{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:31:00Z","timestamp":1787841060524,"version":"build-2784847793"},"reference-count":45,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Effusion is the abnormal accumulation of fluid within a body cavity that can result from a variety of disease processes. This article reviews the normal production and resorption of body cavity fluid and the pathophysiology of abnormal fluid accumulation. In addition, classification schemes, differential diagnoses, and currently available diagnostic tests for evaluation of effusions are reviewed.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5558","type":"journal-article","created":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T23:19:49Z","timestamp":1292541589000},"page":"1-11","source":"Crossref","is-referenced-by-count":91,"title":["A Review of the Pathophysiology, Classification, and Analysis of Canine and Feline Cavitary Effusions"],"prefix":"10.5326","volume":"47","author":[{"given":"Suzanne M.","family":"Dempsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patty J.","family":"Ewing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"2","key":"bib1","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"140","article-title":"The cytologic examination of body cavity fluids","volume":"3","author":"O'Brien","year":"1988","unstructured":"O'Brien\n              PJ\n            , LumsdenJH. The cytologic examination of body cavity fluids. Semin Vet Med Surg (Small Anim)1988;3(2):140\u201356."},{"key":"bib2","series-title":"Diagnostic cytology and hematology of the dog and cat","first-page":"235","article-title":"Effusions: abdominal, thoracic, and pericardial","author":"Rizzi","year":"2008","unstructured":"Rizzi\n              TE\n            , CowellRL, TylerRD. Effusions: abdominal, thoracic, and pericardial. In: CowellRL, TylerRD, MeinkothJH, eds. Diagnostic cytology and hematology of the dog and cat. 3rd ed. St. Louis, MO: Mosby; 2008:235\u201355."},{"issue":"3","key":"bib3","series-title":"Vet Clin North Am Small Anim Pract","first-page":"603","article-title":"Diagnosis and management of peritonitis","volume":"30","author":"Swann","year":"2000","unstructured":"Swann\n              H\n            , HughesD. Diagnosis and management of peritonitis. Vet Clin North Am Small Anim Pract2000;30(3):603\u201315, vii."},{"issue":"6","key":"bib4","series-title":"Eur Respir J","first-page":"1545","article-title":"Physiology and pathophysiology of pleural fluid turnover","volume":"20","author":"Zocchi","year":"2002","unstructured":"Zocchi\n              L\n            \n          . Physiology and pathophysiology of pleural fluid turnover. Eur Respir J2002;20(6):1545\u201358."},{"issue":"6","key":"bib5","series-title":"J Vet Intern Med","first-page":"613","article-title":"Serum-effusion albumin gradient in dogs with transudative abdominal effusion","volume":"14","author":"Pembleton-Corbett","year":"2000","unstructured":"Pembleton-Corbett\n              JR\n            , CenterSA, SchermerhornT. Serum-effusion albumin gradient in dogs with transudative abdominal effusion. J Vet Intern Med2000;14(6):613\u20138."},{"issue":"1","key":"bib6","series-title":"Int J Biochem Cell Biol","first-page":"9","article-title":"The mesothelial cell","volume":"36","author":"Mutsaers","year":"2004","unstructured":"Mutsaers\n              SE\n            \n          . The mesothelial cell. Int J Biochem Cell Biol2004;36(1):9\u201316."},{"key":"bib7","series-title":"Fundamentals of veterinary clinical pathology","first-page":"831","article-title":"Cavitary effusions","author":"Stockham","year":"2008","unstructured":"Stockham\n              SL\n            , ScottMA. Cavitary effusions. In: StockhamSL, ScottMA, eds. Fundamentals of veterinary clinical pathology. Ames: Blackwell; 2008:831\u201368."