{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:20:52Z","timestamp":1770747652405,"version":"3.49.0"},"reference-count":34,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Animal Hospital Association"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>\n                    <jats:italic>Anaplasma<\/jats:italic>\n                    (\n                    <jats:italic>A.<\/jats:italic>\n                    )\n                    <jats:italic>phagocytophilum<\/jats:italic>\n                    , the etiological agent of canine granulocytic anaplasmosis, is capable of inciting moderate to severe clinical disease in a variety of mammals and is endemic in the upper midwest. The purpose of this study was fourfold: to describe the range of clinical signs in dogs seropositive to\n                    <jats:italic>A. phagocytophilum<\/jats:italic>\n                    ; to examine the prevalence of immune-mediated hemolytic anemia (IMHA) in this population; to evaluate whether specific clinical signs were associated with coexposure to\n                    <jats:italic>Borrelia<\/jats:italic>\n                    (\n                    <jats:italic>B.<\/jats:italic>\n                    )\n                    <jats:italic>burgdorferi<\/jats:italic>\n                    in actively infected dogs; and to determine whether clinical response to doxycycline was complete in treated dogs. Medical records of dogs seropositive for\n                    <jats:italic>A. phagocytophilum<\/jats:italic>\n                    were reviewed retrospectively. Peripheral blood smears were also reviewed retrospectively for granulocytic\n                    <jats:italic>Anaplasma<\/jats:italic>\n                    morulae. Lethargy (81%), inappetence (58%), and lameness (50%) were the most common clinical signs, followed by fever (46%). Thrombocytopenia was the most common laboratory abnormality, and IMHA was diagnosed in three dogs. Dogs that were thrombocytopenic and had antibodies to both\n                    <jats:italic>A. phagocytophilum<\/jats:italic>\n                    and\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    had a median platelet count of 51,000\/\u03bcL (range 20,000 to 171,000\/\u03bcL), which was significantly lower than the count in dogs with antibodies only to\n                    <jats:italic>A. phagocytophilum<\/jats:italic>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    =0.04). Some dogs had an apparent relapse of clinical signs after an appropriate course of doxycycline. Testing for\n                    <jats:italic>A. phagocytophilum<\/jats:italic>\n                    by polymerase chain reaction, serum antibody assays, and\/or blood smear evaluation should be considered in dogs with IMHA, cough, or epistaxis and that reside in\n                    <jats:italic>A. phagocytophilum<\/jats:italic>\n                    -endemic areas. If moderate to severe thrombocytopenia is present, testing for concurrent\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    infection may be warranted.\n                  <\/jats:p>","DOI":"10.5326\/0460405","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:21:20Z","timestamp":1410783680000},"page":"405-412","source":"Crossref","is-referenced-by-count":25,"title":["Clinical Presentation of 26 Anaplasma phagocytophilum-Seropositive Dogs Residing in an Endemic Area"],"prefix":"10.5326","volume":"46","author":[{"given":"Allison Wistrand","family":"Mazepa","sequence":"first","affiliation":[{"name":"Departments of Medical Sciences (Mazepa, Trepanier) and Pathobiological Sciences (Young), School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, Wisconsin 53706-1102 and the"},{"name":"Section of Small Animal Internal Medicine (Kidd), College of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, California 91766"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Benjamin","family":"Kidd","sequence":"additional","affiliation":[{"name":"Departments of Medical Sciences (Mazepa, Trepanier) and Pathobiological Sciences (Young), School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, Wisconsin 53706-1102 and the"},{"name":"Section of Small Animal Internal Medicine (Kidd), College of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, California 91766"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Young","sequence":"additional","affiliation":[{"name":"Departments of Medical Sciences (Mazepa, Trepanier) and Pathobiological Sciences (Young), School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, Wisconsin 53706-1102 and the"},{"name":"Section of Small Animal Internal Medicine (Kidd), College of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, California 91766"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren A.","family":"Trepanier","sequence":"additional","affiliation":[{"name":"Departments of Medical Sciences (Mazepa, Trepanier) and Pathobiological Sciences (Young), School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, Wisconsin 53706-1102 and the"},{"name":"Section of Small Animal Internal Medicine (Kidd), College of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, California 91766"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"R1","series-title":"Int J Syst Evol Microbiol","first-page":"2145","volume":"51","year":"2001","unstructured":"Dumler JS, Barbet AF, Bekker CP, et al. 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