{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:14:19Z","timestamp":1769728459063,"version":"3.49.0"},"reference-count":30,"publisher":"American Animal Hospital Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>A 7 yr old Labrador retriever initially presented for severe halitosis, mild ptylism, and depigmentation of the nasal planum. Erythema multiforme was diagnosed based on clinical signs and dermatopathology. Treatment was initiated but the condition did not resolve. Six months later, the dog was diagnosed with a mediastinal mass. Trucut biopsy was performed and histopathologic diagnosis was consistent with a thymoma. A median sternotomy was performed, the thymoma was excised, and the dog recovered well. Four months postoperatively, there were no longer any obvious erythema multiforme lesions and the skin condition was controlled without medication. Erythema multiforme may be a paraneoplastic disorder associated with thymoma in the dog, similar to thymoma-associated exfoliative dermatitis in the cat. Clinical signs of erythema multiforme may warrant performing thoracic radiographs or thoracic CT to rule out thymoma as an underlying cause.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5561","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:36:57Z","timestamp":1297384617000},"page":"e19-e25","source":"Crossref","is-referenced-by-count":26,"title":["Diagnosis of Erythema Multiforme Associated with Thymoma in a Dog and Treated with Thymectomy"],"prefix":"10.5326","volume":"47","author":[{"given":"Laura C.","family":"Tepper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian B.","family":"Spiegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett J.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"4","key":"bib1","series-title":"Vet Dermatol","first-page":"297","article-title":"Erythema multiforme in dogs and cats: literature review and case material from the Cornell University College of Veterinary Medicine (1988\u201396)","volume":"10","author":"Scott","year":"1999","unstructured":"Scott\n              DW\n            , MillerWH. Erythema multiforme in dogs and cats: literature review and case material from the Cornell University College of Veterinary Medicine (1988\u201396). Vet Dermatol1999;10(4):297\u2013308."},{"key":"bib2","series-title":"Canine & feline dermatology: diagnosis and treatment","first-page":"148","article-title":"Erythema multiforme","author":"Nesbitt","year":"1998","unstructured":"Nesbitt\n              GH\n            , AckermanL. Erythema multiforme. In: NesbittGH, AckermanL, eds. Canine & feline dermatology: diagnosis and treatment. Trenton: Veterinary Learning Systems; 1998:148\u201351."},{"key":"bib3","series-title":"Skin diseases of the dog and cat. Clinical and histopathologic diagnosis","first-page":"65","article-title":"Interface diseases of the dermal-epidermal junction","author":"Gross","year":"2005","unstructured":"Gross\n              TL\n            , IhrkePJ, WalderEJ. Interface diseases of the dermal-epidermal junction. In: GrossTL, IhrkePJ, WalderEJ, eds. Skin diseases of the dog and cat. Clinical and histopathologic diagnosis. 2nd ed. Oxford: Wiley-Blackwell; 2005:65\u201370."},{"key":"bib4","series-title":"Advances in veterinary dermatology","first-page":"103","article-title":"Immunochemical characterization of canine acute graft-versus host disease and Erythema Multiforme","author":"Affolter","year":"1998","unstructured":"Affolter\n              VK\n            , MoorePF, SandmaierBM. Immunochemical characterization of canine acute graft-versus host disease and Erythema Multiforme. In: KwochkaKW, WillemseT, TscharnerC, eds. Advances in veterinary dermatology. Oxford: Butterworth-Heinemann; 1998:103\u201315."},{"key":"bib5","series-title":"Textbook of veterinary internal medicine","first-page":"31","article-title":"The skin as a sensor of internal medical disorders","author":"Merchant","year":"2005","unstructured":"Merchant\n              SR\n            \n          . The skin as a sensor of internal medical disorders. In: EttingerSJ, FeldmanEC, eds. Textbook of veterinary internal medicine. 6th ed. St. Louis: Elsevier; 2005:31."},{"issue":"8","key":"bib6","series-title":"J Vet Med Sci","first-page":"869","article-title":"Erythema multiforme possibly triggered by food substances in a dog","volume":"68","author":"Itoh","year":"2006","unstructured":"Itoh\n              T\n            , NibeK, KojimotoA. Erythema multiforme possibly triggered by food substances in a dog. J Vet Med Sci2006;68(8):869\u201371."