{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:02:57Z","timestamp":1772326977991,"version":"3.50.1"},"reference-count":50,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"abstract":"A 6 yr old, male, neutered Weimaraner was treated homeopathically for nasal aspergillosis after failing to respond to two treatments of topical (intranasal) clotrimazole and oral amoxicillin trihydrate\/clavulanate potassium. Computed tomography, rhinoscopy, fungal culture, and cytology previously confirmed the diagnosis. At presentation for homeopathic treatment, the dog had aggressive left-sided sinusitis and rhinitis with destruction of nasal turbinates and severe bouts of epistaxis. Erosion and depigmentation of the nasal planum were evident. After two treatments with homeopathic aurum metallicum, resolution of clinical signs occurred and clearance of the aspergillosis organisms was documented by computed tomographic scan, rhinoscopy, and histopathology. Homeopathic aurum metallicum may be beneficial in treating cases of canine nasal aspergillosis.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5560","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T12:29:53Z","timestamp":1320409793000},"page":"e110-e115","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Resolution of Nasal Aspergillosis Following Therapy with a Homeopathic Remedy in a Dog"],"prefix":"10.5326","volume":"47","author":[{"given":"Shelley","family":"Epstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"bib1","series-title":"Infectious diseases of the dog and cat","first-page":"404","article-title":"Canine nasal aspergillosis-penicilliosis","author":"Sharp","year":"1998","unstructured":"Sharp\n NJ\n \n . 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J Am Vet Med Assoc.2002;221:1421\u20135."},{"issue":"5","key":"bib4","series-title":"Vet Clin North Am Small Anim Pract.","first-page":"901","article-title":"Update on canine sinonasal aspergillosis","volume":"37","author":"Peeters","year":"2007","unstructured":"Peeters\n D\n , ClercxC. Update on canine sinonasal aspergillosis. Vet Clin North Am Small Anim Pract.2007;37(5):901\u201316, vi."},{"issue":"1","key":"bib5","series-title":"J Am Vet Med Assoc.","first-page":"48","article-title":"Nasal aspergillosis and penicilliosis in dogs: results of treatment with thiabendazole","volume":"184","author":"Harvey","year":"1984","unstructured":"Harvey\n CE\n \n . Nasal aspergillosis and penicilliosis in dogs: results of treatment with thiabendazole. J Am Vet Med Assoc.1984;184(1):48\u201350."},{"issue":"6","key":"bib6","series-title":"J Am Vet Med Assoc.","first-page":"782","article-title":"Use of ketoconazole in the treatment of canine nasal aspergillosis","volume":"194","author":"Sharp","year":"1989","unstructured":"Sharp\n NJ\n , SullivanM. Use of ketoconazole in the treatment of canine nasal aspergillosis. J Am Vet Med Assoc.1989;194(6):782\u20136."},{"key":"bib7","series-title":"Kirk's current veterinary therapy XII small animal practice","first-page":"327","article-title":"Antimycotic drug therapy","author":"Legendre","year":"1995","unstructured":"Legendre\n A\n \n . Antimycotic drug therapy. In: BonaguraJ, ed. Kirk's current veterinary therapy XII small animal practice. 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Computed tomographic imaging of nasal disease in 100 dogs. Vet Radiol Ultrasound.1992;33:177\u201380."},{"issue":"4","key":"bib20","series-title":"Vet Radiol Ultrasound.","first-page":"414","article-title":"Comparison of radiography and computed tomography for the diagnosis of canine nasal aspergillosis","volume":"44","author":"Saunders","year":"2003","unstructured":"Saunders\n JH\n , van Breeh. Comparison of radiography and computed tomography for the diagnosis of canine nasal aspergillosis. Vet Radiol Ultrasound.2003;44(4):414\u201319."