},{"issue":"2","key":"bib8","series-title":"Vet Surg","first-page":"90","article-title":"Surgical treatment of bile peritonitis in 24 dogs and 2 cats: a retrospective study (1987\u20131994)","volume":"26","author":"Ludwig","year":"1997","unstructured":"Ludwig\n              LL\n            , McLoughlinMA, GravesTK. Surgical treatment of bile peritonitis in 24 dogs and 2 cats: a retrospective study (1987\u20131994). Vet Surg1997;26(2):90\u20138."},{"key":"bib9","series-title":"J Vet Emerg Crit Care","first-page":"275","article-title":"Evaluation of abdominal fluid: peripheral blood creatinine and potassium ratios for diagnosis of uroperitoneum in dogs","volume":"11(4)","author":"Schmeidt","year":"2001","unstructured":"Schmeidt\n              C\n            , TobiasKM, OttoCM. Evaluation of abdominal fluid: peripheral blood creatinine and potassium ratios for diagnosis of uroperitoneum in dogs. J Vet Emerg Crit Care2001;11(4):275\u201380."},{"issue":"1","key":"bib10","series-title":"J Am Vet Med Assoc","first-page":"49","article-title":"Evaluation of cholesterol and triglyceride concentrations in differentiating chylous and nonchylous pleural effusions in dogs and cats","volume":"188","author":"Fossum","year":"1986","unstructured":"Fossum\n              TW\n            , JacobsRM, BirchardSJ. Evaluation of cholesterol and triglyceride concentrations in differentiating chylous and nonchylous pleural effusions in dogs and cats. J Am Vet Med Assoc1986;188(1):49\u201351."},{"issue":"2","key":"bib11","series-title":"Vet Surg","first-page":"161","article-title":"Comparison of peritoneal fluid and peripheral blood pH, bicarbonate, glucose, and lactate concentration as a diagnostic tool for septic peritonitis in dogs and cats","volume":"32","author":"Bonczynski","year":"2003","unstructured":"Bonczynski\n              JJ\n            , LudwigLL, BartonLJ. Comparison of peritoneal fluid and peripheral blood pH, bicarbonate, glucose, and lactate concentration as a diagnostic tool for septic peritonitis in dogs and cats. Vet Surg2003;32(2):161\u20136."},{"key":"bib12","series-title":"J Vet Med A Physiol Pathol Clin Med","first-page":"119","article-title":"Comparison of lipase activity in peritoneal fluid of dogs with different pathologies--a complimentary diagnostic tool in acute pancreatitis?","volume":"53(3)","author":"Guija de Arespacochaga","year":"2006","unstructured":"Guija de Arespacochaga\n              A\n            , HittmairKM, SchwendenweinI. Comparison of lipase activity in peritoneal fluid of dogs with different pathologies--a complimentary diagnostic tool in acute pancreatitis?J Vet Med A Physiol Pathol Clin Med2006;53(3):119\u201322."},{"key":"bib13","series-title":"J Vet Emerg Crit Care","first-page":"175","article-title":"Budd-Chiari-like syndrome in a dog with a chondrosarcoma of the thoracic wall","volume":"17(2)","author":"Whelan","year":"2007","unstructured":"Whelan\n              MF\n            , O'TooleTE, CarlsonKR. Budd-Chiari-like syndrome in a dog with a chondrosarcoma of the thoracic wall. J Vet Emerg Crit Care2007;17(2):175\u20138."},{"issue":"1-2","key":"bib14","series-title":"J Virol Methods","first-page":"111","article-title":"A mRNA PCR for the diagnosis of feline infectious peritonitis","volume":"124","author":"Simons","year":"2005","unstructured":"Simons\n              FA\n            , VennemaH, RofinaJE. A mRNA PCR for the diagnosis of feline infectious peritonitis. J Virol Methods2005;124(1-2):111\u20136."},{"key":"bib15","series-title":"J Vet Emerg Crit Care","first-page":"147","article-title":"Pyothorax in a neonatal boxer","volume":"11(2)","author":"Schoeffler","year":"2001","unstructured":"Schoeffler\n              GL\n            , RozanskiEA, RushJE. Pyothorax in a neonatal boxer. J Vet Emerg Crit Care2001;11(2):147\u201352."},{"issue":"6","key":"bib16","series-title":"J Am Vet Med Assoc","first-page":"819","article-title":"Risk factors, prognostic indicators, and outcome of pyothorax in cats: 80 cases (1986\u20131999)","volume":"221","author":"Waddell","year":"2002","unstructured":"Waddell\n              LS\n            , BradyCA, DrobatzKJ. Risk factors, prognostic indicators, and outcome of pyothorax in cats: 80 cases (1986\u20131999). J Am Vet Med Assoc2002;221(6):819\u201324."