},{"key":"bib7","series-title":"Vet Aller Clin Immunol","first-page":"13","article-title":"Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis in the dog. Clinical classification, drug exposure and histopathological correlations","volume":"6","author":"Hinn","year":"1998","unstructured":"Hinn\n              AC\n            , OlivryT, LutherPB. Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis in the dog. Clinical classification, drug exposure and histopathological correlations. Vet Aller Clin Immunol1998;6:13\u201320."},{"issue":"1","key":"bib8","series-title":"Vet Pathol","first-page":"88","article-title":"Paraneoplastic pemphigus in a dog with splenic sarcoma","volume":"42","author":"Elmore","year":"2005","unstructured":"Elmore\n              SA\n            , BassechesJ, AnhaltGJ. Paraneoplastic pemphigus in a dog with splenic sarcoma. Vet Pathol2005;42(1):88\u201391."},{"issue":"6","key":"bib9","series-title":"Vet Pathol","first-page":"647","article-title":"Parvovirus infection of keratinocytes as a cause of canine erythema multiforme","volume":"37","author":"Favrot","year":"2000","unstructured":"Favrot\n              C\n            , OlivryT, DunstonSM. Parvovirus infection of keratinocytes as a cause of canine erythema multiforme. Vet Pathol2000;37(6):647\u20139."},{"issue":"7","key":"bib10","series-title":"Compendium","first-page":"603","article-title":"Pentoxifylline","volume":"23","author":"Gutierres","year":"2001","unstructured":"Gutierres\n              S\n            \n          . Pentoxifylline. Compendium2001;23(7):603\u20135."},{"key":"bib11","series-title":"Muller & Kirk's small animal dermatology","first-page":"241","article-title":"Dermatologic therapy","author":"Scott","year":"2001","unstructured":"Scott\n              DW\n            , MillerWH, GriffinCE. Dermatologic therapy. In: ScottDW, MillerWH, GriffinCE, eds. Muller & Kirk's small animal dermatology. 6th ed. Philadelphia: Saunders; 2001:241."},{"issue":"10","key":"bib12","series-title":"J Am Vet Med Assoc","first-page":"1497","article-title":"Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs","volume":"200","author":"White","year":"1992","unstructured":"White\n              SD\n            , RosychukRA, ReinkeSI. Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs. J Am Vet Med Assoc1992;200(10):1497\u2013500."},{"key":"bib13","series-title":"Small animal clinical oncology","first-page":"646","article-title":"Thymoma","author":"Withrow","year":"2001","unstructured":"Withrow\n              SJ\n            \n          . Thymoma. In: WithrowSJ, MacEwenEG, eds. Small animal clinical oncology. 3rd ed. Wisconsin: Saunders; 2001:646\u201351."},{"key":"bib14","series-title":"J Am Anim Hosp Assoc","first-page":"63","article-title":"Thymoma and acquired myasthenia gravis in the dog: a case report and review of 13 additional cases","volume":"28","author":"Klebanow","year":"1992","unstructured":"Klebanow\n              ER\n            \n          . Thymoma and acquired myasthenia gravis in the dog: a case report and review of 13 additional cases. J Am Anim Hosp Assoc1992;28:63\u20138."},{"key":"bib15","series-title":"Tumors in domestic animals","first-page":"165","article-title":"Tumors of the hemolymphatic system","author":"Jacobs","year":"2002","unstructured":"Jacobs\n              RM\n            , MessickJB, ValliVE. Tumors of the hemolymphatic system. In: MeutenDJ, ed. Tumors in domestic animals. 4th ed. Ames: Wiley-Blackwell; 2002:165\u201370."},{"issue":"5","key":"bib16","series-title":"Vet Pathol","first-page":"353","article-title":"Thymomas in domestic animals","volume":"13","author":"Parker","year":"1976","unstructured":"Parker\n              GA\n            , CaseyHW. Thymomas in domestic animals. Vet Pathol1976;13(5):353\u201364."},{"key":"bib17","series-title":"J Am Anim Hosp Assoc","first-page":"95","article-title":"Invasive thymoma in a dog: a case report","volume":"13","author":"Robinson","year":"1977","unstructured":"Robinson\n              WC\n            , CantwellHD, CrawleyRR. Invasive thymoma in a dog: a case report. J Am Anim Hosp Assoc1977;13:95\u20137."},{"issue":"8","key":"bib18","series-title":"J Am Vet Med Assoc","first-page":"1186","article-title":"Results of excision of thymoma in cats and dogs: 20 cases (1984\u20132005)","volume":"232","author":"Zitz","year":"2008","unstructured":"Zitz\n              JC\n            , BirchardSJ, CoutoGC. Results of excision of thymoma in cats and dogs: 20 cases (1984\u20132005). J Am Vet Med Assoc2008;232(8):1186\u201392."