},{"issue":"4","key":"bib21","series-title":"Vet Surg","first-page":"309","article-title":"Computed tomographic assessment of noninvasive intranasal infusions in dogs with fungal rhinitis","volume":"25","author":"Mathews","year":"1996","unstructured":"Mathews\n KG\n , KoblikPD, RichardsonEF. Computed tomographic assessment of noninvasive intranasal infusions in dogs with fungal rhinitis. 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J Am Hol Vet Med Assoc.2006;25:9\u201316."},{"issue":"12","key":"bib25","series-title":"Vet Rec.","first-page":"364","article-title":"Pilot study of the effect of individualised homeopathy on the pruritus associated with atopic dermatitis in dogs","volume":"164","author":"Hill","year":"2009","unstructured":"Hill\n PB\n , HoareJ, Lau-GillardP. Pilot study of the effect of individualised homeopathy on the pruritus associated with atopic dermatitis in dogs. Vet Rec.2009;164(12):364\u201370."},{"key":"bib1","series-title":"Infectious diseases of the dog and cat","first-page":"404","article-title":"Canine nasal aspergillosis-penicilliosis","author":"Sharp","year":"1998","unstructured":"Sharp\n NJ\n \n . Canine nasal aspergillosis-penicilliosis. In: GreeneCE, ed. Infectious diseases of the dog and cat. 2nd ed. Philadelphia: WB Saunders Co; 1998:404\u20139."},{"key":"bib2","series-title":"Kirk's current veterinary therapy XII small animal practice","first-page":"899","article-title":"Treatment of nasal aspergillosis with topical clotrimazole","author":"Davidson","year":"1995","unstructured":"Davidson\n AP\n , PappagianisD. Treatment of nasal aspergillosis with topical clotrimazole. In: BonaguraJD, ed. Kirk's current veterinary therapy XII small animal practice. Philadelphia: WB Saunders Co; 1995:899\u2013901."},{"key":"bib3","series-title":"J Am Vet Med Assoc.","first-page":"1421","article-title":"Intranasal infusion of enilconazole for treatment of sinonasal aspergillosis in dogs","volume":"221","author":"Zonderland","year":"2002","unstructured":"Zonderland\n JL\n , StorkCK, SaundersJH. Intranasal infusion of enilconazole for treatment of sinonasal aspergillosis in dogs. J Am Vet Med Assoc.2002;221:1421\u20135."},{"issue":"5","key":"bib4","series-title":"Vet Clin North Am Small Anim Pract.","first-page":"901","article-title":"Update on canine sinonasal aspergillosis","volume":"37","author":"Peeters","year":"2007","unstructured":"Peeters\n D\n , ClercxC. Update on canine sinonasal aspergillosis. Vet Clin North Am Small Anim Pract.2007;37(5):901\u201316, vi."},{"issue":"1","key":"bib5","series-title":"J Am Vet Med Assoc.","first-page":"48","article-title":"Nasal aspergillosis and penicilliosis in dogs: results of treatment with thiabendazole","volume":"184","author":"Harvey","year":"1984","unstructured":"Harvey\n CE\n \n . Nasal aspergillosis and penicilliosis in dogs: results of treatment with thiabendazole. J Am Vet Med Assoc.1984;184(1):48\u201350."},{"issue":"6","key":"bib6","series-title":"J Am Vet Med Assoc.","first-page":"782","article-title":"Use of ketoconazole in the treatment of canine nasal aspergillosis","volume":"194","author":"Sharp","year":"1989","unstructured":"Sharp\n NJ\n , SullivanM. Use of ketoconazole in the treatment of canine nasal aspergillosis. J Am Vet Med Assoc.1989;194(6):782\u20136."},{"key":"bib7","series-title":"Kirk's current veterinary therapy XII small animal practice","first-page":"327","article-title":"Antimycotic drug therapy","author":"Legendre","year":"1995","unstructured":"Legendre\n A\n \n . Antimycotic drug therapy. In: BonaguraJ, ed. Kirk's current veterinary therapy XII small animal practice. Philadelphia: WB Saunders Co; 1995:327\u201331."},{"key":"bib8","series-title":"J Small Anim Pract.","first-page":"513","article-title":"Treatment of canine nasal aspergillosis\/penicilliosis with fluconazole","volume":"32","author":"Sharp","year":"1991","unstructured":"Sharp\n NJH\n , HarveyCE, ObrienJA. Treatment of canine nasal aspergillosis\/penicilliosis with fluconazole. J Small Anim Pract.1991;32:513\u20136."