},{"issue":"5","key":"bib17","series-title":"J Am Anim Hosp Assoc","first-page":"364","article-title":"Lactate as a diagnostic test for septic peritoneal effusions in dogs and cats","volume":"40","author":"Levin","year":"2004","unstructured":"Levin\n              GM\n            , BonczynskiJJ, LudwigLL. Lactate as a diagnostic test for septic peritoneal effusions in dogs and cats. J Am Anim Hosp Assoc2004;40(5):364\u201371."},{"issue":"6","key":"bib18","series-title":"J Vet Intern Med","first-page":"781","article-title":"Comparison of different tests to diagnose feline infectious peritonitis","volume":"17","author":"Hartmann","year":"2003","unstructured":"Hartmann\n              K\n            , BinderC, HirschbergerJ. Comparison of different tests to diagnose feline infectious peritonitis. J Vet Intern Med2003;17(6):781\u201390."},{"key":"bib19","series-title":"Canine and feline cytology: a color atlas and interpretation guide","first-page":"171","article-title":"Body cavity fluids","author":"Rebar","year":"2010","unstructured":"Rebar\n              AH\n            , ThompsonCA. Body cavity fluids. In: RaskinRE, MeyerDJ, eds. Canine and feline cytology: a color atlas and interpretation guide. St. Louis, Mo: Saunders; 2010:171\u201391."},{"key":"bib20","series-title":"J Vet Emerg Crit Care","first-page":"292","article-title":"Non-coagulopathic spontaneous hemothorax in dogs","volume":"18(3)","author":"Nakamura","year":"2008","unstructured":"Nakamura\n              RK\n            , RozanskiEA, RushJE. Non-coagulopathic spontaneous hemothorax in dogs. J Vet Emerg Crit Care2008;18(3):292\u20137."},{"issue":"4","key":"bib21","series-title":"J Am Vet Med Assoc","first-page":"553","article-title":"Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003\u20132005)","volume":"232","author":"Hammond","year":"2008","unstructured":"Hammond\n              TN\n            , Pesillo-CrosbySA. Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003\u20132005). J Am Vet Med Assoc2008;232(4):553\u20138."},{"key":"bib22","series-title":"J Vet Emerg Crit Care","first-page":"93","article-title":"Feline hemoperitoneum 16 cases (1986\u20131993)","volume":"5(2)","author":"Mandell","year":"1995","unstructured":"Mandell\n              DC\n            , DrobatzK. Feline hemoperitoneum 16 cases (1986\u20131993). J Vet Emerg Crit Care1995;5(2):93\u20137."},{"issue":"1","key":"bib23","series-title":"J Am Vet Med Assoc","first-page":"51","article-title":"Diagnostic value of pericardial fluid analysis in the dog","volume":"184","author":"Sisson","year":"1984","unstructured":"Sisson\n              D\n            , ThomasWP, RuehlWW. Diagnostic value of pericardial fluid analysis in the dog. J Am Vet Med Assoc1984;184(1):51\u20135."},{"key":"bib24","series-title":"J Vet Emerg Crit Care","first-page":"136","article-title":"Septic pericarditis in a Yorkshire Terrier","volume":"16(2)","author":"Wagner","year":"2006","unstructured":"Wagner\n              A\n            , MacGregorJM, BergJ. Septic pericarditis in a Yorkshire Terrier. J Vet Emerg Crit Care2006;16(2):136\u201340."},{"issue":"6","key":"bib25","series-title":"J Vet Intern Med","first-page":"923","article-title":"Pericardial effusion due to primary cardiac lymphosarcoma in a dog","volume":"17","author":"Sims","year":"2003","unstructured":"Sims\n              CS\n            , TobiasAH, HaydenDW. Pericardial effusion due to primary cardiac lymphosarcoma in a dog. J Vet Intern Med2003;17(6):923\u20137."},{"issue":"3","key":"bib26","series-title":"J Vet Intern Med","first-page":"354","article-title":"Cholesterol-based pericardial effusion and aortic thromboembolism in a 9-year-old mixed-breed dog with hypothyroidism","volume":"18","author":"MacGregor","year":"2004","unstructured":"MacGregor\n              JM\n            , RozanskiEA, McCarthyRJ. Cholesterol-based pericardial effusion and aortic thromboembolism in a 9-year-old mixed-breed dog with hypothyroidism. J Vet Intern Med2004;18(3):354\u20138."