},{"issue":"5","key":"bib19","series-title":"J Am Anim Hosp Assoc","first-page":"489","article-title":"Radiation therapy in the treatment of canine and feline thymomas: a retrospective study (1985\u20131999)","volume":"37","author":"Smith","year":"2001","unstructured":"Smith\n              AN\n            , WrightJC, BrawnerWRJr. Radiation therapy in the treatment of canine and feline thymomas: a retrospective study (1985\u20131999). J Am Anim Hosp Assoc2001;37(5):489\u201396."},{"issue":"3","key":"bib20","series-title":"J Am Vet Med Assoc","first-page":"306","article-title":"Thymoma in the dog: two case reports and review of 20 additional cases","volume":"183","author":"Bellah","year":"1983","unstructured":"Bellah\n              JR\n            , StiffME, RussellRG. Thymoma in the dog: two case reports and review of 20 additional cases. J Am Vet Med Assoc1983;183(3):306\u201311."},{"issue":"7","key":"bib21","series-title":"J Am Vet Med Assoc","first-page":"1007","article-title":"Thymoma in dogs: 23 cases (1980\u20131991)","volume":"205","author":"Atwater","year":"1994","unstructured":"Atwater\n              SW\n            , PowersBE, ParkRD. Thymoma in dogs: 23 cases (1980\u20131991). J Am Vet Med Assoc1994;205(7):1007\u201313."},{"issue":"2","key":"bib22","series-title":"J Am Anim Hosp Assoc","first-page":"111","article-title":"Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy","volume":"32","author":"Lainesse","year":"1996","unstructured":"Lainesse\n              MF\n            , TaylorSM, MyersSL. Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy. J Am Anim Hosp Assoc1996;32(2):111\u20137."},{"key":"bib23","series-title":"J Am Anim Hosp Assoc","first-page":"281","article-title":"Hypercalcemia in a dog with thymoma","volume":"27","author":"Harris","year":"1991","unstructured":"Harris\n              CL\n            , KlausnerJS, CaywoodDD. Hypercalcemia in a dog with thymoma. J Am Anim Hosp Assoc1991;27:281\u20134."},{"issue":"8","key":"bib24","series-title":"J Am Vet Med Assoc","first-page":"1205","article-title":"Use of a jugular vein autograft for reconstruction of the cranial vena cava in a dog with invasive thymoma and cranial vena cava syndrome","volume":"225","author":"Holsworth","year":"2004","unstructured":"Holsworth\n              IG\n            , KylesAE, BailiffNL. Use of a jugular vein autograft for reconstruction of the cranial vena cava in a dog with invasive thymoma and cranial vena cava syndrome. J Am Vet Med Assoc2004;225(8):1205\u201310, 1196."},{"issue":"5","key":"bib25","series-title":"J Vet Intern Med","first-page":"1161","article-title":"Diagnosis of mediastinal masses in dogs by flow cytometry","volume":"20","author":"Lana","year":"2006","unstructured":"Lana\n              S\n            , PlazaS, HampeK. Diagnosis of mediastinal masses in dogs by flow cytometry. J Vet Intern Med2006;20(5):1161\u20135."},{"issue":"4","key":"bib26","series-title":"Vet Dermatol","first-page":"281","article-title":"Thymoma-associated exfoliative dermatitis in a rabbit","volume":"16","author":"Florizoone","year":"2005","unstructured":"Florizoone\n              K\n            \n          . Thymoma-associated exfoliative dermatitis in a rabbit. Vet Dermatol2005;16(4):281\u20134."},{"issue":"5","key":"bib27","series-title":"N Z Vet J","first-page":"244","article-title":"Feline paraneoplastic syndrome associated with thymoma","volume":"51","author":"Smits","year":"2003","unstructured":"Smits\n              B\n            , ReidMM. Feline paraneoplastic syndrome associated with thymoma. N Z Vet J2003;51(5):244\u20137."},{"key":"bib28","series-title":"Vet Pathol","first-page":"507","article-title":"Necrolytic dermatitis in a cat with sclerosing thymoma","volume":"36","author":"Walder","year":"1999","unstructured":"Walder\n              EJ\n            , KornetME. Necrolytic dermatitis in a cat with sclerosing thymoma. Vet Pathol1999;36:507."},{"issue":"4","key":"bib29","series-title":"Vet Pathol","first-page":"429","article-title":"Thymoma-associated exfoliative dermatitis in cats","volume":"41","author":"Rottenberg","year":"2004","unstructured":"Rottenberg\n              S\n            , von TscharnerC, RoosjePJ. Thymoma-associated exfoliative dermatitis in cats. Vet Pathol2004;41(4):429\u201333."},{"issue":"10","key":"bib30","series-title":"J Small Anim Pract","first-page":"451","article-title":"Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection","volume":"38","author":"Forster-Van Hijfte","year":"1997","unstructured":"Forster-Van Hijfte\n              MA\n            , CurtisCF, WhiteRN. Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. 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