Alfort, France; and the"},{"name":"Vet France Laboratory (Guetta), Parc d\u2019activite\u0301 du Val de Seine 17, alle\u0301e JB Preux, BP 18 Alfortville, 94141 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Segond","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit (de Fornel-Thibaud, Escoffier-Chateau, Rosenberg), the Nutrition Unit (Blanchard), and the Radiology Unit (Begon), National Veterinary School of Alfort, Maisons-Alfort, France; the"},{"name":"Veterinary Anticancer Center (Segond, Delisle), Maisons-Alfort, France; and the"},{"name":"Vet France Laboratory (Guetta), Parc d\u2019activite\u0301 du Val de Seine 17, alle\u0301e JB Preux, BP 18 Alfortville, 94141 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Guetta","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit (de Fornel-Thibaud, Escoffier-Chateau, Rosenberg), the Nutrition Unit (Blanchard), and the Radiology Unit (Begon), National Veterinary School of Alfort, Maisons-Alfort, France; the"},{"name":"Veterinary Anticancer Center (Segond, Delisle), Maisons-Alfort, France; and the"},{"name":"Vet France Laboratory (Guetta), Parc d\u2019activite\u0301 du Val de Seine 17, alle\u0301e JB Preux, BP 18 Alfortville, 94141 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Begon","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit (de Fornel-Thibaud, Escoffier-Chateau, Rosenberg), the Nutrition Unit (Blanchard), and the Radiology Unit (Begon), National Veterinary School of Alfort, Maisons-Alfort, France; the"},{"name":"Veterinary Anticancer Center (Segond, Delisle), Maisons-Alfort, France; and the"},{"name":"Vet France Laboratory (Guetta), Parc d\u2019activite\u0301 du Val de Seine 17, alle\u0301e JB Preux, BP 18 Alfortville, 94141 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327oise","family":"Delisle","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit (de Fornel-Thibaud, Escoffier-Chateau, Rosenberg), the Nutrition Unit (Blanchard), and the Radiology Unit (Begon), National Veterinary School of Alfort, Maisons-Alfort, France; the"},{"name":"Veterinary Anticancer Center (Segond, Delisle), Maisons-Alfort, France; and the"},{"name":"Vet France Laboratory (Guetta), Parc d\u2019activite\u0301 du Val de Seine 17, alle\u0301e JB Preux, BP 18 Alfortville, 94141 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit (de Fornel-Thibaud, Escoffier-Chateau, Rosenberg), the Nutrition Unit (Blanchard), and the Radiology Unit (Begon), National Veterinary School of Alfort, Maisons-Alfort, France; 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Calcium disorders. In: Reed SM, Bayly WM, Sellon DC, eds. Equine Internal Medicine. 2nd ed. St. Louis: Saunders,\n          2004:1295\u20131327."},{"key":"R48","year":"2000","unstructured":"Kealy JK, McAllister H. The skull and vertebral column. In: Kealy JK, McAllister H, eds. Diagnostic Radiology and Ultrasonography of the Dog and the Cat. 3rd ed. Philadelphia: WB Saunders,\n          2000: 339\u2013411."},{"key":"R49","series-title":"J Am Vet Med Assoc","first-page":"703","volume":"217","year":"2000","unstructured":"Kimmel SE, Waddell LS, Michel KE. Hypomagnesemia and hypocalcemia associated with protein-losing enteropathy in Yorkshire terriers: five cases (1992\u20131998).\n          J Am Vet Med Assoc\n          2000;217:703\u2013706."},{"key":"R50","series-title":"J Small Anim Pract","first-page":"345","volume":"46","year":"2005","unstructured":"Mellanby RJ, Mellor PJ, Roulois A, et al. Hypocalcemia associated with low serum vitamin D metabolite concentrations in two dogs with protein-losing enteropathies.\n          J Small Anim Pract\n          2005;46:345\u2013351."},{"key":"R51","series-title":"J Nucl Med","first-page":"117","volume":"44","year":"2003","unstructured":"Piert M, Zittel TT, Jahn M, et al. Increased sensitivity in detection of a porcine high-turnover osteopenia after total gastrectomy by dynamic 18F-fluoride ion PET and quantitative CT.\n          J Nucl Med\n          2003;44:117\u2013124."},{"key":"R52","series-title":"Clin Orthop","first-page":"105","volume":"175","year":"1983","unstructured":"Cook SD, Skinner HB, Haddad RJ. A quantitative histologic study of osteoporosis produced by nutritional secondary hyperparathyroidism in dogs.\n          Clin Orthop\n          1983;175:105\u2013120."},{"key":"R53","series-title":"J Nutr","first-page":"631","volume":"100","year":"1970","unstructured":"Henrikson PA, Lutwak L, Krook L, et al. 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Effect of nutritional hyperparathyroidism on experimental periodontitis in the dog.\n          Scand J Dent Res\n          1973;81:155\u2013162."},{"key":"R57","series-title":"Intern Med","first-page":"394","volume":"39","year":"2000","unstructured":"Kikuchi H, Ujiie S, Kanamaru R. Osteomalacia that became symptomatic 13 years after a total gastrectomy.\n          Intern Med\n          2000;39:394\u2013396."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/43\/1\/article-p52.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/43\/1\/52\/1331111\/0430052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/43\/1\/article-p52.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/43\/1\/article-p52.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:54:00Z","timestamp":1763740440000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/43\/1\/article-p52.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":57,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5326\/0430052","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}