},{"issue":"12","key":"bib27","series-title":"J Am Vet Med Assoc","first-page":"1930","article-title":"Idiopathic primary chylopericardium in a dog","volume":"229","author":"Boston","year":"2006","unstructured":"Boston\n              SE\n            , MoensNM, MartinDM. Idiopathic primary chylopericardium in a dog. J Am Vet Med Assoc2006;229(12):1930\u20133."},{"issue":"1","key":"bib28","series-title":"J Am Anim Hosp Assoc","first-page":"63","article-title":"The diagnostic value of pericardial fluid pH determination","volume":"32","author":"Edwards","year":"1996","unstructured":"Edwards\n              NJ\n            \n          . The diagnostic value of pericardial fluid pH determination. J Am Anim Hosp Assoc1996;32(1):63\u20137."},{"issue":"6","key":"bib29","series-title":"J Vet Intern Med","first-page":"833","article-title":"Biochemical analysis of pericardial fluid and whole blood in dogs with pericardial effusion","volume":"19","author":"de Laforcade","year":"2005","unstructured":"de Laforcade\n              AM\n            , FreemanLM, RozanskiEA. Biochemical analysis of pericardial fluid and whole blood in dogs with pericardial effusion. J Vet Intern Med2005;19(6):833\u20136."},{"issue":"4","key":"bib30","series-title":"J Am Vet Med Assoc","first-page":"575","article-title":"Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy: 23 cases (1986\u20132000)","volume":"226","author":"Weisse","year":"2005","unstructured":"Weisse\n              C\n            , SoaresN, BealMW. Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy: 23 cases (1986\u20132000). J Am Vet Med Assoc2005;226(4):575\u20139."},{"issue":"4","key":"bib31","series-title":"J Vet Intern Med","first-page":"525","article-title":"Use of pericardial fluid pH to distinguish between idiopathic and neoplastic effusions","volume":"17","author":"Fine","year":"2003","unstructured":"Fine\n              DM\n            , TobiasAH, JacobKA. Use of pericardial fluid pH to distinguish between idiopathic and neoplastic effusions. J Vet Intern Med2003;17(4):525\u20139."},{"issue":"3","key":"bib32","series-title":"J Vet Intern Med","first-page":"322","article-title":"Cardiac troponins I and T in dogs with pericardial effusion","volume":"18","author":"Shaw","year":"2004","unstructured":"Shaw\n              SP\n            , RozanskiEA, RushJE. Cardiac troponins I and T in dogs with pericardial effusion. J Vet Intern Med2004;18(3):322\u20134."},{"issue":"5","key":"bib33","series-title":"J Vet Intern Med","first-page":"1002","article-title":"Pericardial effusion in cats: a retrospective study of clinical findings and outcome in 146 cats","volume":"21","author":"Hall","year":"2007","unstructured":"Hall\n              DJ\n            , ShoferF, MeierCK. Pericardial effusion in cats: a retrospective study of clinical findings and outcome in 146 cats. J Vet Intern Med2007;21(5):1002\u20137."},{"key":"bib34","series-title":"J Am Anim Hosp Assoc","first-page":"39","article-title":"Pericardial disease in the cat: a retrospective evaluation of 66 cases","volume":"26","author":"Rush","year":"1990","unstructured":"Rush\n              JE\n            , KeeneBW, FoxPR. Pericardial disease in the cat: a retrospective evaluation of 66 cases. J Am Anim Hosp Assoc1990;26:39\u201346."},{"issue":"11","key":"bib35","series-title":"Mayo Clin Proc","first-page":"700","article-title":"The lipoprotein profile of chylous and nonchylous pleural effusions","volume":"55","author":"Staats","year":"1980","unstructured":"Staats\n              BA\n            , EllefsonRD, BudahnLL. The lipoprotein profile of chylous and nonchylous pleural effusions. Mayo Clin Proc1980;55(11):700\u20134."},{"issue":"4","key":"bib36","series-title":"J Am Vet Med Assoc","first-page":"672","article-title":"Chylothorax in cats: 37 cases (1969\u20131989)","volume":"198","author":"Fossum","year":"1991","unstructured":"Fossum\n              TW\n            , ForresterSD, SwensonCL. Chylothorax in cats: 37 cases (1969\u20131989). J Am Vet Med Assoc1991;198(4):672\u20138."