{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:02:37Z","timestamp":1772326957964,"version":"3.50.1"},"reference-count":28,"publisher":"American Animal Hospital Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>\n                    The purpose of this study was to describe the clinical and gross pathological findings, treatment, and outcome in three dogs receiving deracoxib that developed proximal duodenal perforation and subsequent septic peritonitis. Clinical findings were acute vomiting and anorexia following initiation of deracoxib therapy. Deracoxib dosages ranged from 2 to 3 mg\/kg per os\n                    <jats:italic>q<\/jats:italic>\n                    24 hours. In each dog, exploratory laparotomy revealed duodenal perforations approximately 1 cm orad to the major duodenal papilla. Two out of three dogs survived following exploratory laparotomy. Two of three dogs in the present case series received the approved deracoxib dosage. Dogs receiving deracoxib, even at labeled dosages, should be monitored judiciously for signs of gastrointestinal disease.\n                  <\/jats:p>","DOI":"10.5326\/0460255","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:10:48Z","timestamp":1410783048000},"page":"255-258","source":"Crossref","is-referenced-by-count":31,"title":["Proximal Duodenal Perforation in Three Dogs Following Deracoxib Administration"],"prefix":"10.5326","volume":"46","author":[{"given":"J. Brad","family":"Case","sequence":"first","affiliation":[{"name":"Department of Surgery, Flatiron Veterinary Specialists, 230 South Main Street, Longmont, Colorado 80501"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Fick","sequence":"additional","affiliation":[{"name":"Department of Surgery, Flatiron Veterinary Specialists, 230 South Main Street, Longmont, Colorado 80501"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew B.","family":"Rooney","sequence":"additional","affiliation":[{"name":"Department of Surgery, Flatiron Veterinary Specialists, 230 South Main Street, Longmont, Colorado 80501"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"R1","year":"2002","unstructured":"Budsberg SC. Nonsteroidal anti-inflammatory drugs. In: Gaynor JS, Muir WW, eds. Handbook of Veterinary Pain Management. Philadelphia: Mosby Inc.,\n          2002:184\u2013198."},{"key":"R2","series-title":"Nat New Biol","first-page":"232","volume":"231","year":"1971","unstructured":"Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.\n          Nat New Biol\n          1971;231:232\u2013235."},{"key":"R3","series-title":"Surgery","first-page":"389","volume":"103","year":"1988","unstructured":"Miller TA. Gastroduodenal mucosal defense: factors responsible for the ability of the stomach and duodenum to resist injury.\n          Surgery\n          1988;103:389\u2013397."},{"key":"R4","series-title":"Ann Surg","first-page":"399","volume":"205","year":"1987","unstructured":"Gana TJ. Focal gastric mucosal blood flow in aspirin-induced ulceration.\n          Ann Surg\n          1987;205:399\u2013403."},{"key":"R5","series-title":"J Am Vet Med Assoc","first-page":"475","volume":"201","year":"1992","unstructured":"Jones RD, Baynes RE, Nimitz CT. 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Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, keto-profen, and meloxicam in dogs.\n          Am J Vet Res\n          2007;68:258\u2013264."},{"key":"R9","series-title":"J Am Vet Med Assoc","first-page":"1112","volume":"227","year":"2005","unstructured":"Lascelles BD, Blikslager AT, Fox SM, et al. Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002\u20132003).\n          J Am Vet Med Assoc\n          2005;227:1112\u20131117."},{"key":"R10","series-title":"J Vet Intern Med","first-page":"238","volume":"3","year":"1989","unstructured":"Stanton ME, Bright RM. Gastroduodenal ulceration in dogs. Retrospective study of 43 cases and literature review.\n          J Vet Intern Med\n          1989;3:238\u2013244."},{"key":"R11","series-title":"J Am Anim Hosp Assoc","first-page":"176","volume":"38","year":"2002","unstructured":"Hinton LE, McLoughlin MA, Johnson SE, et al. Spontaneous gastro-duodenal perforation in 16 dogs and seven cats (1982\u20131999).\n          J Am Anim Hosp Assoc\n          2002;38:176\u2013187."},{"key":"R12","series-title":"Br J Clin Pharmac","first-page":"127","volume":"29","year":"1990","unstructured":"Schneider HT, Nuernberg B, Dietzel K, et al. Biliary elimination of non-steroidal anti-inflammatory drugs in patients.\n          Br J Clin Pharmac\n          1990;29:127\u2013131."},{"key":"R13","series-title":"Pharmacology & Therapeutics","first-page":"649","volume":"112","year":"2006","unstructured":"Treinen-Molsen M, Kanz MF. Intestinal tract injury by drugs: importance of metabolite delivery by yellow bile road.\n          Pharmacology & Therapeutics\n          2006;112:649\u2013667."},{"key":"R14","series-title":"Gastroenterology","first-page":"1476","volume":"115","year":"1998","unstructured":"Seitz S, Boelsterli UA. 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