{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:45:51Z","timestamp":1774017951115,"version":"3.50.1"},"reference-count":22,"publisher":"American Animal Hospital Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>A 5-year-old, spayed female cat was referred because of a mass in the cranial mediastinum noted on thoracic radiographs. A thymoma was diagnosed following ultrasound and biopsy of the mass. Treatment was initiated with coarse-fraction radiation therapy using external-beam therapy (four fractions of 5 Gy). The mass responded, but granulocytopenia developed. Bone marrow examination showed a myeloid to erythroid ratio of approximately 1:1, with a left shift within the myeloid line. These findings, as well as the lack of toxic changes within the peripheral blood neutrophils, suggested immune-mediated destruction of peripheral granulocytes. Immune suppression with prednisone and cyclosporine was instituted. After 7 weeks, the neutrophil count returned to normal. The tumor was removed, and cyclosporine was reduced and eventually discontinued 3 weeks postsurgery.<\/jats:p>","DOI":"10.5326\/0440210","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:05:55Z","timestamp":1410782755000},"page":"210-217","source":"Crossref","is-referenced-by-count":14,"title":["Granulocytopenia Associated With Thymoma in a Domestic Shorthaired Cat"],"prefix":"10.5326","volume":"44","author":[{"given":"Janean L.","family":"Fidel","sequence":"first","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Fidel, Pargass, Holmes) and Veterinary Microbiology and Pathology (Dark), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indira S.","family":"Pargass","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Fidel, Pargass, Holmes) and Veterinary Microbiology and Pathology (Dark), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Dark","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Fidel, Pargass, Holmes) and Veterinary Microbiology and Pathology (Dark), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon P.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Clinical Sciences (Fidel, Pargass, Holmes) and Veterinary Microbiology and Pathology (Dark), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"R1","year":"2002","unstructured":"Morrison WB. 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Half-body radiotherapy in the treatment of canine lymphoma.\n          J Vet Intern Med\n          1989;3:102\u2013108."},{"key":"R14","series-title":"J Vet Intern Med","first-page":"1398","volume":"20","year":"2006","unstructured":"Axiak SM, Carreras JK, Hahn KA, et al. Hematologic changes associated with half-body irradiation in dogs with lymphoma.\n          J Vet Intern Med\n          2006;20:1398\u20131401."},{"key":"R15","series-title":"J Am Anim Hosp Assoc","first-page":"131","volume":"37","year":"2001","unstructured":"Brown MR, Rogers KS. Neutropenia in dogs and cats: a retrospective study of 261 cases.\n          J Am Anim Hosp Assoc\n          2001;37:131\u2013139."},{"key":"R16","series-title":"Am J Vet Res","first-page":"1809","volume":"46","year":"1985","unstructured":"Chickering WR, Prasse KW, Dawe DL. 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