},{"key":"bib9","series-title":"Kirk's current veterinary therapy XIII small animal practice","first-page":"315","article-title":"CVT update: therapy for nasal aspergillosis","author":"Davidson","year":"2000","unstructured":"Davidson\n AP\n , MathewsKG. CVT update: therapy for nasal aspergillosis. In: BonaguraJD, ed. Kirk's current veterinary therapy XIII small animal practice. Philadelphia: WB Saunders Co; 2000:315\u20137."},{"issue":"6","key":"bib10","series-title":"J Am Anim Hosp Assoc.","first-page":"487","article-title":"Management of nasal aspergillosis in a dog with a single, noninvasive intranasal infusion of clotrimazole","volume":"34","author":"Smith","year":"1998","unstructured":"Smith\n SA\n , AndrewsG, BillerDS. Management of nasal aspergillosis in a dog with a single, noninvasive intranasal infusion of clotrimazole. J Am Anim Hosp Assoc.1998;34(6):487\u201392."},{"issue":"6","key":"bib11","series-title":"J Small Anim Pract.","first-page":"312","article-title":"Combined clotrimazole irrigation and depot therapy for canine nasal aspergillosis","volume":"47","author":"Sissener","year":"2006","unstructured":"Sissener\n TR\n , BaconNJ, FriendE. Combined clotrimazole irrigation and depot therapy for canine nasal aspergillosis. J Small Anim Pract.2006;47(6):312\u20135."},{"issue":"1","key":"bib12","series-title":"Vet Surg.","first-page":"43","article-title":"Open nasal cavity and frontal sinus treatment of chronic canine aspergillosis","volume":"20","author":"Pavletic","year":"1991","unstructured":"Pavletic\n MM\n , ClarkGN. Open nasal cavity and frontal sinus treatment of chronic canine aspergillosis. Vet Surg.1991;20(1):43\u20138."},{"issue":"6","key":"bib13","series-title":"J Small Anim Pract.","first-page":"320","article-title":"Surgical treatment of canine nasal aspergillosis by rhinotomy combined with enilconazole infusion and oral itraconazole","volume":"47","author":"Claeys","year":"2006","unstructured":"Claeys\n S\n , LefebvreJB, SchullerS. Surgical treatment of canine nasal aspergillosis by rhinotomy combined with enilconazole infusion and oral itraconazole. J Small Anim Pract.2006;47(6):320\u20134."},{"key":"bib14","series-title":"Organon of the medical art","first-page":"152","article-title":"Acquiring a knowledge of medicines","volume":"72\u20133","author":"Hahnemann","year":"1996","unstructured":"Hahnemann\n S\n \n . Acquiring a knowledge of medicines. In: O'ReillyWB, ed. Organon of the medical art. Redmond, Washington: Birdcage Books, 1996;72\u20133, 152\u201361."},{"key":"bib15","series-title":"Materia medica pura","first-page":"179","article-title":"Aurum metallicum","author":"Hahnemann","year":"2007","unstructured":"Hahnemann\n S\n \n . Aurum metallicum. In: Materia medica pura. New Delhi: B. Jain Publishers (P) Ltd; 2007;179\u201397."},{"key":"bib16","series-title":"Compend Contin Educ Pract Vet.","first-page":"41","article-title":"Canine nasal aspergillosis and penicilliosis","volume":"13","author":"Sharp","year":"1991","unstructured":"Sharp\n NJH\n , HarveyCE, SullivanM. Canine nasal aspergillosis and penicilliosis. 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Computed tomographic imaging of nasal disease in 100 dogs. Vet Radiol Ultrasound.1992;33:177\u201380."},{"issue":"4","key":"bib20","series-title":"Vet Radiol Ultrasound.","first-page":"414","article-title":"Comparison of radiography and computed tomography for the diagnosis of canine nasal aspergillosis","volume":"44","author":"Saunders","year":"2003","unstructured":"Saunders\n JH\n , van Breeh. Comparison of radiography and computed tomography for the diagnosis of canine nasal aspergillosis. Vet Radiol Ultrasound.2003;44(4):414\u201319."},{"issue":"4","key":"bib21","series-title":"Vet Surg","first-page":"309","article-title":"Computed tomographic assessment of noninvasive intranasal infusions in dogs with fungal rhinitis","volume":"25","author":"Mathews","year":"1996","unstructured":"Mathews\n KG\n , KoblikPD, RichardsonEF. Computed tomographic assessment of noninvasive intranasal infusions in dogs with fungal rhinitis. 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