},{"issue":"3","key":"bib37","series-title":"Vet Clin Pathol","first-page":"80","article-title":"Lipoprotein electrophoresis differentiation of chylous and nonchylous pleural effusions in dogs and cats and its correlation with pleural effusion triglyceride concentration","volume":"19","author":"Waddle","year":"1990","unstructured":"Waddle\n              JR\n            , GigerU. Lipoprotein electrophoresis differentiation of chylous and nonchylous pleural effusions in dogs and cats and its correlation with pleural effusion triglyceride concentration. Vet Clin Pathol1990;19(3):80\u20135."},{"issue":"1","key":"bib38","series-title":"J Vet Intern Med","first-page":"186","article-title":"Isolation or molecular detection of Bartonella henselae and Bartonella vinsonii subsp. berkhoffii from dogs with idiopathic cavitary effusions","volume":"23","author":"Cherry","year":"2009","unstructured":"Cherry\n              NA\n            , DinizPP, MaggiRG. Isolation or molecular detection of Bartonella henselae and Bartonella vinsonii subsp. berkhoffii from dogs with idiopathic cavitary effusions. J Vet Intern Med2009;23(1):186\u20139."},{"issue":"4","key":"bib39","series-title":"J Am Anim Hosp Assoc","first-page":"315","article-title":"Uroperitoneum in cats: 26 cases (1986\u20131995)","volume":"34","author":"Aumann","year":"1998","unstructured":"Aumann\n              M\n            , WorthLT, DrobatzKJ. Uroperitoneum in cats: 26 cases (1986\u20131995). J Am Anim Hosp Assoc1998;34(4):315\u201324."},{"key":"bib40","series-title":"Small animal clinical oncology","first-page":"699","article-title":"Hematopoietic tumors","author":"Vail","year":"2007","unstructured":"Vail\n              DM\n            , YoungKM. Hematopoietic tumors. In: WithrowSJ, VailDM, eds. Small animal clinical oncology. 4th ed.St. Louis: Saunders; 2007:699\u2013784."},{"issue":"1","key":"bib41","series-title":"Vet Pathol","first-page":"32","article-title":"Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes","volume":"40","author":"Burnett","year":"2003","unstructured":"Burnett\n              RC\n            , VernauW, ModianoJF. Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes. Vet Pathol2003;40(1):32\u201341."},{"issue":"2","key":"bib42","series-title":"Vet Clin Pathol","first-page":"72","article-title":"Application of flow cytometric techniques to veterinary clinical hematology","volume":"31","author":"Weiss","year":"2002","unstructured":"Weiss\n              DJ\n            \n          . Application of flow cytometric techniques to veterinary clinical hematology. Vet Clin Pathol2002;31(2):72\u201382."},{"issue":"2","key":"bib43","series-title":"J Vet Intern Med","first-page":"164","article-title":"Vascular endothelial growth factor concentrations in body cavity effusions in dogs","volume":"16","author":"Clifford","year":"2002","unstructured":"Clifford\n              CA\n            , HughesD, BealMW. Vascular endothelial growth factor concentrations in body cavity effusions in dogs. J Vet Intern Med2002;16(2):164\u20138."},{"issue":"2","key":"bib44","series-title":"J Vet Intern Med","first-page":"146","article-title":"Telomerase enzyme activity as a diagnostic tool to distinguish effusions of malignant and benign origin","volume":"14","author":"Spangler","year":"2000","unstructured":"Spangler\n              EA\n            , RogersKS, ThomasJS. Telomerase enzyme activity as a diagnostic tool to distinguish effusions of malignant and benign origin. J Vet Intern Med2000;14(2):146\u201350."},{"issue":"5","key":"bib45","series-title":"J Vet Intern Med","first-page":"321","article-title":"Fibronectin concentrations in pleural and abdominal effusions in dogs and cats","volume":"10","author":"Hirschberger","year":"1996","unstructured":"Hirschberger\n              J\n            , PuschS. Fibronectin concentrations in pleural and abdominal effusions in dogs and cats. 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